Rare Earth Doped Polymer Waveguide Materials and Devices

1 Results Rare earth doped waveguide amplifiers and devices have been demonstrated in silica, crystal and other glass hosts. These rare earth doped optical waveguide devices are based on inorganic materials. Many processing steps are required and can lead to long fabrication time and low yield.Polymer materials offer many distinct properties compared to inorganic materials, such as ease of fabrication, low production costs, simple processing steps, and compatibility with micro-fabrication technologies. ...     

Pyruvate dehydrogenase kinase regulatory mechanisms and inhibition in treating diabetes, heart ischemia, and cancer

The fraction of pyruvate dehydrogenase complex (PDC) in the active form is reduced by the activities of dedicated PD kinase isozymes (PDK1, PDK2, PDK3 and PDK4). Via binding to the inner lipoyl domain (L2) of the dihydrolipoyl acetyltransferase (E2 60mer), PDK rapidly access their E2-bound PD substrate. The E2-enhanced activity of the widely distributed PDK2 is limited by dissociation of ADP from its C-terminal catalytic domain, and this is further slowed by pyruvate binding to the N-terminal regulatory (R) domain. Via the reverse of the PDC reaction, NADH and acetyl-CoA reductively acetylate lipoyl group of L2, which binds to the R domain and stimulates PDK2 activity by speeding up ADP dissociation. Activation of PDC by synthetic PDK inhibitors binding at the pyruvate or lipoyl binding sites decreased damage during heart ischemia and lowered blood glucose in insulin-resistant animals. PDC activation also triggers apoptosis in cancer cells that selectively convert glucose to lactate. Received 25 August 2006; received after revision 20 November 2006; accepted 20 December 2006     

发展战略与企业管理

加入WTO以后,中国企业面临着经济国际化带来的挑战,如何在激烈竞争中占有一席之地,企业需要认真审视发展战略,以四层级战略管理进行战略能力的系统化设计和布局,尽快做大做强。     

A New Way of the Skeletal Metals Synthesis

1 Results Strongly disordered metals with the high chemical and catalytic activity are often called as skeletal metals.Usually for their preparation the metallides of d-metal (which afterwards will be left in the “skeleton“) and chemically active component(s) are firstly synthesized.Then the last one(s) is (are) removed by the leaching with aqueous solutions of alkalis or carbonates.However,this method sometime fails,first of all,for the reactions,which should be realized in non-aqueous conditions.In th...     

Structural Changes of Water Molecules Upon the Reduction of Quinones in The Reaction Center from Rhodobactery Sphaeroides

1 Results The photosynthetic bacterial reaction center (RC) is a membrane protein complex.The RC is composed of three protein subunits and redox components such as bacteriochlorophylls, bacteriopheophytins,and quinones.The RC performs the photochemical electron transfer from the bacteriochlorophyll dimer through a series of electron donor and acceptor molecules to a secondary quinone,QB.QB accepts electrons from a primary quinone,QA,in two sequential electron transfer reactions.The second electron trans...     

Mutations in the gene encoding the basal body protein RPGRIP1L, a nephrocystin-4 interactor, cause Joubert syndrome

Protein-protein interaction analyses have uncovered a ciliary and basal body protein network that, when disrupted, can result in nephronophthisis (NPHP), Leber congenital amaurosis, Senior-L?ken syndrome (SLSN) or Joubert syndrome (JBTS). However, details of the molecular mechanisms underlying these disorders remain poorly understood. RPGRIP1-like protein (RPGRIP1L) is a homolog of RPGRIP1 (RPGR-interacting protein 1), a ciliary protein defective in Leber congenital amaurosis. We show that RPGRIP1L interacts with nephrocystin-4 and that mutations in the gene encoding nephrocystin-4 (NPHP4) that are known to cause SLSN disrupt this interaction. RPGRIP1L is ubiquitously expressed, and its protein product localizes to basal bodies. Therefore, we analyzed RPGRIP1L as a candidate gene for JBTS and identified loss-of-function mutations in three families with typical JBTS, including the characteristic mid-hindbrain malformation. This work identifies RPGRIP1L as a gene responsible for JBTS and establishes a central role for cilia and basal bodies in the pathophysiology of this disorder.     

要加强对复杂适应性系统的研究——对自组织理论的反思

简单回顾了自组织理论的发展历史、内容和采用的方法，重点分析了自组织理论的研究对象和研究范围；指出自组织理论在研究复杂系统上的局限性——只适于研究简单巨系统，它研究的是系统演化的结果而非过程；自组织理论使用微分方程作为数学工具，要求子系统之间的相互作用要满足叠加原理而不考虑涌现的情况。在此基础上，本文提出要加强复杂适应性系统的研究，具体有两方面的工作：首先要加强计算机作为数学工具的应用，扩展对系统状态描述的范围；另外要加强对层次性的研究，重点是对涌现问题的分析。最后提出现在加强复杂系统的研究应从实际的具体系统入手。     

浅析公路路基主要病害的原因及防治措施

文章通过对公路路基主要病害产生原因的详细分析,探讨并提出了一系列相应的防治措施。     

数据挖掘技术在民办高校管理中的应用

分析了数据挖掘技术在民办高校中的应用现状及前景,以期实现提升民办高校管理水平的目的。