Common sequence variants on 20q11.22 confer melanoma susceptibility

We conducted a genome-wide association pooling study for cutaneous melanoma and performed validation in samples totaling 2,019 cases and 2,105 controls. Using pooling, we identified a new melanoma risk locus on chromosome 20 (rs910873 and rs1885120), with replication in two further samples (combined P < 1 x 10(-15)). The per allele odds ratio was 1.75 (1.53, 2.01), with evidence for stronger association in early-onset cases.     

Aristotle, US Public Diplomacy, and the Cold War: The Work of Carnes Lord

Carnes Lord is an eminent Aristotelian scholar who has since the mid-1970s intermittently occupied positions within the United States government. This article considers the linkages between his writings on Aristotle and the standpoints he has adopted when in government, with particular reference to the period in the early 1980s when he fulfilled an important role in developing a public diplomacy and information strategy against the Soviet Union. Attention is given to Lord’s interpretation and application, in both his writings and his policy-making, of several key aspects of Aristotle’s political thought, such as rhetoric, regimes, and education. The influence of Leo Strauss on Lord’s thinking is also taken into account.