电子信息工程专业基础课程体系改革与实践

基于电子信息工程的培养目标,针对目前电子信息工程专业基础课程体系存在的问题,提出了电子信息工程专业基础课程体系改革的内容,通过对专业基础课程体系整合与优化,构建专业基础课程体系平台,目的是为培养＂厚基础、宽口径、能力强、素质高＂电子信息类创新型人才服务。     

基于SIP视频会议多点显示单元的实现

本文提出了SIP视频会议系统多点显示单元的一种实现方法,采用网络监听的方式,通过对Winpcap的调用,实现对网络数据包的捕获,经过SIP协议分析得到需要的视频流数据,对视频流进行解码和多屏显示。此方案有效节省了视频会议系统的带宽和资源问题。     

简论张咏在蜀中的诗歌创作

北宋文人张咏两次入蜀,在蜀中创作了不少的诗歌作品.他用诗歌记录了蜀地的民俗风情,抒写了对友人和家乡的怀念.在蜀中的诗歌创作,既体现了张咏"助治"的文学观,也反映出五代余风和巴蜀地域对其诗风的影响.     

Effect of Mg substitution for La on microstructure, hydrogen storage and electrochemical properties of La1−xMgxNi3.5 (x=0.20, 0.23, 0.25 at%) alloys

The effect of Mg substitution for La on microstructure, hydrogen storage and electrochemical properties of the annealed La_(1-x) Mg_x Ni_3.5(x=0.20, 0.23, 0.25 at%) alloys have been studied. All the samples were mainly composed of(LaMg)_2Ni_7,(LaMg)Ni_3, and LaNi_5 phases. Mg substitution for La changed the phase abundance, but did not change the constitution of all phases, which is con fi rmed by the results of backscattered SEM images and EDS analysis. The P–C isotherms indicated that the La_(1-x) Mg_x Ni_3.5alloys reversibly absorbed and desorbed hydrogen smoothly at 298 K. The hydrogen absorption cyclic stabilities of La_(1-x) Mg_x Ni_3.5alloy after 5 hydrogen absorption/desorption cycles reached the maximum values of91.9% and 96.0% at 298 K and 323 K, respectively. The hydrogen desorption capacity and plateau pressure for the La_(1-x) Mg_x Ni_3.5alloy reached the maximum values of 1.055 H/M and 0.074 MPa, respectively. The desorption capacities of La_(1-x) Mg_x Ni_3.5reached 0.193 H/M and 0.565 H/M in the fi rst minute at 298 K and 323 K, respectively. Electrochemical property measurement indicated that La_(1-x) Mg_x Ni_3.5(x=0.20,0.23, 0.25 at%) alloys possessed excellent activation capability and were completely activated within3 cycles. Discharge capacities of La_(1-x) Mg_x Ni_3.5alloys reached 378.2 m A h/g(x = 0.20 at%), 342.7 m A h/g(x = 0.23 at%), and 369.6 m A h/g(x = 0.25 at%), respectively. Moreover, energy density of La_(1-x) Mg_x Ni_3.5alloy was much larger than that of La_0.80Mg_0.20Ni_3.5 alloy and nearly approaches the maximum value of La0.75Mg0.25Ni3.5. Thus, the La_(1-x) Mg_x Ni_3.5alloy exhibits optimum comprehensive properties of hydrogen storage and electrochemistry.     

热连轧活套系统的分散控制

分析热连轧轧制速度增量对活套系统性能的影响,建立了活套关联系统模型,提高了活套系统模型精度.基于H∞原理,将活套高度与张力系统之间的耦合影响看作扰动,采用分散控制方式,为每台轧机活套系统单独设计控制器.仿真结果表明,基于活套关联系统模型,采用分散方式设计控制器,提高了活套系统的控制性能.     

广西元宝山自然保护区黑熊春季觅食生境特征

在广西元宝山自然保护区野外设置了82个20 m×20 m样方,初步分析黑熊春季觅食地生境特征,对16个生态因子进行主成分分析和单因子适合度检验。结果表明：黑熊觅食地生境特征的主要影响因子为水源距离、海拔和灌木密度;次要因子为食物丰富度因子(树径、乔木密度、乔木距离、灌木距离)、地理性因子(坡向、坡位、坡度)、干扰性因子(树桩密度、树桩距离、倒木距离、人为干扰距离)和微生境因子(避风性、郁闭度)。对黑熊的生境喜好程度分析发现：水源丰富、一定海拔、避风性适中、植物茂盛(乔木密度、灌木密度、乔木距离、灌木距离)、坡向向阳、郁闭度好(30 %～80 %)、坡度较大的山嵴和山坡位为其最适生境。由于人类活动增加,干扰因子(树桩密度、树桩距离、倒木距离、人为干扰距离)成为影响黑熊生境选择的重要因素。     

RNAi screen identifies Brd4 as a therapeutic target in acute myeloid leukaemia

Epigenetic pathways can regulate gene expression by controlling and interpreting chromatin modifications. Cancer cells are characterized by altered epigenetic landscapes, and commonly exploit the chromatin regulatory machinery to enforce oncogenic gene expression programs. Although chromatin alterations are, in principle, reversible and often amenable to drug intervention, the promise of targeting such pathways therapeutically has been limited by an incomplete understanding of cancer-specific dependencies on epigenetic regulators. Here we describe a non-biased approach to probe epigenetic vulnerabilities in acute myeloid leukaemia (AML), an aggressive haematopoietic malignancy that is often associated with aberrant chromatin states. By screening a custom library of small hairpin RNAs (shRNAs) targeting known chromatin regulators in a genetically defined AML mouse model, we identify the protein bromodomain-containing 4 (Brd4) as being critically required for disease maintenance. Suppression of Brd4 using shRNAs or the small-molecule inhibitor JQ1 led to robust antileukaemic effects in vitro and in vivo, accompanied by terminal myeloid differentiation and elimination of leukaemia stem cells. Similar sensitivities were observed in a variety of human AML cell lines and primary patient samples, revealing that JQ1 has broad activity in diverse AML subtypes. The effects of Brd4 suppression are, at least in part, due to its role in sustaining Myc expression to promote aberrant self-renewal, which implicates JQ1 as a pharmacological means to suppress MYC in cancer. Our results establish small-molecule inhibition of Brd4 as a promising therapeutic strategy in AML and, potentially, other cancers, and highlight the utility of RNA interference (RNAi) screening for revealing epigenetic vulnerabilities that can be exploited for direct pharmacological intervention.     

Structural insight into brassinosteroid perception by BRI1

Brassinosteroids are essential phytohormones that have crucial roles in plant growth and development. Perception of brassinosteroids requires an active complex of BRASSINOSTEROID-INSENSITIVE 1 (BRI1) and BRI1-ASSOCIATED KINASE 1 (BAK1). Recognized by the extracellular leucine-rich repeat (LRR) domain of BRI1, brassinosteroids induce a phosphorylation-mediated cascade to regulate gene expression. Here we present the crystal structures of BRI1(LRR) in free and brassinolide-bound forms. BRI1(LRR) exists as a monomer in crystals and solution independent of brassinolide. It comprises a helical solenoid structure that accommodates a separate insertion domain at its concave surface. Sandwiched between them, brassinolide binds to a hydrophobicity-dominating surface groove on BRI1(LRR). Brassinolide recognition by BRI1(LRR) is through an induced-fit mechanism involving stabilization of two interdomain loops that creates a pronounced non-polar surface groove for the hormone binding. Together, our results define the molecular mechanisms by which BRI1 recognizes brassinosteroids and provide insight into brassinosteroid-induced BRI1 activation.