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排序方式: 共有161条查询结果,搜索用时 406 毫秒
1.
研究了一般形式的代数微分方程的全纯解的增长性,并证明了几个有关定理。证明是根据一个关于Wiman-Valiron理论的定理  相似文献   
2.
Ion channels in regulated cell death   总被引:1,自引:1,他引:0  
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3.
Our understanding of the cellular implementation of systems-level neural processes like action, thought and emotion has been limited by the availability of tools to interrogate specific classes of neural cells within intact, living brain tissue. Here we identify and develop an archaeal light-driven chloride pump (NpHR) from Natronomonas pharaonis for temporally precise optical inhibition of neural activity. NpHR allows either knockout of single action potentials, or sustained blockade of spiking. NpHR is compatible with ChR2, the previous optical excitation technology we have described, in that the two opposing probes operate at similar light powers but with well-separated action spectra. NpHR, like ChR2, functions in mammals without exogenous cofactors, and the two probes can be integrated with calcium imaging in mammalian brain tissue for bidirectional optical modulation and readout of neural activity. Likewise, NpHR and ChR2 can be targeted together to Caenorhabditis elegans muscle and cholinergic motor neurons to control locomotion bidirectionally. NpHR and ChR2 form a complete system for multimodal, high-speed, genetically targeted, all-optical interrogation of living neural circuits.  相似文献   
4.
Mendillo M  Laurent S  Wilson J  Baumgardner J  Konrad J  Karl WC 《Nature》2007,448(7151):330-332
On Jupiter's moon Io, volcanic plumes and evaporating lava flows provide hot gases to form an atmosphere that is subsequently ionized. Some of Io's plasma is captured by the planet's strong magnetic field to form a co-rotating torus at Io's distance; the remaining ions and electrons form Io's ionosphere. The torus and ionosphere are also depleted by three time-variable processes that produce a banana-shaped cloud orbiting with Io, a giant nebula extending out to about 500 Jupiter radii, and a jet close to Io. No spatial constraints exist for the sources of the first two; they have been inferred only from modelling the patterns seen in the trace gas sodium observed far from Io. Here we report observations that reveal a spatially confined stream that ejects sodium only from the wake of the Io-torus interaction, together with a visually distinct, spherically symmetrical outflow region arising from atmospheric sputtering. The spatial extent of the ionospheric wake that feeds the stream is more than twice that observed by the Galileo spacecraft and modelled successfully. This implies considerable variability, and therefore the need for additional modelling of volcanically-driven, episodic states of the great jovian nebula.  相似文献   
5.
Murine epidermal stem cells undergo alternate cycles of dormancy and activation, fuelling tissue renewal. However, only a subset of stem cells becomes active during each round of morphogenesis, indicating that stem cells coexist in heterogeneous responsive states. Using a circadian-clock reporter-mouse model, here we show that the dormant hair-follicle stem cell niche contains coexisting populations of cells at opposite phases of the clock, which are differentially predisposed to respond to homeostatic cues. The core clock protein Bmal1 modulates the expression of stem cell regulatory genes in an oscillatory manner, to create populations that are either predisposed, or less prone, to activation. Disrupting this clock equilibrium, through deletion of Bmal1 (also known as Arntl) or Per1/2, resulted in a progressive accumulation or depletion of dormant stem cells, respectively. Stem cell arrhythmia also led to premature epidermal ageing, and a reduction in the development of squamous tumours. Our results indicate that the circadian clock fine-tunes the temporal behaviour of epidermal stem cells, and that its perturbation affects homeostasis and the predisposition to tumorigenesis.  相似文献   
6.
Observational work conducted over the past few decades indicates that all massive galaxies have supermassive black holes at their centres. Although the luminosities and brightness fluctuations of quasars in the early Universe suggest that some were powered by black holes with masses greater than 10 billion solar masses, the remnants of these objects have not been found in the nearby Universe. The giant elliptical galaxy Messier 87 hosts the hitherto most massive known black hole, which has a mass of 6.3 billion solar masses. Here we report that NGC 3842, the brightest galaxy in a cluster at a distance from Earth of 98 megaparsecs, has a central black hole with a mass of 9.7 billion solar masses, and that a black hole of comparable or greater mass is present in NGC 4889, the brightest galaxy in the Coma cluster (at a distance of 103 megaparsecs). These two black holes are significantly more massive than predicted by linearly extrapolating the widely used correlations between black-hole mass and the stellar velocity dispersion or bulge luminosity of the host galaxy. Although these correlations remain useful for predicting black-hole masses in less massive elliptical galaxies, our measurements suggest that different evolutionary processes influence the growth of the largest galaxies and their black holes.  相似文献   
7.
在本文中研究了具有形式:P(f)=W(β_1,β_2…,β_T~′,fα_1,fα_2,…,fα_1)的隆斯基行列式的零点,证明了一个不等式并给出了一些推广,其中f为一超越亚纯函数并且α_i(i=1,2,…,I),β_j(j=1,2,…,I′)为两组线性无关的亚纯函数满足条件: T(r,α_i)=o{T(r,f)},T(r,β_j)=o{T(r,f)}.  相似文献   
8.
9.
信号重构是计算机系统与被控对象进行信息通信的重要环节,在简要分析Shannon重构、ZOH重构和一阶重构等信号重构方法局限性的基础上,提出了一组基于三点插值的重构算法和被控过程采样数据的一步容错预测算法,并将一步容错预测与三点插值算法相结合,建立了对于被控过程信号异常情况有良好容错能力的一步容错预测二阶重构算法。上述的一步容错预测二阶重构算法不仅结构简单、可用于在线控制,而且算法精度和可靠性明显高于普通的ZOH重构和一阶重构算法。  相似文献   
10.
比对分析是工程信号分析与故障诊断的重要手段之一。论文提出并构建了3组可以分别适用于不同情况的数值比对算法,并建立了基于比对残差的渐变型故障分离和突发性故障诊断的实用方法。通过实例说明了比对分析方法在航天外测故障诊断等领域的重要应用。  相似文献   
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