排序方式: 共有47条查询结果,搜索用时 15 毫秒
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Malek RL Wang HY Kwitek AE Greene AS Bhagabati N Borchardt G Cahill L Currier T Frank B Fu X Hasinoff M Howe E Letwin N Luu TV Saeed A Sajadi H Salzberg SL Sultana R Thiagarajan M Tsai J Veratti K White J Quackenbush J Jacob HJ Lee NH 《Nature genetics》2006,38(2):234-239
Cardiovascular disorders are influenced by genetic and environmental factors. The TIGR rodent expression web-based resource (TREX) contains over 2,200 microarray hybridizations, involving over 800 animals from 18 different rat strains. These strains comprise genetically diverse parental animals and a panel of chromosomal substitution strains derived by introgressing individual chromosomes from normotensive Brown Norway (BN/NHsdMcwi) rats into the background of Dahl salt sensitive (SS/JrHsdMcwi) rats. The profiles document gene-expression changes in both genders, four tissues (heart, lung, liver, kidney) and two environmental conditions (normoxia, hypoxia). This translates into almost 400 high-quality direct comparisons (not including replicates) and over 100,000 pairwise comparisons. As each individual chromosomal substitution strain represents on average less than a 5% change from the parental genome, consomic strains provide a useful mechanism to dissect complex traits and identify causative genes. We performed a variety of data-mining manipulations on the profiles and used complementary physiological data from the PhysGen resource to demonstrate how TREX can be used by the cardiovascular community for hypothesis generation. 相似文献
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Huffman PR Brome CR Butterworth JS Coakley KJ Dewey MS Dzhosyuk SN Golub R Greene GL Habicht K Lamoreaux SK Mattoni CE McKinsey DN Wietfeldt FE Doyle JM 《Nature》2000,403(6765):62-64
Accurate measurement of the lifetime of the neutron (which is unstable to beta decay) is important for understanding the weak nuclear force and the creation of matter during the Big Bang. Previous measurements of the neutron lifetime have mainly been limited by certain systematic errors; however, these could in principle be avoided by performing measurements on neutrons stored in a magnetic trap. Neutral-particle and charged-particle traps are widely used for studying both composite and elementary particles, because they allow long interaction times and isolation of particles from perturbing environments. Here we report the magnetic trapping of neutrons. The trapping region is filled with superfluid 4He, which is used to load neutrons into the trap and as a scintillator to detect their decay. Neutrons in the trap have a lifetime of 750(+330)(-200) seconds, mainly limited by their beta decay rather than trap losses. Our experiment verifies theoretical predictions regarding the loading process and magnetic trapping of neutrons. Further refinement of this method should lead to improved precision in the neutron lifetime measurement. 相似文献
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Zusammenfassung Die Fähigkeit zur Anreicherung von rotem Chlorphenol wird durch Stickoxydul, Methoxyfluran und Thiopental bei isolierten Fischharnkanälchen herabgesctzt, während Halothan ohne Wirkung blieb. Es wird gefolgert, dass allgemeine Betäubungsmittel den Transport organischer Säuren in benachbarten Nierenkanälchen beeinflussen.
This work was supported by the Harold C. Strong Anesthesia Research Fund. 相似文献
This work was supported by the Harold C. Strong Anesthesia Research Fund. 相似文献
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Wechsler J Greene M McDevitt MA Anastasi J Karp JE Le Beau MM Crispino JD 《Nature genetics》2002,32(1):148-152