Chiral pyrrolidine-azole conjugates: Simple and efficient asymmetric organocatalysts for Michael addition to nitrostyrenes

Simple pyrrolidine-azole conjugates have been synthesized and found to be efficient catalysts for asymmetric Michael addition to nitrostyrenes. The identified optimal catalysts, pyrrolidine-azoles 2, 8 and 13, could catalyze the asymmetric Michael addition of a range of Michael donors and nitrostyrenes in high yields (up to 99%) and excellent stereoselectivities (up to 99:1 dr and 97% ee).     

‘Public’ Science: Hydrogen Balloons and Lavoisier's Decomposition of Water

The balloon mania between 1783 and 1785 put an extraordinary strain on the Paris Academy of Sciences, threatening its status as the highest tribunal of European science. Faced with repeated royal directives and public frenzy, the Academy manoeuvred carefully to steer the research toward the hydrogen balloon and thereby to maintain its scientific superiority. Antoine-Laurent Lavoisier seized this moment when the promise of ‘the empire of airs’ brought science to the centre of public attention to push his theoretical reform for chemistry. He utilized the established protocol of the Academy and the resources of the Republic of Letters to broadly publicize his first decomposition of water in April 1784. Once he attained the publicity and the balloon fever began to cool, he staged a much more elaborate experiment for the experts in February 1785. Although this second, large-scale experiment cost much expense and effort, Lavoisier never published a full account. The differential care given to the two experiments can only be understood in their divergent rhetorical contexts. The written accounts in 1784 addressed the court of public opinion, while the exclusive performance in 1785 aimed at the court of experts to inaugurate the collaborative phase of the Chemical Revolution.     

赏乐杂谈

赏乐如读书，如赏诗、赏画，懂得熟赏、精赏才能体会赏乐之乐。     

正向行为支持与大学生心理健康

正向行为支持是一种在对问题行为进行功能性评估的基础上制定相应策略，以求改善问题行为和提高生活质量的方法。将正向行为支持运用到大学生心理健康教育的实践当中，构建大学生心理健康教育的正向行为支持模式，是提升大学生心理健康教育实效性的有益尝试。     

Mapping CD20 molecules on the lymphoma cell surface using atomic force microscopy

Atomic force microscopy (AFM) was used to locate CD20 molecules on the surface of lymphoma Raji cells. Rituximab (a monoclonal antibody against CD20) molecules were linked onto the AFM tip via a polyethylene glycol (PEG) linker. Raji cells were adsorbed onto glass slides coated with poly-L-lysine. First, the CD20 distribution in a local area of the cell surface was visualized using the AFM lift scan mode. Second, 16 × 16 force curves were obtained from the same cell area to construct the CD20-rituximab binding force map. Finally, free rituximab was added to block the CD20 molecules on the cell surface and the lift phase image and CD20-rituximab force map were obtained again. The experimental results indicated that when the lift height was greater than the length of the PEG linker, no recognition sites were observed in the lift phase image. However, as the lift height decreased to the length of the PEG linker, some recognition sites were observed in the lift phase image and these sites were generally consistent with the pixels in the force map. After blocking, both the recognition sites in the lift phase image and the gray pixels in the binding force map decreased markedly. These results can improve our understanding of the distribution of protein molecules on the cell surface and facilitate further investigations into cellular functions.     

安全宣传教育有效性的探索与实践

文章就根治"三违"问题,在煤矿安全宣传教育的探索上,做出一系列行之有效的安全教育方法,着力转变全矿职工的安全观念,实现矿井的长治久安.     

某砖混结构阳台挑梁加固方法及案例分析

针对某多层砖混结构阳台挑梁混凝土强度偏低,通过几种加固方案的比较采用增加钢拉杆和粘贴碳纤维布的方法进行加固处理,加固后进行荷载试验,试验表明构件满足承载力使用要求,投入使用多年,使用状况良好,表明所采用的加固方案有效,可供类似工程加固设计参考.     

白芨多糖Mark-Houwink方程的建立

自制了系列分子量规格的白芨多糖对照品(BT01～05),采用凝胶渗透色谱示差/多角激光光散射(GPC-RI/MALLS)技术测得其分子量,粘度法测得以水为溶剂、25℃条件下的特性粘数,建立白芨多糖的Mark-Houwink方程为[η]=7×10-4M1.10.     

机器人位姿精度概率等高线及其作法

本文论述机器人在工作空间内的位姿精度概率等高线及其作法,从这些等高线中,可以获得一些定性和定量信息。为搞清楚机器人位姿精度在整个工作空间内的分布情况,确定机器人的合理工作范围提供可行的方法,同时也为改进设计或合理使用机器人提供依据。     

高灰煤在CO_2中的催化气化

在常压流动态 CO_2气氛下,用 PRT—1型热天平考察了平朔气煤、晋城无烟煤和西曲焦煤洗中煤中的矿物组分在气化反应中的自催化作用和添加催化剂的催化作用。试验结果表明,高灰煤均比石墨具有较高的气化活性;不同煤种对气化催化剂均有一定的选择配伍性;对于灰分含量最高的西曲焦煤洗中煤的气化,硫铁矿渣具有比 K_2CO_3更为显著的催化活性,在一定范围内是一种较好的可弃性高灰煤气化催化剂。