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21.
Pravenec M Churchill PC Churchill MC Viklicky O Kazdova L Aitman TJ Petretto E Hubner N Wallace CA Zimdahl H Zidek V Landa V Dunbar J Bidani A Griffin K Qi N Maxova M Kren V Mlejnek P Wang J Kurtz TW 《Nature genetics》2008,40(8):952-954
To identify renally expressed genes that influence risk for hypertension, we integrated expression quantitative trait locus (QTL) analysis of the kidney with genome-wide correlation analysis of renal expression profiles and blood pressure in recombinant inbred strains derived from the spontaneously hypertensive rat (SHR). This strategy, together with renal transplantation studies in SHR progenitor, transgenic and congenic strains, identified deficient renal expression of Cd36 encoding fatty acid translocase as a genetically determined risk factor for spontaneous hypertension. 相似文献
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T cells with receptors for IgD 总被引:3,自引:0,他引:3
The role of IgD in the immune response has been elusive, although its predominance on the cell surface suggests a receptor function. We have shown previously that euthymic but not athymic BALB/c mice, injected with IgD before antigen, exhibit enhanced antibody responses which can be transferred by T cells. Isotype-specific T cells have been reported to have both upward and downward immunoregulatory effects. Here we demonstrate the existence of T cells with receptors for IgD, and show that exposure to IgD in vivo or in vitro significantly increases the number of T delta cells in the spleen and lymph nodes but not in the thymus. The kinetics of T delta-cell appearance in vivo parallels that of the immunoenhancing effect which occurs after injection of IgD. These T delta cells are of the Lyt 1+2- T-cell phenotype. 相似文献
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In 1914, the physics discipline had reached a very similar stage of development in Australia and Japan. A generation later the paths of development had considerably diverged. A systematic comparison of the evolution of physics in the two countries during these years identifies factors—political, economic and cultural—that led to this divergence, but it also uncovers a number of underlying parallels. 相似文献
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好氧颗粒污泥是一种全新概念的污水生物处理技术。介绍了好氧颗粒污泥技术的理论基础,包括好氧污泥形成机理及理化特性研究,探讨了影响好氧颗粒污泥形成的因素以及工业应用的方向和前景。 相似文献
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Saether BE Lande R Engen S Weimerskirch H Lillegård M Altwegg R Becker PH Bregnballe T Brommer JE McCleery RH Merilä J Nyholm E Rendell W Robertson RR Tryjanowski P Visser ME 《Nature》2005,436(7047):99-102
Theoretical studies have shown that variation in density regulation strongly influences population dynamics, yet our understanding of factors influencing the strength of density dependence in natural populations still is limited. Consequently, few general hypotheses have been advanced to explain the large differences between species in the magnitude of population fluctuations. One reason for this is that the detection of density regulation in population time series is complicated by time lags induced by the life history of species that make it difficult to separate the relative contributions of intrinsic and extrinsic factors to the population dynamics. Here we use population time series for 23 bird species to estimate parameters of a stochastic density-dependent age-structured model. We show that both the strength of total density dependence in the life history and the magnitude of environmental stochasticity, including transient fluctuations in age structure, increase with generation time. These results indicate that the relationships between demographic and life-history traits in birds translate into distinct population dynamical patterns that are apparent only on a scale of generations. 相似文献
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Naloxone-induced inhibition of ethanol dependence in mice 总被引:3,自引:0,他引:3
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A. B. Ślebodziński A. L. C. Wallace 《Cellular and molecular life sciences : CMLS》1977,33(8):1108-1110
Summary The injection of thyrotropin releasing hormone into cattle resulted in a rapid decrease in the T4/T3 molar ratio. 2 breeds of cattle, Shorthorn and Africander Cross were studied. The decrease in the T4/T3 molar ratio was significantly greater in the Shorthorn breed. It is concluded that acute stimulation of the thyroid gland with TRH results in enhanced release of both T3 and T4 and that T3 is discharged more rapidly than T4. 相似文献