基于ADV ISOR的混联式混合动力电动车仿真分析

节能环保是当今世界的两大主题,仿真分析可以在制作实车前节约大量的实验成本;建立了在正常的工况下几种不同类型混合动力电动汽车的发动机、蓄电池组和电动机的仿真模型;并对几种不同类型电动汽车的控制策略进行分析,根据仿真结果,选择混联式混合动力电动车进行优化设计;结果表明,混联式电动车达到了低油耗、低排放和节能的目标。     

Paraneoplastic myasthenic syndrome IgG inhibits 45Ca2+ flux in a human small cell carcinoma line

Certain cancers exert unexplained remote effects on the nervous system. Small cell carcinoma (SCC) of the lung, a tumour capable of spike electrogenesis and which is of possible neural crest origin, is present in approximately 70% of patients with the Lambert-Eaton myasthenic syndrome (LEMS), a disorder characterized by fatigable muscle weakness. Patients with this syndrome have a defect in the (Ca2+-dependent) quantal release of acetylcholine from motor nerve terminals evoked by a nerve impulse or by high K+ (ref.5), and a decreased number of presynaptic active zone particles. The physiological and morphological features of the syndrome can be transferred to mice by the patients' IgG, consistent with an autoantibody interfering with the function of voltage-dependent Ca2+ channels. Here we demonstrate that K+-induced 45Ca2+ flux in a cultured human SCC line is significantly reduced by LEMS IgG, suggesting that in SCC-LEMS an autoantibody to tumour Ca2+-channel determinants is triggered; its cross-reaction with similar determinants at the motor nerve terminal could lead to the remote neurological syndrome.     

The synthesis and in vivo assembly of functional antibodies in yeast

The yeast Saccharomyces cerevisiae can synthesize, process and secrete higher eukaryotic proteins. We have investigated the expression of immunoglobulin chains in yeast and demonstrate here the synthesis, processing and secretion of light and heavy chains, the glycosylation of heavy chain, the intracellular localization of these foreign proteins by immunofluorescence, and the detection of functional antibodies in cells co-expressing both chains. This may provide the basis of a microbial fermentation process for the production of monoclonal antibodies. The co-expression of light and heavy chains in Escherichia coli has been reported but functional antibodies were not assembled in vivo. Furthermore, only low-level assembly of these chains was found in vitro.     

Yψ（t）—复合非时齐Poisson过程模型结构可靠度

讨论强度为Ｙψ（ｔ），其中Ｙ为初始随机变量，ψ（ｔ）是ｔ的单调递减连续实函数，应力为强度函数λ（ｔ）＝ｅｘｐ（α＋βｔ）（ｔ≥０；α，β为任意实数）的复合非时齐Ｐｏｉｓｓｏｎ过程模型结构可靠度，获得应力与强度在各种不同情况下的结构可靠度表达式。     

Lack of effect of neurotransmitters on cyclic AMP phosphodiesterase activity in an insect CNS.

The inhibition of cyclic nucleotide phosphodiesterase from the nerve cord of Manduca sexta was studied using theophylline as a model compound. 11 putative neurotransmitters had no effect on enzyme activity.     

对绩效考评中目标实施的战略性思考

绩效目标是绩效考评必不可少的一个重要组成部分。基于激励理论对企业绩效目标的设置和实施进行了探讨，得到如下几点启示：一是制定有一定难度，但切实可行的目标是提高员工绩效的关键；二是确定员工期望结果、建立反馈机制、将报酬和绩效联系起来、阐明职责和自我管理是实现目标和提高员工绩效的可靠保证。