Frederick Pavy (1829-1911) and his opposition to the glycogenic theory of Claude Bernard

For more than 50 years the Guy's Hospital physician Frederick Pavy (1829-1911) attempted to discredit the theory of his erstwhile teacher, Claude Bernard, that liver glycogen was broken down to supply sugar to the systemic circulation. His opposition was driven by his clinical perceptions and was based on two assumptions: the first was that the kidney was a simple filter through which small molecules would diffuse, so that sugar had to be prevented from reaching the systemic circulation. For Pavy, the liver was the barrier. The second was teleological: he could not believe that nature would operate in what he saw as a defective way, i.e. converting sugar into glycogen and then back again. At the beginning of his long working life Pavy regarded himself as a physiologist and was critical of the stagnancy of English physiology which was kept afloat by amateurs like himself in whatever time they could spare from busy private practice. At the end he came to see his own view of carbohydrate metabolism as symbolic of the schism between responsible clinicians (himself) and irresponsible daydreaming physiologists (his opponents).     

今年的“厄尔尼诺”有可能成为世纪之最

近6个月来,太平洋的热带水域一直在扩散,从国际日期变更线蔓延到了南美洲沿海。气象学家对此一直非常关注,密切跟踪着它的变化,因为这就是能够在大气和海洋中翻云覆雨的"厄尔尼诺"现象。而且,有迹象表明,眼下的"厄尔尼诺"现象正在积蓄力量,有可能在未来的几个月内给世界天气带来巨大的变化。热带风暴频频造访墨西哥、智利和秘鲁,使之大雨不断,澳大利亚和印度尼西亚干旱少雨......科学家认为,种种迹象表明,强大的"厄尔尼诺"已经左右了世界天气。本年度的"厄尔尼诺"很可能使本世纪所有的"厄尔尼诺"相形见细。它对热带洋面的影响范…     

Interferon therapy: side effect scare hits French trials

The French Ministry of Health, acting on the advice of its scientific council, has halted clinical trials of interferon in cancer patients after four out of eleven recipients died of myocardial infarctions. Trials are expected to resume after the domestically produced drug stock is repurified and successfully retested. It has been suggested that council oversight should be extended to imported interferon and other experimental drugs which are now being used in human trials without the Ministry's control or knowledge.     

环路热管启动特性的实验研究

通过大量的实验研究了蒸发器内气液分布、反重力工作高度、启动热载荷的大小、热沉温度等因素对启动的影响, 描述并分析了4种不同蒸发器内气液分布情况下的启动现象, 给出了系统温度变化曲线图, 分析了启动的难易程度. 根据实验数据得出结论: (ⅰ) 对于液体干道内充满液体的启动情况, 储液器温度上升的主要原因并不是漏热, 而是回路压力升高所致. (ⅱ) 热载荷大有利于启动. (ⅲ) 未完全绝热时小热载荷下热沉温度不影响启动. (ⅳ) 环路热管在反重力情况下启动时, 当蒸汽槽道存在蒸汽时, 所需启动时间、启动温升增大; 而蒸汽槽道充满液体时, 所需时间、过热度和启动温升都减少. 实验还观察到了反重力启动时呈现两种启动方式的特别现象.     

The fate of injectant coal in blast furnaces: The origin of extractable materials of high molecular mass in blast furnace carryover dusts

The aim of the work was to investigate the fate of injectant coal in blast furnaces and the origin of extractable materials in blast furnace carryover dusts. Two sets of samples including injectant coal and the corresponding carryover dusts from a full sized blast furnace and a pilot scale rig have been examined. The samples were extracted using 1-methyl-2-pyrrolidinone (NMP) solvent and the extracts studied by size exclusion chromatography (SEC). The blast furnace carryover dust extracts contained high molecular weight carbonaceous material, of apparent mass corresponding to 10⁷?10⁸ u, by polystyrene calibration. In contrast, the feed coke and char prepared in a wire mesh reactor under high temperature conditions did not give any extractable material. Meanwhile, controlled combustion experiments in a high-pressure wire mesh reactor suggest that the extent of combustion of injectant coal in the blast furnace tuyeres and raceways is limited by time of exposure and very low oxygen concentration. It is thus likely that the extractable, soot-like material in the blast furnace dust originated in tars is released by the injectant coal. Our results suggest that the unburned tars were thermally altered during the upward path within the furnace, giving rise to the formation of heavy molecular weight (soot-like) materials.