Interaction of cocaine and bunaphtide on the3H-norepinephrine uptake mechanism on isolated left atrium of guinea-pig

Summary Bunaphtide induces a blockade in the³H-norepinephrine uptake and retention in the isolated guinea-pig left atrium. However, this blockade does not seems to be related with the cardiodepressant effect of the drug.     

Cadmium-113 FT NMR-spectra of rabbit liver metallothioneins

Summary Cadmium-113 FT NMR-spectra of rabbit liver metallothionein-I and-II gave 6 and 7 NMR-signals, respectively, at between 610 and 670 ppm downfield from aqueous Cd(ClO₄)₂ solution (0.1 M).We thank Mr M. Imanari (JEOL) for the NMR-data and Dr K. Kubota (NIES) for encouragement.     

Effect of water oxygenation on oxygen consumption and gill ventilation of the crab, Carcinus maenas (L.)]

At 15 degrees C, the oxygen uptake rate of Carcinus maenas was practically independent of the ambient oxygen pressure betueen 50 and 500 Torr. Within this range, hyperventilatory and hypoventilatory responses were observed in hypoxic and hyperoxic conditions respectively whereas the oxygen extraction coefficient remained more or less constant.     

Modification of the action of pentagastrin on acid secretion by botulinum toxin

Summary I.v. botulinum toxin after 60–90 min abolished the dose-response relationship between pentagastrin and gastric acid secretion in anesthetized rats and guinea-pigs. The toxin reduced but did not abolish the acid stimulatory effect of histamine. As expected, the acid response to vagal stimulation was abolished and that to methacholine in rats was unaltered by the toxin.Acknowledgment. We are grateful to the generosity of Dr Edward J. Schantz, Food Research Institute, University of Wisconsin, for the botulinum toxin used. — This research was supported by NIH grant 1 RO1 AM 17125, The Secretion of Pepsin.