Single artificial-atom lasing

Solid-state superconducting circuits are versatile systems in which quantum states can be engineered and controlled. Recent progress in this area has opened up exciting possibilities for exploring fundamental physics as well as applications in quantum information technology; in a series of experiments it was shown that such circuits can be exploited to generate quantum optical phenomena, by designing superconducting elements as artificial atoms that are coupled coherently to the photon field of a resonator. Here we demonstrate a lasing effect with a single artificial atom--a Josephson-junction charge qubit--embedded in a superconducting resonator. We make use of one of the properties of solid-state artificial atoms, namely that they are strongly and controllably coupled to the resonator modes. The device is essentially different from existing lasers and masers; one and the same artificial atom excited by current injection produces many photons.     

结合RFID Smart Phone和EPC网络的智能移动采购系统

近年来由于无线射频对象辨识技术(RFID)的快速发展,使低成本、可大量部署的与可涵盖大面积的无线射频对象识别器有突破性的进展.由读取器(Reader)、感应器(Transponder)与中介系统(Middleware System)3者串联而成的无线射频对象辨识架构,将形成未来生产线自动化、物料管理与物流业的新兴架构.由国际组织EPCglobal Inc.所倡导的EPC Network是RFID应用的标准科技,目前世界各大零售通路商如Wal-Mart、Tesco及Metro、P＆G、Gillette等皆积极参与电子商品条形码EPC(Electronic Product Code)的应用.本论文针对RFID技术的EPC网络架构,实作一套综合RFID智能手机、EPC网络的智能移动采购系统.使用者以具有RFID Reader的智能手机进行采购,Content Web Server与ODS Server负责记录EPC Code的商品数据,透过EPC网络的Object Tracing功能将商品直接运送到使用者家中;或由家中的RFID冰箱主动通知使用者所需采购信息,传送至智能手机进行采购,完成电子交易.     

Heterogeneous pathways and timing of factor departure during translation initiation

The initiation of translation establishes the reading frame for protein synthesis and is a key point of regulation. Initiation involves factor-driven assembly at a start codon of a messenger RNA of an elongation-competent 70S ribosomal particle (in bacteria) from separated 30S and 50S subunits and initiator transfer RNA. Here we establish in Escherichia coli, using direct single-molecule tracking, the timing of initiator tRNA, initiation factor 2 (IF2; encoded by infB) and 50S subunit joining during initiation. Our results show multiple pathways to initiation, with orders of arrival of tRNA and IF2 dependent on factor concentration and composition. IF2 accelerates 50S subunit joining and stabilizes the assembled 70S complex. Transition to elongation is gated by the departure of IF2 after GTP hydrolysis, allowing efficient arrival of elongator tRNAs to the second codon presented in the aminoacyl-tRNA binding site (A site). These experiments highlight the power of single-molecule approaches to delineate mechanisms in complex multicomponent systems.     

Autistic-like behaviour and cerebellar dysfunction in Purkinje cell Tsc1 mutant mice

Autism spectrum disorders (ASDs) are highly prevalent neurodevelopmental disorders, but the underlying pathogenesis remains poorly understood. Recent studies have implicated the cerebellum in these disorders, with post-mortem studies in ASD patients showing cerebellar Purkinje cell (PC) loss, and isolated cerebellar injury has been associated with a higher incidence of ASDs. However, the extent of cerebellar contribution to the pathogenesis of ASDs remains unclear. Tuberous sclerosis complex (TSC) is a genetic disorder with high rates of comorbid ASDs that result from mutation of either TSC1 or TSC2, whose protein products dimerize and negatively regulate mammalian target of rapamycin (mTOR) signalling. TSC is an intriguing model to investigate the cerebellar contribution to the underlying pathogenesis of ASDs, as recent studies in TSC patients demonstrate cerebellar pathology and correlate cerebellar pathology with increased ASD symptomatology. Functional imaging also shows that TSC patients with ASDs display hypermetabolism in deep cerebellar structures, compared to TSC patients without ASDs. However, the roles of Tsc1 and the sequelae of Tsc1 dysfunction in the cerebellum have not been investigated so far. Here we show that both heterozygous and homozygous loss of Tsc1 in mouse cerebellar PCs results in autistic-like behaviours, including abnormal social interaction, repetitive behaviour and vocalizations, in addition to decreased PC excitability. Treatment of mutant mice with the mTOR inhibitor, rapamycin, prevented the pathological and behavioural deficits. These findings demonstrate new roles for Tsc1 in PC function and define a molecular basis for a cerebellar contribution to cognitive disorders such as autism.     

Bridging the Systematic Thinking Gap Between East and West: An Insight into the Yin-Yang-Based System Theory

Paralleling with the contribution of Western systems thinking to the development of modern Chinese system theory, the authors notice that the concept of yin-yang is scattered in many social science researches in the West. However, those researches were still not rich enough to yield insights into the core value of yin-yang and, in turn, there is seemly no one unified guiding law or principle which governs both its theoretical and empirical applications. In this study, axiom system of the Yin-Yang-based system has been proposed and elaborated through the comparisons of systematic thinking between East and West. After incorporating the concept of causal chains, it can also be used to work as quantitative tool for business decision analysis in management practices. The aim of this study is to bridge the contemporary systematic thinking gap between East and West and to provide a complement to aid in further development of system theory.     

Effects of brain monoamine depletion on thermoregulation, active avoidance, and food and water intake in rats

Intraventricular administration of 6-OHDA or 5,6-DHT suppressed food intake, whereas their effect on active avoidance produced a suppression with the former and an enhancement with the latter. The increased water intake was specifically associated with 5,6-DHT treatment in rats.     

Action Research to Enrich Learning from Conflict to Collaboration: Bridging the First-Year Students and the NGOs Agencies in Service Learning Program

Systemic Practice and Action Research - The purpose of this study was to diagnosing and solving problem through the process of conflict resolution and getting the NGOs agencies involved in a...     

Ablation of LMO4 in glutamatergic neurons impairs leptin control of fat metabolism

The LIM domain only 4 (LMO4) protein is expressed in the hypothalamus, but its function there is not known. Using mice with LMO4 ablated in postnatal glutamatergic neurons, including most neurons of the paraventricular (PVN) and ventromedial (VMH) hypothalamic nuclei where LMO4 is expressed, we asked whether LMO4 is required for metabolic homeostasis. LMO4 mutant mice exhibited early onset adiposity. These mice had reduced energy expenditure and impaired thermogenesis together with reduced sympathetic outflow to adipose tissues. The peptide hormone leptin, produced from adipocytes, activates Jak/Stat3 signaling at the hypothalamus to control food intake, energy expenditure, and fat metabolism. Intracerebroventricular infusion of leptin suppressed feeding similarly in LMO4 mutant and control mice. However, leptin-induced fat loss was impaired and activation of Stat3 in the VMH was blunted in these mice. Thus, our study identifies LMO4 as a novel modulator of leptin function in selective hypothalamic nuclei to regulate fat metabolism.     

Slip zone and energetics of a large earthquake from the Taiwan Chelungpu-fault Drilling Project

Determining the seismic fracture energy during an earthquake and understanding the associated creation and development of a fault zone requires a combination of both seismological and geological field data. The actual thickness of the zone that slips during the rupture of a large earthquake is not known and is a key seismological parameter in understanding energy dissipation, rupture processes and seismic efficiency. The 1999 magnitude-7.7 earthquake in Chi-Chi, Taiwan, produced large slip (8 to 10 metres) at or near the surface, which is accessible to borehole drilling and provides a rare opportunity to sample a fault that had large slip in a recent earthquake. Here we present the retrieved cores from the Taiwan Chelungpu-fault Drilling Project and identify the main slip zone associated with the Chi-Chi earthquake. The surface fracture energy estimated from grain sizes in the gouge zone of the fault sample was directly compared to the seismic fracture energy determined from near-field seismic data. From the comparison, the contribution of gouge surface energy to the earthquake breakdown work is quantified to be 6 per cent.