Authorware制作课件解疑及操作技巧

介绍了Authorware软件使用过程中的一些常见问题并给出了具体的解决方案 ;说明了在Au thorware软件使用过程中如何利用一些操作技巧     

多层住宅生活消防共用给水系统的几点思考

文中就多层住宅生活、消防共用系统的技术经济问题进行了讨论。提出了采用紧急关闭水阀和合理选用变频泵等技术措施。为共用系统的功能发挥和运行可靠提供了保障。     

太阳能空调的可行性研究

对太阳能空调系统进行了定性分析 ,从环保、节能角度阐述了发展太阳能空调的优势所在。提出了太阳能空调将具有广阔的市场前景。     

Population-based resequencing of ANGPTL4 uncovers variations that reduce triglycerides and increase HDL

Resequencing genes provides the opportunity to assess the full spectrum of variants that influence complex traits. Here we report the first application of resequencing to a large population (n = 3,551) to examine the role of the adipokine ANGPTL4 in lipid metabolism. Nonsynonymous variants in ANGPTL4 were more prevalent in individuals with triglyceride levels in the lowest quartile than in individuals with levels in the highest quartile (P = 0.016). One variant (E40K), present in approximately 3% of European Americans, was associated with significantly lower plasma levels of triglyceride and higher levels of high-density lipoprotein cholesterol in European Americans from the Atherosclerosis Risk in Communities Study and in Danes from the Copenhagen City Heart Study. The ratio of nonsynonymous to synonymous variants was higher in European Americans than in African Americans (4:1 versus 1.3:1), suggesting population-specific relaxation of purifying selection. Thus, resequencing of ANGPTL4 in a multiethnic population allowed analysis of the phenotypic effects of both rare and common variants while taking advantage of genetic variation arising from ethnic differences in population history.     

Alcohol dehydrogenase 2 is a major hepatic enzyme for human retinol metabolism

The metabolism of all-trans- and 9-cis-retinol/ retinaldehyde has been investigated with focus on the activities of human, mouse and rat alcohol dehydrogenase 2 (ADH2), an intriguing enzyme with apparently different functions in human and rodents. Kinetic constants were determined with an HPLC method and a structural approach was implemented by in silico substrate dockings. For human ADH2, the determined K_m values ranged from 0.05 to 0.3 μM and k_cat values from 2.3 to 17.6 min⁻¹, while the catalytic efficiency for 9-cis-retinol showed the highest value for any substrate. In contrast, poor activities were detected for the rodent enzymes. A mouse ADH2 mutant (ADH2Pro47His) was studied that resembles the human ADH2 setup. This mutation increased the retinoid activity up to 100-fold. The K_m values of human ADH2 are the lowest among all known human retinol dehydrogenases, which clearly support a role in hepatic retinol oxidation at physiological concentrations. Received 12 October 2006; received after revision 6 December 2006; accepted 8 January 2007     

ON THE COLLISION DETECTION PROBLEM OF TWO MOVING OBJECTS DESCRIBED BY ALGEBRAIC SETS

In this paper, the collision problem of two moving objects is investigated. The objects are described by two algebraic sets （ellipses or circles in the paper）. The collision problem discussed involves both static and dynamic case. The static case is that each object moves with known velocity. We use nonlinear programming to decide whether the objects collide. The dynamic case is that each object is controlled by a constraint external force which can be regulated online. For the dynamic case, the collision problem can be modelled as a Minmax problem which can be solved by using differential games. If collision occurs, the time and place of the first collision are given. The moving trajectories are provided in the paper.     

Sul meccanismo di azione della streptomicina

Summary A study was undertaken on the variations of the redox potential level produced by streptomycinin vitro andin vivo. We have been able to show that, owing to an oxidative effect, streptomycin produces an increase of the redox potential level. This oxidative effect varies in degree according to the condition of the patient.We also found that in the blood and in the spinal fluid of patients suffering from tubercular meningitis factors are present which inhibit the action of streptomycin.The results of our findings lead to the conclusion that the dose of streptomycin must be varied according to the condition of the patient if the constant level required for an efficient therapy is to be maintained in the blood and in the spinal fluid.