APJ acts as a dual receptor in cardiac hypertrophy

Cardiac hypertrophy is initiated as an adaptive response to sustained overload but progresses pathologically as heart failure ensues. Here we report that genetic loss of APJ, a G-protein-coupled receptor, confers resistance to chronic pressure overload by markedly reducing myocardial hypertrophy and heart failure. In contrast, mice lacking apelin (the endogenous APJ ligand) remain sensitive, suggesting an apelin-independent function of APJ. Freshly isolated APJ-null cardiomyocytes exhibit an attenuated response to stretch, indicating that APJ is a mechanosensor. Activation of APJ by stretch increases cardiomyocyte cell size and induces molecular markers of hypertrophy. Whereas apelin stimulates APJ to activate Gαi and elicits a protective response, stretch signals in an APJ-dependent, G-protein-independent fashion to induce hypertrophy. Stretch-mediated hypertrophy is prevented by knockdown of β-arrestins or by pharmacological doses of apelin acting through Gαi. Taken together, our data indicate that APJ is a bifunctional receptor for both mechanical stretch and the endogenous peptide apelin. By sensing the balance between these stimuli, APJ occupies a pivotal point linking sustained overload to cardiomyocyte hypertrophy.     

Defeasible Reasoning + Partial Models: A Formal Framework for the Methodology of Research Programs

In this paper we show that any reasoning process in which conclusions can be both fallible and corrigible can be formalized in terms of two approaches: (i) syntactically, with the use of defeasible reasoning, according to which reasoning consists in the construction and assessment of arguments for and against a given claim, and (ii) semantically, with the use of partial structures, which allow for the representation of less than conclusive information. We are particularly interested in the formalization of scientific reasoning, along the lines traced by Lakatos’ methodology of scientific research programs. We show how current debates in cosmology could be put into this framework, shedding light on a very controversial topic.     

Is there a functional large intestine in the ferret?

Summary The intestine of the ferret (Putorius furo) is unusual in that there is no external anatomical division between ileum and colon. Up to 8–10 cm from the anus the electrical activity was organized into migrating myoelectric complexes typical of the small intestine. At this point the pattern of electrical activity changed abruptly to that characteristic of the colon, namely short and long spike burst activity. Histological examination showed that at this point the muscular layers were interupted by a band of connective tissue sufficient to permit the functional autonomy of the last part of the intestine.Acknowledgments. The authors are grateful to V. Rayner for helpful discussion and criticism. They acknowledge financial support received from INRA (Department of Veterinary Research).     

Belief Systems and Partial Spaces

One important role of belief systems is to allow us to represent information about a certain domain of inquiry. This paper presents a formal framework to accommodate such information representation. Three cognitive models to represent information are discussed: conceptual spaces (Gärdenfors in Conceptual spaces: the geometry of thought. MIT Press, Cambridge, 2000), state-spaces (van Fraassen in Quantum mechanics: an empiricist view. Clarendon Press, Oxford, 1991), and the problem spaces familiar from artificial intelligence. After indicating their weakness to deal with partial information, it is argued that an alternative, formulated in terms of partial structures (da Costa and French in Science and partial truth. Oxford University Press, New York, 2003), can be provided which not only captures the positive features of these models, but also accommodates the partiality of information ubiquitous in science and mathematics.     

A substantial amount of hidden magnetic energy in the quiet Sun

Deciphering and understanding the small-scale magnetic activity of the quiet solar photosphere should help to solve many of the key problems of solar and stellar physics, such as the magnetic coupling to the outer atmosphere and the coronal heating. At present, we can see only approximately 1 per cent of the complex magnetism of the quiet Sun, which highlights the need to develop a reliable way to investigate the remaining 99 per cent. Here we report three-dimensional radiative transfer modelling of scattering polarization in atomic and molecular lines that indicates the presence of hidden, mixed-polarity fields on subresolution scales. Combining this modelling with recent observational data, we find a ubiquitous tangled magnetic field with an average strength of approximately 130 G, which is much stronger in the intergranular regions of solar surface convection than in the granular regions. So the average magnetic energy density in the quiet solar photosphere is at least two orders of magnitude greater than that derived from simplistic one-dimensional investigations, and sufficient to balance radiative energy losses from the solar chromosphere.