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排序方式: 共有108条查询结果,搜索用时 15 毫秒
51.
A. Campbell M. K. Martin K. J. Farrington A. Erdelyi R. Johnston P. Sorby H. V. Whitlock I. G. Pearson R. C. Jones J. A. Haigh C. P. DeGoosh 《Cellular and molecular life sciences : CMLS》1967,23(12):992-993
Zusammenfassung 2-Acetoxy-4-chlor-3,5-dijodbenzanilid zeigte eine hohe Wirksamkeit gegen junge und gereifteF. hepatica andH. controtus in Schaften bei einer oralen Dosis von 25 und 40 mg/kg. Die gute Verträglichkeit der Verbindung in Schafen ergab sich aus Feldversuchen in Australien. 相似文献
52.
53.
In these heady days of genomic enterprise, the wet-bench geneticist may wonder what the future holds in store for those who explore biology in the laboratory. We argue that the goal of genomics is to serve geneticists. 相似文献
54.
TACI and BCMA are receptors for a TNF homologue implicated in B-cell autoimmune disease 总被引:120,自引:0,他引:120
Gross JA Johnston J Mudri S Enselman R Dillon SR Madden K Xu W Parrish-Novak J Foster D Lofton-Day C Moore M Littau A Grossman A Haugen H Foley K Blumberg H Harrison K Kindsvogel W Clegg CH 《Nature》2000,404(6781):995-999
B cells are important in the development of autoimmune disorders by mechanisms involving dysregulated polyclonal B-cell activation, production of pathogenic antibodies, and co-stimulation of autoreactive T cells. zTNF4 (BLyS, BAFF, TALL-1, THANK) is a member of the tumour necrosis factor (TNF) ligand family that is a potent co-activator of B cells in vitro and in vivo. Here we identify two receptors for zTNF4 and demonstrate a relationship between zTNF4 and autoimmune disease. Transgenic animals overexpressing zTNF4 in lymphoid cells develop symptoms characteristic of systemic lupus erythaematosus (SLE) and expand a rare population of splenic B-Ia lymphocytes. In addition, circulating zTNF4 is more abundant in NZBWF1 and MRL-lpr/lpr mice during the onset and progression of SLE. We have identified two TNF receptor family members, TACI and BCMA, that bind zTNF4. Treatment of NZBWF1 mice with soluble TACI-Ig fusion protein inhibits the development of proteinuria and prolongs survival of the animals. These findings demonstrate the involvement of zTNF4 and its receptors in the development of SLE and identify TACI-Ig as a promising treatment of autoimmune disease in humans. 相似文献
55.
Bird MK Allison M Asmar SW Atkinson DH Avruch IM Dutta-Roy R Dzierma Y Edenhofer P Folkner WM Gurvits LI Johnston DV Plettemeier D Pogrebenko SV Preston RA Tyler GL 《Nature》2005,438(7069):800-802
One of Titan's most intriguing attributes is its copious but featureless atmosphere. The Voyager 1 fly-by and occultation in 1980 provided the first radial survey of Titan's atmospheric pressure and temperature and evidence for the presence of strong zonal winds. It was realized that the motion of an atmospheric probe could be used to study the winds, which led to the inclusion of the Doppler Wind Experiment on the Huygens probe. Here we report a high resolution vertical profile of Titan's winds, with an estimated accuracy of better than 1 m s(-1). The zonal winds were prograde during most of the atmospheric descent, providing in situ confirmation of superrotation on Titan. A layer with surprisingly slow wind, where the velocity decreased to near zero, was detected at altitudes between 60 and 100 km. Generally weak winds (approximately 1 m s(-1)) were seen in the lowest 5 km of descent. 相似文献
56.
Implications for prediction and hazard assessment from the 2004 Parkfield earthquake 总被引:5,自引:0,他引:5
Bakun WH Aagaard B Dost B Ellsworth WL Hardebeck JL Harris RA Ji C Johnston MJ Langbein J Lienkaemper JJ Michael AJ Murray JR Nadeau RM Reasenberg PA Reichle MS Roeloffs EA Shakal A Simpson RW Waldhauser F 《Nature》2005,437(7061):969-974
Obtaining high-quality measurements close to a large earthquake is not easy: one has to be in the right place at the right time with the right instruments. Such a convergence happened, for the first time, when the 28 September 2004 Parkfield, California, earthquake occurred on the San Andreas fault in the middle of a dense network of instruments designed to record it. The resulting data reveal aspects of the earthquake process never before seen. Here we show what these data, when combined with data from earlier Parkfield earthquakes, tell us about earthquake physics and earthquake prediction. The 2004 Parkfield earthquake, with its lack of obvious precursors, demonstrates that reliable short-term earthquake prediction still is not achievable. To reduce the societal impact of earthquakes now, we should focus on developing the next generation of models that can provide better predictions of the strength and location of damaging ground shaking. 相似文献
57.
A histochemical study has been made of the main cranial muscles which produce ventilation movements of the rainbow trout. It is shown that a greater proportion of red(aerobic) fibres is present in those muscles known to be active during shallow ventilation than those which become active at greater ventilation volumes. An ordered recruitment of red, pink and white fibres within these muscles is also likely. 相似文献
58.
Temperature adaptation in myosin of Antarctic fish. 总被引:1,自引:0,他引:1
59.
GABA, bicuculline and central inhibition 总被引:35,自引:0,他引:35
60.
Bicuculline and central GABA receptors 总被引:3,自引:0,他引:3