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101.
Eric J. R. Jansen Nick H. M. van Bakel Anthon J. M. Coenen Sander H. van Dooren Hermina A. M. van Lith Gerard J. M. Martens 《Cellular and molecular life sciences : CMLS》2010,67(4):629-640
The vacuolar (H+)-ATPase (V-ATPase) is the main regulator of intraorganellar pH and in neuroendocrine cells is controlled by its accessory
subunit, Ac45. Here, we report the discovery of the first isoform of a V-ATPase accessory subunit, namely an Ac45-like protein,
denoted Ac45LP. Phylogenetic analysis revealed a lineage-dependent evolutionary history: Ac45 is absent in birds, and Ac45LP
is absent in placental mammals, whereas all other tetrapod species contain both genes. In contrast to Ac45, Ac45LP is not
proteolytically cleaved, a prerequisite for proper Ac45 routing. Intriguingly, Xenopus Ac45LP mRNA was expressed in developing neural tissue and in neural crest cells. In adult Xenopus, Ac45 mRNA is widely expressed mostly in neuroendocrine tissues, while Ac45LP mRNA expression was found to be restricted
to the kidney and the lung. This novel Ac45LP may provide additional possibilities for V-ATPase regulation during neurodevelopment
as well as in kidney and lung cells. 相似文献
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Prüfer K Munch K Hellmann I Akagi K Miller JR Walenz B Koren S Sutton G Kodira C Winer R Knight JR Mullikin JC Meader SJ Ponting CP Lunter G Higashino S Hobolth A Dutheil J Karakoç E Alkan C Sajjadian S Catacchio CR Ventura M Marques-Bonet T Eichler EE André C Atencia R Mugisha L Junhold J Patterson N Siebauer M Good JM Fischer A Ptak SE Lachmann M Symer DE Mailund T Schierup MH Andrés AM Kelso J Pääbo S 《Nature》2012,486(7404):527-531
Two African apes are the closest living relatives of humans: the chimpanzee (Pan troglodytes) and the bonobo (Pan paniscus). Although they are similar in many respects, bonobos and chimpanzees differ strikingly in key social and sexual behaviours, and for some of these traits they show more similarity with humans than with each other. Here we report the sequencing and assembly of the bonobo genome to study its evolutionary relationship with the chimpanzee and human genomes. We find that more than three per cent of the human genome is more closely related to either the bonobo or the chimpanzee genome than these are to each other. These regions allow various aspects of the ancestry of the two ape species to be reconstructed. In addition, many of the regions that overlap genes may eventually help us understand the genetic basis of phenotypes that humans share with one of the two apes to the exclusion of the other. 相似文献
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The El Ni?o/Southern Oscillation (ENSO) phenomenon is believed to have operated continuously over the last glacial-interglacial cycle. ENSO variability has been suggested to be linked to millennial-scale oscillations in North Atlantic climate during that time, but the proposals disagree on whether increased frequency of El Ni?o events, the warm phase of ENSO, was linked to North Atlantic warm or cold periods. Here we present a high-resolution record of surface moisture, based on the degree of peat humification and the ratio of sedges to grass, from northern Queensland, Australia, covering the past 45,000 yr. We observe millennial-scale dry periods, indicating periods of frequent El Ni?o events (summer precipitation declines in El Ni?o years in northeastern Australia). We find that these dry periods are correlated to the Dansgaard-Oeschger events--millennial-scale warm events in the North Atlantic climate record--although no direct atmospheric connection from the North Atlantic to our site can be invoked. Additionally, we find climatic cycles at a semiprecessional timescale (approximately 11,900 yr). We suggest that climate variations in the tropical Pacific Ocean on millennial as well as orbital timescales, which determined precipitation in northeastern Australia, also exerted an influence on North Atlantic climate through atmospheric and oceanic teleconnections. 相似文献
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Determinants of woody cover in African savannas 总被引:8,自引:0,他引:8
Sankaran M Hanan NP Scholes RJ Ratnam J Augustine DJ Cade BS Gignoux J Higgins SI Le Roux X Ludwig F Ardo J Banyikwa F Bronn A Bucini G Caylor KK Coughenour MB Diouf A Ekaya W Feral CJ February EC Frost PG Hiernaux P Hrabar H Metzger KL Prins HH Ringrose S Sea W Tews J Worden J Zambatis N 《Nature》2005,438(7069):846-849
Savannas are globally important ecosystems of great significance to human economies. In these biomes, which are characterized by the co-dominance of trees and grasses, woody cover is a chief determinant of ecosystem properties. The availability of resources (water, nutrients) and disturbance regimes (fire, herbivory) are thought to be important in regulating woody cover, but perceptions differ on which of these are the primary drivers of savanna structure. Here we show, using data from 854 sites across Africa, that maximum woody cover in savannas receiving a mean annual precipitation (MAP) of less than approximately 650 mm is constrained by, and increases linearly with, MAP. These arid and semi-arid savannas may be considered 'stable' systems in which water constrains woody cover and permits grasses to coexist, while fire, herbivory and soil properties interact to reduce woody cover below the MAP-controlled upper bound. Above a MAP of approximately 650 mm, savannas are 'unstable' systems in which MAP is sufficient for woody canopy closure, and disturbances (fire, herbivory) are required for the coexistence of trees and grass. These results provide insights into the nature of African savannas and suggest that future changes in precipitation may considerably affect their distribution and dynamics. 相似文献
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