大学生抑郁水平、身体自尊水平与体育锻炼参与的调查研究

通过问卷调查和统计分析的方法,对大学生有无体育锻炼参与习惯与抑郁水平、身体自尊水平的关系进行了调查研究,结果表明:(1)总体上来看,大学生的抑郁水平和身体自尊水平具有性别差异。男大学生具有较高的身体自尊水平,较低的抑郁水平;(2)大学生抑郁水平与身体自尊水平具有高度负相关,身体自尊水平可能是体育锻炼影响大学生抑郁水平的心理中介变量;(3)有锻炼习惯的男女大学生比没有锻炼习惯的大学生具有较低的抑郁水平和较高的身体自尊水平,其中女生比男生的差异更为显著。     

应用光纤光栅传感器监测高性能混凝土的早期变形特性

高性能混凝土（HPC）早期形变和变化规律的研究有助于指导高层建筑、大跨梁结构等的设计与施工。使用埋设型FBG应变传感器成功检测了HPC早期的变形特性,特别是混凝土硬化前后（浇注后24h内）的变形情况。结果表明,硬化前后高性能混凝土的变形,特别是浇注初期24h内变形增加很快,表现为温度膨胀变形和自收缩变形,影响其中长期性能。HPC构件配筋与否对温度变形没有影响,但由于受配筋骨架约束,自收缩相对无筋构件减小,总变形增大。不同尺寸构件的数据分析表明,HPC早期变形受构件尺寸影响很小。     

Bojungbangdocktang inhibits vascular endothelial growth factor induced angiogenesis via blocking the VEGF/VEGFR2 signaling pathway in human umbilical vein endothelial cells

Oriental herbal medicines have been widely used for the prevention or treatment of various diseases including cancer in Asia. However, to prove their chemo preventive efficacies in modern times, scientific evidence for those herbal medicines is required. Thus, in the present study, an effective herbal cocktail Bojungbangdocktang (BJBDT) was investigated to elucidate antiangiogenic mechanism in vitro and in vivo. BJBDT significantly inhibited vascular endothelial growth factor (VEGF) induced proliferation in HUVECs at nontoxic concentrations, despite weak cytotoxicity against human umbilical vein endothelial cells (HUVECs). BJBDT also significantly suppressed VEGF-induced migration and tube formation of HUVECs. Furthermore, BJBDT treatment resulted in pale color and low hemoglobin level in Matrigel plugs, as well as dark red color and high hemoglobin level in untreated control. Interestingly, BJBDT specifically inhibited the binding of VEGF to vascular endothelial growth factor receptor 2 (VEGFR2), but not VEGFR1. In addition, friedelin, formononetin, ginsenoside Rb1, naringin, atractyloside, diosgenin, and allantonin were identified from BJBDT by high-performance liquid chromatography (HPLC) analysis as a quality of control. Taken together, these results suggest that BJBDT is a potent angiogenesis inhibitor blocking the VEGF/VEGFR2 signaling pathway in HUVECs. Supported by the Korea Science and Engineering Foundation Grant from the Korean Government (Ministry of Science and Technology) (Grant No. R13-2007-019-00000-0)     

高层建筑中非结构构件的抗震性能试验分析

当前针对主体结构抗震性能的研究很多,但针对非结构构件抗震性能研究较少。为此,对高层建筑中非结构构件的抗震性能进行试验分析。利用统一建筑规范对非结构构件抗震计算进行规定,通过FEMA273、FEMA356依次对非结构构件性能与设计方法进行规定。选用楼面反应谱法对非结构构件抗震性能进行分析。将加速度看作调整核心,完成对加速度时程曲线振幅的调整,将其看作试验加速度波。地震波选用EL Centro-NS、Taft-NS与天津-NS地震波。通过ANSYS软件建立模型,获取不同楼层楼面反应谱,通过时程分析,采用ANSYS软件对吊顶抗震性能以及有无设置45°悬吊线吊顶抗震性能进行分析。通过非结构构件模拟器进行浮放设备抗震性能试验分析。依据试验得出以下结论：楼层越高,吊顶和浮放设备越容易在地震作用下被损坏;设置45°悬吊线能够有效提高抗震性能。     

川南地区阳新统气藏异常高压形成转化和预测、

本文基于自然流体压裂成藏机理和岩体力学,紧密结合川南阳新统气截基本特征,探讨异常高压形成和转化机理,进而建立定量预测气层异常高压物理一数学镬型.经矿场实际资并验证,气层压力预测值绝对误差一般小于2.0MPa,相对误差一般小于5.0%.     

Mitochondrial permeability transition in cardiac ischemia–reperfusion: whether cyclophilin D is a viable target for cardioprotection?

Growing number of studies provide strong evidence that the mitochondrial permeability transition pore (PTP), a non-selective channel in the inner mitochondrial membrane, is involved in the pathogenesis of cardiac ischemia–reperfusion and can be targeted to attenuate reperfusion-induced damage to the myocardium. The molecular identity of the PTP remains unknown and cyclophilin D is the only protein commonly accepted as a major regulator of the PTP opening. Therefore, cyclophilin D is an attractive target for pharmacological or genetic therapies to reduce ischemia–reperfusion injury in various animal models and humans. Most animal studies demonstrated cardioprotective effects of PTP inhibition; however, a recent large clinical trial conducted by international groups demonstrated that cyclosporine A, a cyclophilin D inhibitor, failed to protect the heart in patients with myocardial infarction. These studies, among others, raise the question of whether cyclophilin D, which plays an important physiological role in the regulation of cell metabolism and mitochondrial bioenergetics, is a viable target for cardioprotection. This review discusses previous studies to provide comprehensive information on the physiological role of cyclophilin D as well as PTP opening in the cell that can be taken into consideration for the development of new PTP inhibitors.     

Giant magneto-elastic coupling in multiferroic hexagonal manganites

The motion of atoms in a solid always responds to cooling or heating in a way that is consistent with the symmetry of the given space group of the solid to which they belong. When the atoms move, the electronic structure of the solid changes, leading to different physical properties. Therefore, the determination of where atoms are and what atoms do is a cornerstone of modern solid-state physics. However, experimental observations of atomic displacements measured as a function of temperature are very rare, because those displacements are, in almost all cases, exceedingly small. Here we show, using a combination of diffraction techniques, that the hexagonal manganites RMnO3 (where R is a rare-earth element) undergo an isostructural transition with exceptionally large atomic displacements: two orders of magnitude larger than those seen in any other magnetic material, resulting in an unusually strong magneto-elastic coupling. We follow the exact atomic displacements of all the atoms in the unit cell as a function of temperature and find consistency with theoretical predictions based on group theories. We argue that this gigantic magneto-elastic coupling in RMnO3 holds the key to the recently observed magneto-electric phenomenon in this intriguing class of materials.     

Loss of the autophagy protein Atg16L1 enhances endotoxin-induced IL-1beta production

Systems for protein degradation are essential for tight control of the inflammatory immune response. Autophagy, a bulk degradation system that delivers cytoplasmic constituents into autolysosomes, controls degradation of long-lived proteins, insoluble protein aggregates and invading microbes, and is suggested to be involved in the regulation of inflammation. However, the mechanism underlying the regulation of inflammatory response by autophagy is poorly understood. Here we show that Atg16L1 (autophagy-related 16-like 1), which is implicated in Crohn's disease, regulates endotoxin-induced inflammasome activation in mice. Atg16L1-deficiency disrupts the recruitment of the Atg12-Atg5 conjugate to the isolation membrane, resulting in a loss of microtubule-associated protein 1 light chain 3 (LC3) conjugation to phosphatidylethanolamine. Consequently, both autophagosome formation and degradation of long-lived proteins are severely impaired in Atg16L1-deficient cells. Following stimulation with lipopolysaccharide, a ligand for Toll-like receptor 4 (refs 8, 9), Atg16L1-deficient macrophages produce high amounts of the inflammatory cytokines IL-1beta and IL-18. In lipopolysaccharide-stimulated macrophages, Atg16L1-deficiency causes Toll/IL-1 receptor domain-containing adaptor inducing IFN-beta (TRIF)-dependent activation of caspase-1, leading to increased production of IL-1beta. Mice lacking Atg16L1 in haematopoietic cells are highly susceptible to dextran sulphate sodium-induced acute colitis, which is alleviated by injection of anti-IL-1beta and IL-18 antibodies, indicating the importance of Atg16L1 in the suppression of intestinal inflammation. These results demonstrate that Atg16L1 is an essential component of the autophagic machinery responsible for control of the endotoxin-induced inflammatory immune response.     

环形加热法熔体温度场的实验和理论研究

在直径为０．２ｍｍ铂丝构成的圆环形坩埚内，通过电流加热，在环圈内形成厚度为０．２ｍｍ的圆形ＫＮｂＯ３溶液，实验测量了熔液内温度场和流体速度场。该文应用一维重力对流和扩散模型，对温度场的分布进行了理论分析。