Chromosomal effects of adeno-associated virus vector integration.

Adeno-associated virus (AAV) vectors are currently being used in several clinical gene-therapy trials (see the NIH OBA Human Gene Transfer Clinical Trials Database); however, little is known about the chromosomal effects of vector integration. Here we report that integrated vector proviruses are associated with chromosomal deletions and other rearrangements and are frequently located on chromosome 19 (although not at the wildtype AAV integration site).     

A Study on the Design for Object-Oriented Adaptive Decision-Making Teams

1 .ＩＮＴＲＯＤＵＣＴＩＯＮＩｎＣ3Ｉｓｙｓｔｅｍｓ,ｒｅｃｅｉｖｉｎｇ ,ｔｒａｎｓｍｉｓｓｉｏｎ ,ｐｒｏｃｅｓｓｉｎｇａｎｄｄｉｓｐｌａｙｏｆｉｎｆｏｒｍａｔｉｏｎａｒｅｄｅｖｅｌｏｐｅｄｃｏｎｃｅｒｎｉｎｇｔｈｅｄｅ ｃｉｓｉｏｎｍａｋｉｎｇｏｆｃｏｍｍａｎｄｅｒｓ.Ｔｈｅｒｅｆｏｒｅ,ｔｈｅｍａｊｏｒｔａｓｋｏｆａＣ3Ｉｓｙｓｔｅｍｉｓｆｏｃｕｓｅｄｏｎｄｅｃｉｓｉｏｎｍａｋｉｎｇ.Ｗｉｔｈｔｈｅｒａｐｉｄｄｅｖｅｌｏｐｍｅｎｔｏｆｃｏｍｍｕｎｉｃａｔｉｏｎａｎｄｎｅｔｗｏｒｋ ,ｔｅａｍｄｅｃｉｓ…     

大学英语教学低起点高目标的反思及应对策略

本文结合目前大学英语教学现状及社会对外语人才的要求，尝试着探讨大学英语教学低起点的缘由和高目标要求的应对策略。其意在为大学外语教学建立特殊的机制，充分发挥教育资源的整合效益，起到优化教学过程，达到最优化教学效果，最终最大限度地满足社会对各类外语人才的需要。     

Decision trees for forecasting

Recent years have seen an increasing cross-fertilization between the fields of decision analysis and forecasting. Decision-analytic models often require forecasts as inputs, and aspects of the Bayesian decision-theoretic framework underlying decision analysis have proved useful to forecasting, particularly in contexts where subjective judgemental inputs are required. This paper describes the use of decision tree analysis for forecasting and illustrates its use for corporate divisional forecasting and planning. A specialized decision-analytic technique, acts as events, is also described and illustrated to forecast a new product's earnings. Conclusions are drawn about the applicability of decision analysis for forecasting.     

Indoxyl derivatives of drug metabolites

Summary Indoxyl derivatives were detected as minor products among the urinary metabolites of two trial drugs, a benzodiazepine (GP 55 129) and a benzophenone (CGP 11 952). Their structures were elucidated by NMR and mass spectroscopy. Presumably, metabolites containing potential aldehyde functions react spontaneously with endogenous indoxyl. Such derivatives have not hitherto been encountered in drug metabolism.     

MeV Pb离子在非晶Si中的射程离散──离子束混合和增强扩散的影响

１．０ＭｅＶ２０８Ｐｂ离子在非晶Ｓｉ中的投影射程ＲＰ和射程偏差ΔＲＰ作为注量和温度二者的函数用背散射法进行测定．注量的变化范围为５×１０１３～７×１０１４ｃｍ－２．注入是在室温和ｔ＝－１２０℃下完成的．由由实验所确定的投影射程，射程偏差与注量或温度无关，并且分别等于２９５和７２．２ｎｍ．与ＴＲＩＭ８６的计算结果相比较，发现ＲＰ的偏离为１８％，而ΔＲＰ的偏离为３６％．ＲＰ和ΔＲＰ二者与注量及温度的无关性，排除了所观察到的与ＴＲＩＭ的矛盾是由于注入期间辐射增强扩散或离子束混合效应而引起的解释。     

海湾战争的特点和启示

本文阐述海湾战争的特点和启示,着重分析了现代空袭模式和防空面临的问题。     

Aspirin-like drugs may block pain independently of prostaglandin synthesis inhibition

Summary Using flurbiprofen, a chiral anti-inflammatory and analgesic 2-arylpropionic acid derivative, the enantiomers of which are not converted to each other (less than 5%) in rats or man, we obtained evidence that prostaglandin synthesis inhibition is primarily mediating the anti-inflammatory activity but prostaglandin synthesis independent mechanisms contribute to the analgesic effects. Thus, the S-form inhibited prostaglandin synthesis, inflammation and nociception in rats. The R-form had much less effect on prostaglandin synthesis and did not affect inflammation. It did, however, block nociception in rats almost as potently as the S-form. S-flurbiprofen, in contrast to the R-form, was clearly ulcerogenic in the gastrointestinal mucosa. These results indicate additional molecular mechanisms of analgesia and suggest the use of R-arylpropionic acids as analgesics.     

钢丝绳动参数的新检测方法研究

本文研究了一种新的非接触式的钢丝绳运动速度，运行距离及所受张力的检测方法；分析了检测系统各组成部分的工作原理和检测信号的处理过程。提出了在实测过程中应注意的问题和应进一步开展的研究工作