Common variants at 12q15 and 12q24 are associated with infant head circumference

To identify genetic variants associated with head circumference in infancy, we performed a meta-analysis of seven genome-wide association studies (GWAS) (N = 10,768 individuals of European ancestry enrolled in pregnancy and/or birth cohorts) and followed up three lead signals in six replication studies (combined N = 19,089). rs7980687 on chromosome 12q24 (P = 8.1 × 10(-9)) and rs1042725 on chromosome 12q15 (P = 2.8 × 10(-10)) were robustly associated with head circumference in infancy. Although these loci have previously been associated with adult height, their effects on infant head circumference were largely independent of height (P = 3.8 × 10(-7) for rs7980687 and P = 1.3 × 10(-7) for rs1042725 after adjustment for infant height). A third signal, rs11655470 on chromosome 17q21, showed suggestive evidence of association with head circumference (P = 3.9 × 10(-6)). SNPs correlated to the 17q21 signal have shown genome-wide association with adult intracranial volume, Parkinson's disease and other neurodegenerative diseases, indicating that a common genetic variant in this region might link early brain growth with neurological disease in later life.     

An overview of marine & utility system for offshore platform

Main marine & utility (M & U) systems are essential to the routine operation of offshore units,and are extremely important as they are the system that will ensure the basic safety of offshore platforms. This paper gave a general explanation and guideline of the marine & utility systems in offshore projects including their interface with topside,M & U engineering,equipment sizing operation and control.     

Weyl’s ‘agens theory’ of matter and the Zurich Fichte

This paper investigates Hermann Weyl’s reception of philosophical concepts stemming from the German Idealist Johann Gottlieb Fichte. In particular, Weyl’s ‘agens theory’ of matter, which he held around 1925, will be looked at. In the extant literature, the—admittedly also important—influence of Husserl on Weyl has mainly been addressed. Thus, apart from investigating some detailed Fichtean inheritances in Weyl’s concepts of causality, chance and continuity, the general difference which Weyl saw between the philosophies of Fichte and Husserl will also be discussed. For Weyl this is above all a difference between an active constructivism and a rather passive phenomenological seeing (Schau). Further, the paper shows in some detail the way Weyl was drawn into a certain reading of Fichte by his Zurich colleague, the philosopher Fritz Medicus. The methodological frame of the paper is that of Konstellationsforschung, a historical and systematic approach which proves to be particularly fruitful when investigating a (broadly speaking) German Idealist context and which allows special attention to be given to the acting subjects within the constellation under investigation. Conversely, Weyl’s agens theory suggests amendments to this methodology.     

基于Agent软件合成的分布决策支持系统研究

通过Agent技术进行软件合成的分布式决策支持系统研究是AI领域研究热点，尤其是在互联网广泛应用的前提下更具研究价值。本文在分布式决策支持系统DDSS研究成果的基础上，提出了基于Agent软件合成的协同交互AODDSS的构建，包括智能Agent结构，模型和知识的描述，基于Internet/Intranet的AODDSS框架和知识语言KL，Agent间协同交互和复杂问题求解的分布解决方法及流程，以及在商业连锁企业决策中的应用。     

CD4 and CD8 T lymphocyte interplay in controlling tumor growth

The outstanding clinical success of immune checkpoint blockade has revived the interest in underlying mechanisms of the immune system that are capable of eliminating tumors even in advanced stages. In this scenario, CD4 and CD8 T cell responses are part of the cancer immune cycle and both populations significantly influence the clinical outcome. In general, the immune system has evolved several mechanisms to protect the host against cancer. Each of them has to be undermined or evaded during cancer development to enable tumor outgrowth. In this review, we give an overview of T lymphocyte-driven control of tumor growth and discuss the involved tumor-suppressive mechanisms of the immune system, such as senescence surveillance, cancer immunosurveillance, and cancer immunoediting with respect to recent clinical developments of immunotherapies. The main focus is on the currently existing knowledge about the CD4 and CD8 T lymphocyte interplay that mediates the control of tumor growth.