Photon emission of phagocytes in relation to stress and disease.

Phagocytes, the first-line cells of the body's defence mechanisms against invading pathogens, kill microorganisms by means of lysosomal degradative enzymes and highly toxic reactive oxygen intermediates. The reactive oxygen compounds are produced, in a process called the 'respiratory burst', by the NADPH oxidase complex in plasma membranes, and by myeloperoxidase in phagolysosomes after degranulation. These processes generate electronically excited states which, on relaxation, emit photons, giving rise to phagocyte chemiluminescence (CL). This paper describes the conditions for the measurement of CL, and reviews the activity of phagocytes from individuals undergoing stress or disease. The capability of phagocytes to emit photons reflects remarkably well the pathophysiological state of the host. In many cases even the magnitude of the stress, the presence of a pathogen in the body, or the activity of the disease can be estimated. Physiological changes, e.g. in the reproductive cycle, can also be predicted.     

电磁感应探测的灵敏度研究

本文讨论了电磁感应探测传感线圈的匝数与探测灵敏度的关系,论证了在探距确定的条件下,探测传感线圈直径的最优值。     

多元有序地质数据的最优分割法在工程中的应用

采用数学地质理论中的多元有序地质数据的最优分割方法对工程场地松散岩土层亚层进行了划分。实践证明 ,在土样物理力学性能评价指标选取合理的前提下 ,该方法简单方便 ,行之有效 ,可作为一种辅助手段帮助地质人员开展对土层的详细研究     

在田径技术动作教学中如何观察分析错误

每个动作技能的形成，必然要经历一个不断改正错误、逐步完善定型的过程，最后才能达到熟练掌握、运用自如的程度。而准确及时地发现错误则是改正错误、提高动作质量的前提。笔者在归纳错误类型的基础上，提出观察和分析错误的方法。     

寡头垄断市场下的广告竞争策略研究

在寡头垄断市场条件下 ,给出了广告竞争下进行同时决策及两阶段决策时的广告策略模型 ,得出了厂商利润最大化时的广告策略 ,通过对结果的分析 ,说明了在不同情况下广告策略的选择 ,并在此基础上 ,分析了利润最大化时的市场份额的确定。     

Mechanical Design and Research on Process of Air Suction Drawing System of Spunbonded Nonwoven

The design guideline for the air suction drawing system with auxiliary air was analyzed, a spunbonding nonwoven system named PADHL1 - 3200 was designed and polypropylene （PP） spunbonded nonwoven fabrics with excellent properties were achieved after many trial runs. On the other hand, the suction air velocity （VA） was calculated and the influence of VA on the bonding strengh of PP nonwoven fabrics was Studied as well. It was found that VA is 1.5 - 2.5 times of the spinning velocity. With the increase of VA, PP fibers become finer and the bonding strength of PP nonwoven fabrics increases as well.     

A propos d'antibiotiques insolubles

Summary The authors show the antibiotic activity of water-insoluble salts of hydrosoluble antibiotics in the case of penicillin G (salts of iron, copper, silver, gold, and uranium) and streptomycin (oleate).     

Long term monitoring of urban subsidence by Permanent Scatterer DInSAR

When using differential SAR interferometry (DInSAR) to monitor the surface deformation over a long time scale, it is often strongly affected by the spatial and temporal decorrelations and atmospheric dishomogeneities. The recently developed Permanent Scatterers (PS) technique proposed by Fertti et al. can overcome these difficulties by interpreting time-series of interferometric phase only at coherent point scatterers. In this study, we apply this PS technique using 25 ERS-1/2 scenes from 1992 to 2000 to monitor the subsidence in Suzhou. By using the linear deformation model, the deformation map in Suzhou urban area over the eight years is obtained. And the calculated results are in good agreement with the measurements of leveling.     

A recurrent mutation in MED12 leading to R961W causes Opitz-Kaveggia syndrome

Opitz-Kaveggia syndrome (also known as FG syndrome) is an X-linked disorder characterized by mental retardation, relative macrocephaly, hypotonia and constipation. We report here that the original family for whom the condition is named and five other families have a recurrent mutation (2881C>T, leading to R961W) in MED12 (also called TRAP230 or HOPA), a gene located at Xq13 that functions as a thyroid receptor-associated protein in the Mediator complex.     

Genetic studies of diseases

Genomic alterations lead to cancer complexity and form a major hurdle for comprehensive understanding of the molecular mechanisms underlying oncogenesis. In this review, we describe recent advances in studying cancer-associated genes from a systems biology point of view. The integration of known cancer genes onto protein and signaling networks reveals the characteristics of cancer genes within networks. This approach shows that cancer genes often function as network hub proteins which are involved in many cellular processes and form focal nodes in information exchange between many signaling pathways. Literature mining allows constructing gene-gene networks, in which new cancer genes can be identified. The gene expression profiles of cancer cells are used for reconstructing gene regulatory networks. By doing so, genes which are involved in the regulation of cancer progression can be picked up from these networks, after which their functions can be further confirmed in the laboratory.