Population-based resequencing of ANGPTL4 uncovers variations that reduce triglycerides and increase HDL

Resequencing genes provides the opportunity to assess the full spectrum of variants that influence complex traits. Here we report the first application of resequencing to a large population (n = 3,551) to examine the role of the adipokine ANGPTL4 in lipid metabolism. Nonsynonymous variants in ANGPTL4 were more prevalent in individuals with triglyceride levels in the lowest quartile than in individuals with levels in the highest quartile (P = 0.016). One variant (E40K), present in approximately 3% of European Americans, was associated with significantly lower plasma levels of triglyceride and higher levels of high-density lipoprotein cholesterol in European Americans from the Atherosclerosis Risk in Communities Study and in Danes from the Copenhagen City Heart Study. The ratio of nonsynonymous to synonymous variants was higher in European Americans than in African Americans (4:1 versus 1.3:1), suggesting population-specific relaxation of purifying selection. Thus, resequencing of ANGPTL4 in a multiethnic population allowed analysis of the phenotypic effects of both rare and common variants while taking advantage of genetic variation arising from ethnic differences in population history.     

纤维混凝土构件在温缩荷载作用下的非线性随机有限元分析

为研究纤维对混凝土构件的抗温缩能力,利用Moelands-Reinhardt(M-R)软化本构关系,采用非线性随机有限元法,即Monte-Carlo法分别对素混凝土和纤维混凝土构件的温降收缩过程进行分析.分析结果表明:纤维的存在可提高混凝土抗拉极限状态温降值,掺加超细纤维对混凝土的增强效果不明显;超细纤维依靠其韧性提高了混凝土的抗拉极限温降值和构件薄弱区域的抗拉能力,减小了由材料性质不均而造成脆断的可能性,在整体上延缓了构件到达抗拉极限状态的过程.     

一种改进的基于效用理论的TOPSIS决策方法

提出了一种改进的TOPSIS决策方法.该方法更多地融合了决策者的主观意愿:用决策者对属性的效用评价代替方案的原始属性数据;用模糊数替代精确值反映决策者对效用值的理解模糊不确定性;同时关注决策者对最佳决策方案属性效用的综合性、均衡性考虑.最后,通过对一个具体决策实例的分析,验证了方法的合理性和有效性.     

Static extracting method of software intended behavior based on API functions invoking

The method of extracting and describing the intended behavior of software precisely has become one of the key points in the fields of software behavior＇s dynamic and trusted authentication. In this paper, the author proposes a specified measure of extracting SIBDS （software intended behaviors describing sets） statically from the binary executable using the software＇s API functions invoking, and also introduces the definition of the structure used to store the SIBDS in detail. Experimental results demonstrate that the extracting method and the storage structure definition offers three strong properties： （i） it can describe the software＇s intended behavior accurately; （ii） it demands a small storage expense; （iii） it provides strong capability to defend against mimicry attack.     

保障公民劳动就业权的里程碑

就业促进法这部法律属于经济法中的宏观经济调控法，把它放到宏观经济调控法的结构中看，仍有一些问题值得探讨和研究。     

与企业全方位深度融合建设精品专业

行业发展是专业建设的前提,与企业结合是专业建设的关键,与生产结合是专业建设的核心,与就业结合是专业建设的根本。航空制造业的快速发展需要大量的数控技术专业人才。数控技术专业的发展离不开与企业的良好合作。企业为专业建设注入活力,专业建设为企业发展提供保障。     

关于C++中继承方式问题的研究

针对C＋＋语言中继承方式及访问权限的理解极易混淆的问题，详细讨论了对C＋＋语言中的继承方式及成员访问权限的教学，并给出具体的继承访问控制的例子。     

加强机关事业单位工会组织规范化

就机关事业单位工会组织的规范化,论述了要以强化民主管理工作为重点的规范化建设,全面提高其工作水平,促进机关事业单位的决策科学化、民主化和民主政治建设,调动干部职工的积极性、创造性,增强机关事业单位凝聚力,推动各项工作圆满完成。     

关于蒲县水土保持工作的探索

文章阐述了蒲县通过多年水土保持工作的治理总结,探索出一些经验,这些经验在实践中产生了强大的能动作用和显著成绩,取得了明显的经济效益、社会效益和生态效益。     

电脑刺绣机针杆及挑线机构设计

以电脑刺绣机原始针杆机构和挑线机构为研究对象,在保持原有针杆运动规律和挑线杆运动规律的前提下,运用机构创新设计理论,分析电脑刺绣机针杆机构和挑线机构的可能选型.为研制新型电脑刺绣机针杆机构和挑线机构奠定了理论基础.