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Moore RB Oborník M Janouskovec J Chrudimský T Vancová M Green DH Wright SW Davies NW Bolch CJ Heimann K Slapeta J Hoegh-Guldberg O Logsdon JM Carter DA 《Nature》2008,451(7181):959-963
Many parasitic Apicomplexa, such as Plasmodium falciparum, contain an unpigmented chloroplast remnant termed the apicoplast, which is a target for malaria treatment. However, no close relative of apicomplexans with a functional photosynthetic plastid has yet been described. Here we describe a newly cultured organism that has ultrastructural features typical for alveolates, is phylogenetically related to apicomplexans, and contains a photosynthetic plastid. The plastid is surrounded by four membranes, is pigmented by chlorophyll a, and uses the codon UGA to encode tryptophan in the psbA gene. This genetic feature has been found only in coccidian apicoplasts and various mitochondria. The UGA-Trp codon and phylogenies of plastid and nuclear ribosomal RNA genes indicate that the organism is the closest known photosynthetic relative to apicomplexan parasites and that its plastid shares an origin with the apicoplasts. The discovery of this organism provides a powerful model with which to study the evolution of parasitism in Apicomplexa. 相似文献
223.
High frequency of BRAF mutations in nevi 总被引:23,自引:0,他引:23
Pollock PM Harper UL Hansen KS Yudt LM Stark M Robbins CM Moses TY Hostetter G Wagner U Kakareka J Salem G Pohida T Heenan P Duray P Kallioniemi O Hayward NK Trent JM Meltzer PS 《Nature genetics》2003,33(1):19-20
To evaluate the timing of mutations in BRAF (v-raf murine sarcoma viral oncogene homolog B1) during melanocytic neoplasia, we carried out mutation analysis on microdissected melanoma and nevi samples. We observed mutations resulting in the V599E amino-acid substitution in 41 of 60 (68%) melanoma metastases, 4 of 5 (80%) primary melanomas and, unexpectedly, in 63 of 77 (82%) nevi. These data suggest that mutational activation of the RAS/RAF/MAPK pathway in nevi is a critical step in the initiation of melanocytic neoplasia but alone is insufficient for melanoma tumorigenesis. 相似文献
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The ant Temnothorax albipennis uses a technique known as tandem running to lead another ant from the nest to food--with signals between the two ants controlling both the speed and course of the run. Here we analyse the results of this communication and show that tandem running is an example of teaching, to our knowledge the first in a non-human animal, that involves bidirectional feedback between teacher and pupil. This behaviour indicates that it could be the value of information, rather than the constraint of brain size, that has influenced the evolution of teaching. 相似文献
227.
Schawinski K Khochfar S Kaviraj S Yi SK Boselli A Barlow T Conrow T Forster K Friedman PG Martin DC Morrissey P Neff S Schiminovich D Seibert M Small T Wyder TK Bianchi L Donas J Heckman T Lee YW Madore B Milliard B Rich RM Szalay A 《Nature》2006,442(7105):888-891
Detailed high-resolution observations of the innermost regions of nearby galaxies have revealed the presence of supermassive black holes. These black holes may interact with their host galaxies by means of 'feedback' in the form of energy and material jets; this feedback affects the evolution of the host and gives rise to observed relations between the black hole and the host. Here we report observations of the ultraviolet emissions of massive early-type galaxies. We derive an empirical relation for a critical black-hole mass (as a function of velocity dispersion) above which the outflows from these black holes suppress star formation in their hosts by heating and expelling all available cold gas. Supermassive black holes are negligible in mass compared to their hosts but nevertheless seem to play a critical role in the star formation history of galaxies. 相似文献
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Cooperation among workers and their seeming altruism result from strict policing by nestmates. 相似文献