全文获取类型
收费全文 | 68篇 |
免费 | 24篇 |
国内免费 | 7篇 |
专业分类
系统科学 | 10篇 |
现状及发展 | 15篇 |
研究方法 | 6篇 |
综合类 | 67篇 |
自然研究 | 1篇 |
出版年
2022年 | 1篇 |
2021年 | 1篇 |
2020年 | 3篇 |
2019年 | 2篇 |
2018年 | 7篇 |
2017年 | 10篇 |
2016年 | 6篇 |
2015年 | 7篇 |
2014年 | 12篇 |
2013年 | 6篇 |
2012年 | 5篇 |
2011年 | 6篇 |
2010年 | 4篇 |
2009年 | 5篇 |
2008年 | 6篇 |
2007年 | 7篇 |
2006年 | 2篇 |
2005年 | 1篇 |
2004年 | 2篇 |
2003年 | 2篇 |
2002年 | 1篇 |
1999年 | 1篇 |
1971年 | 1篇 |
1967年 | 1篇 |
排序方式: 共有99条查询结果,搜索用时 62 毫秒
51.
Andreas Houben Ali Mohammad Banaei-Moghaddam Sonja Klemme Jeremy N. Timmis 《Cellular and molecular life sciences : CMLS》2014,71(3):467-478
B chromosomes (Bs) are dispensable components of the genome exhibiting non-Mendelian inheritance and have been widely reported on over several thousand eukaryotes, but still remain an evolutionary mystery ever since their first discovery over a century ago [1]. Recent advances in genome analysis have significantly improved our knowledge on the origin and composition of Bs in the last few years. In contrast to the prevalent view that Bs do not harbor genes, recent analysis revealed that Bs of sequenced species are rich in gene-derived sequences. We summarize the latest findings on supernumerary chromosomes with a special focus on the origin, DNA composition, and the non-Mendelian accumulation mechanism of Bs. 相似文献
52.
Rami I. Aqeilan Muhannad Abu-Remaileh Mohammad Abu-Odeh 《Cellular and molecular life sciences : CMLS》2014,71(23):4589-4599
The fragile WWOX gene, encompassing the chromosomal fragile site FRA16D, is frequently altered in human cancers. While vulnerable to DNA damage itself, recent evidence has shown that the WWOX protein is essential for proper DNA damage response (DDR). Furthermore, the gene product, WWOX, has been associated with multiple protein networks, highlighting its critical functions in normal cell homeostasis. Targeted deletion of Wwox in murine models suggests its in vivo requirement for proper growth, metabolism, and survival. Recent molecular and biochemical analyses of WWOX functions highlighted its role in modulating aerobic glycolysis and genomic stability. Cumulatively, we propose that the gene product of FRA16D, WWOX, is a functionally essential protein that is required for cell homeostasis and that its deletion has important consequences that contribute to the neoplastic process. This review discusses the essential role of WWOX in tumor suppression and genomic stability and how its alteration contributes to cancer transformation. 相似文献
53.
In this paper, an adaptive observer for robust control of robotic manipulators is proposed.The lumped uncertainty is estimated using Chebyshev polynomials. Usually, the uncertainty upper bound is required in designing observer-controller structures. However, obtaining this bound is a challenging task. To solve this problem, many uncertainty estimation techniques have been proposed in the literature based on neuro-fuzzy systems. As an alternative, in this paper, Chebyshev polynomials have been applied to uncertainty estimation due to their simpler structure and less computational load.Based on strictly-positive-real(SPR) Lyapunov theory, the stability of the closed-loop system can be verified. The Chebyshev coefficients are tuned based on the adaptation rules obtained in the stability analysis. Also, to compensate the truncation error of the Chebyshev polynomials, a continuous robust control term is designed while in previous related works, usually a discontinuous term is used. An SCARA manipulator actuated by permanent magnet DC motors is used for computer simulations.Simulation results reveal the superiority of the designed method. 相似文献
54.
Mohammad Sadegh Shakeri 《矿物冶金与材料学报》2014,21(4):401-407
In the present research, the effect of CeO2 dopant on the fabrication of transparent lithium aluminosilicate titanate (LAST) glass ceramics was investigated. Nanocrystallineβ-quartz solid solution (s.s.) was observed to be the main phase crystallized in this system. Com-parable refractive indices of the glassy matrix andβ-quartz s.s., as well as the incorporation of very fine grains size were determined as the main reasons for retaining the transparency of the glass ceramics. CeO2 was introduced as a suitable optical agent, playing a role as a network modifier in the glass ceramics, because it does not accelerate the growth process and retards the extended growth of crystals. Optical investi-gations indicate that the Fermi energy level, direct and indirect band gaps, and Urbach energy decrease with increasing nanocrystal content in the glassy matrix of specimens, which can be related to the expansion of conduction band, the enhancement of ionic bonds in the crystal lat-tice, and the enhancement of structural arrangement degree, respectively. 相似文献
55.
Kinetic modeling of copper bioleaching from low-grade ore from the Shahrbabak Copper Complex
下载免费PDF全文
![点击此处可从《矿物冶金与材料学报》网站下载免费的PDF全文](/ch/ext_images/free.gif)
Saman Beikzadeh Noei Saeed Sheibani Fereshteh Rashchi Seyed Mohammad Javad Mirazimi 《矿物冶金与材料学报》2017,24(6):611-620
The copper recovery from low-grade copper sulfide ore was investigated using microbial leaching. Several parameters substantially affect the bioleaching of copper; among them, pulp density and nutrient media were selected for investigation. The optimum conditions for copper recovery were a pulp density of 5 g/mL, a mixed-mineral salt medium of Acidithiobacillus thiooxidans (70vol%) and Acidithiobacillus ferrooxidans (30vol%), and 10vol% of inoculum. Under these conditions, the maximum bioleaching capacity of the medium for copper recovery was determined to be approximately 99%. The effect of pulp density on the kinetics of the bioleaching process was surveyed using both da Silva's method and constrained multilinear regression analysis. The kinetics of copper dissolution followed the shrinking core model, and the process was diffusion controlled at a pulp density of 5 g/mL. Nevertheless, at higher pulp densities, the process was controlled by chemical reaction. 相似文献
56.
Saman Eskandarzadeh Kourosh Eshghi Mohammad Modarres Yazdi Mohsen Bahramgiri 《系统科学与系统工程学报(英文版)》2014,23(3):312-328
In this paper, we address a basic production planning problem with price dependent demand and stochastic yield of production. We use price and target quantity as decision variables to lower the risk of low yield. The value of risk control becomes more important especially for products with short life cycle. This is because, the profit implications of low yield might be unbearable in the short run. We apply Conditional Value at Risk (CVaR) to model the, risk. CVaR measure is a coherent risk measure and thereby having nice conceptual and mathematical underpinnings. It is also widely used in practice. We consider the problem under general demand function and general distribution function of yield and find sufficient conditions under which the problem has a unique local maximum. We also both analytically and numerically analyze the impact of parameter change on the optimal solution. Among our results, we analytically show that with increasing risk aversion, the optimal price increases. This relation is opposite to that of in Newsvendor problem where the uncertainty lies in demand side. 相似文献
57.
Poulikakos PI Persaud Y Janakiraman M Kong X Ng C Moriceau G Shi H Atefi M Titz B Gabay MT Salton M Dahlman KB Tadi M Wargo JA Flaherty KT Kelley MC Misteli T Chapman PB Sosman JA Graeber TG Ribas A Lo RS Rosen N Solit DB 《Nature》2011,480(7377):387-390
Activated RAS promotes dimerization of members of the RAF kinase family. ATP-competitive RAF inhibitors activate ERK signalling by transactivating RAF dimers. In melanomas with mutant BRAF(V600E), levels of RAS activation are low and these drugs bind to BRAF(V600E) monomers and inhibit their activity. This tumour-specific inhibition of ERK signalling results in a broad therapeutic index and RAF inhibitors have remarkable clinical activity in patients with melanomas that harbour mutant BRAF(V600E). However, resistance invariably develops. Here, we identify a new resistance mechanism. We find that a subset of cells resistant to vemurafenib (PLX4032, RG7204) express a 61-kDa variant form of BRAF(V600E), p61BRAF(V600E), which lacks exons 4-8, a region that encompasses the RAS-binding domain. p61BRAF(V600E) shows enhanced dimerization in cells with low levels of RAS activation, as compared to full-length BRAF(V600E). In cells in which p61BRAF(V600E) is expressed endogenously or ectopically, ERK signalling is resistant to the RAF inhibitor. Moreover, a mutation that abolishes the dimerization of p61BRAF(V600E) restores its sensitivity to vemurafenib. Finally, we identified BRAF(V600E) splicing variants lacking the RAS-binding domain in the tumours of six of nineteen patients with acquired resistance to vemurafenib. These data support the model that inhibition of ERK signalling by RAF inhibitors is dependent on levels of RAS-GTP too low to support RAF dimerization and identify a novel mechanism of acquired resistance in patients: expression of splicing isoforms of BRAF(V600E) that dimerize in a RAS-independent manner. 相似文献
58.
59.
Roadway design usually involves choices regarding grade selection and earthwork (transportation) that can be solved using linear programming. Previous work considered the road profile as series of interconnected linear segments. In these models, constraints are included in the linear programming formulation to insure continuity of the road, which cause sharp connectivity points at the intersection of the linear segments. This sharp connectivity needs to be smoothed out after l;he linear programming solution is found and the earth in the smoothed portion of the roadway has to be moved to the landfill. In previous research, the smoothing issue is dealt with after an optimal solution is found. This increases the work required by the design engineer and consequently increases the construction cost; furthermore, the optimal solution is violated by this smoothing operation. In this paper, the issue of sharp connectivity points is resolved by representing the road profile by a quadratic function. The continuit 相似文献
60.
This paper studies a production system where products are produced continuously and whose specification limits are specified for screening inspection. In this paper, we consider dual quality characteristics and different costs associated with each quality characteristic that falls below a lower specification limit or above an upper specification limit. Due to these different costs, the expected total profit will greatly depend on the process parameters, especially a process mean. This paper develops a Markovian-based model for determining the optimum process means with the consideration of dual quality characteristics in a single-stage system. The proposed model is then illustrated through a numerical example and sensitivity analysis is performed to validate the model. The results showed that the optimum process mean for both quality characteristics have a significant effect on the performance of the system. Since the literature survey shows that dealing with multi-quality characteristics is extremely limited, the proposed model, coupled with the Markovian approach, provides a unique contribution to this field. 相似文献