Light-dependent phosphorylation of the carboxy tail of mouse melanopsin

Melanopsin-based phototransduction is involved in non-image forming light responses including circadian entrainment, pupil constriction, suppression of pineal melatonin synthesis, and direct photic regulation of sleep in vertebrates. Given that the functions of melanopsin involve the measurement and summation of total environmental luminance, there would appear to be no need for the rapid deactivation typical of other G-protein coupled receptors. In this study, however, we demonstrate that heterologously expressed mouse melanopsin is phosphorylated in a light-dependent manner, and that this phosphorylation is involved in regulating the rate of G-protein activation and the lifetime of melanopsin’s active state. Furthermore, we provide evidence for light-dependent phosphorylation of melanopsin in the mouse retina using an in situ proximity ligation assay. Finally, we demonstrate that melanopsin preferentially interacts with the GRK2/3 family of G-protein coupled receptor kinases through co-immunoprecipitation assays. Based on the complement of G-protein receptor kinases present in the melanopsin-expressing retinal ganglion cells, GRK2 emerges as the best candidate for melanopsin’s cognate GRK.     

我国加快发展信息高速公路的思考

基于我国发展信息高速公路面临的种种问题，提出我国在发展信息高速公路方面政府行为的设想。     

一种新的H—CgCr肤色模型的肤色检测方法

提出一种新的H—CgCr肤色模型进行肤色检测，该模型充分利用色调和色度信息区分肤色像素和非肤色像素．并利用形态学操作去除检测出皮肤区域中毛刺、空洞等噪声．实验结果表明该方法在复杂光照条件下能有效检测出肤色区域．     

Genome-wide recombination in Chlamydia trachomatis

A new study reports comparative genomic analysis of 52 geographically diverse strains of Chlamydia trachomatis. The authors reconstruct a genome-wide phylogeny of the species and report extensive genome-wide recombination across multiple lineages of this intracellular bacterial pathogen.     

Suan Shu Shu A Book on Numbers and Computations

In December and January of 1983–1984, archaeologists excavating the tomb of an ancient Chinese provincial bureaucrat at a Western Han Dynasty site near Zhangjiashan, in Jiangling county, Hubei Province, discovered a number of books on bamboo strips, including inter alia works on legal statutes, military practice, and medicine. Among these was a previously unknown mathematical work on some 200 bamboo strips, the Suan shu shu, or Book of Numbers and Computations. Based upon other works found in the tomb, especially a copy of the Er nian lü ling (Laws and Decrees of the Second Year (of the reign of empress Lü, i.e. Lü Hou)), archaeologists have dated the tomb to ca. 186 BCE (Lü Hou’s regency lasted from 188 to 180 BCE). The Suan shu shu, as the earliest yet discovered work devoted specifically to mathematics from ancient China, has stirred considerable interest among Chinese historians of science. The translation and commentary offered here draw extensively on the works cited in Sect. 3 below. Several appendixes devoted to specific issues related to translating the Suan shu shu, including its title and the problem of determining English equivalents for various commodities that arise in the text, may be found in Appendix II. An erratum to this article can be found at     

Aspects of Quantum Non-Locality II: Superluminal Causation and Relativity

In a preceding paper, I studied the significance of Jarrett's and Shimony's analyses of ‘factorisability’ into ‘parameter independence’ and ‘outcome independence’ for clarifying the nature of non-locality in quantum phenomena. I focused on four types of non-locality; superluminal signalling, action-at-a-distance, non-separability and holism. In this paper, I consider a fifth type of non-locality: superluminal causation according to ‘logically weak’ concepts of causation, where causal dependence requires neither action nor signalling. I conclude by considering the compatibility of non-factorisable theories with relativity theory. In this connection, I pay special attention to the difficulties that superluminal causation raises in relativistic spacetime. My main findings in this paper are: first, parameter-dependent and outcome-dependent theories both involve superluminal causal connections between outcomes and between settings and outcomes. Second, while relativistic deterministic parameter-dependent theories seem impossible on pain of causal paradoxes, relativistic indeterministic parameter-dependent theories are not subjected to the same challenge. Third, current relativistic non-factorisable theories seem to have some rather unattractive characteristics.     

Distinguishing causality principles

We distinguish two sub-types of each of the two causality principles formulated in connection with the Common Cause Principle in Henson (2005) and raise and investigate the problem of logical relations among the resulting four causality principles. Based in part on the analysis of the status of these four principles in algebraic quantum field theory we will argue that the four causal principles are non-equivalent.     

ATM网络中输出过程的自相似特性

建立一个有限缓冲区的单服务器模型，证明了在队长有有限二阶矩的条件下，输出过程具强渐近二阶自相似性质与输出过程具强渐近二阶自相似性质等价。