Primary liver carcinogenesis induced by the pesticide 2-(4-tert-butylphenoxy0-1-methylethyl 2-chloroethyl sulphite (Aramite)]

Wistar rats were fed, during 56 weeks, a diet containing 5 g/kg of Aramite. At the end of the treatment, all the surviving animals show, on anatomo-pathological examination, malignant proliferation of the hepatic tissue and, in certain cases, of biliary ducts. This compound, proposed in the past as acaricide in agriculture, can thus be considered as a model substance for induction of malignant liver tumors.     

Satellite heterophagosomes

Summary An incidental observation made during a recent ultrastructural study shows that after ingestion of an erythrocyte by a Kupffer cell surface budding occurred from the heterophagosome leading to the formation of smaller satellite or daughter heterophagosomes. It is suggested that an entire erythrocyte may be too large to digest in a single heterolysosome and that fragmentation into smaller units facilitates digestion by bringing about better contact between the enzymes and substrates.Work supported by grants from the Medical Research Council of Canada.     

Isolation of the optical antipode of mellein from an unidentified fungus

Zusammenfassung Ein Stoffwechselprodukt eines nicht klassifizierten Pilzes wurde als (+)-3-methyl-3,4-dihydro-8-oxyisocumarin, der optischen Antipode von Mellein, identifiziert.     

Bestimmung des α-2-Makroglobulinumsatzes beim Menschen

Summary The turnover of ₂-macroglobulins was measured by quantitative precipitation of the I¹³¹-marked protein, using a specific antiserum. In 6 normal persons, the half-life was found to be between 192 and 267 h. The catabolic rates in relation to the intravascular pool range between 437 and 703 mg/day

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Mit Unterstützung durch die Deutsche Forschungsgemeinschaft.     

On the isolation and cultivation of intracellular symbiotes ofOryzaephilus surinamensis L. (Cucujidae: Coleoptera)

Zusammenfassung Bakterienähnliche Symbionten von Eiern derO. surinamensis sind auf künstlichem Laktose-Nährboden mit Erfolg gezüchtet worden. Die Zuchtformen sehen gleich aus wie die Symbionten der Eier.