Tumour biology: senescence in premalignant tumours

Oncogene-induced senescence is a cellular response that may be crucial for protection against cancer development, but its investigation has so far been restricted to cultured cells that have been manipulated to overexpress an oncogene. Here we analyse tumours initiated by an endogenous oncogene, ras, and show that senescent cells exist in premalignant tumours but not in malignant ones. Senescence is therefore a defining feature of premalignant tumours that could prove valuable in the diagnosis and prognosis of cancer.     

Activation of old carbon by erosion of coastal and subsea permafrost in Arctic Siberia

The future trajectory of greenhouse gas concentrations depends on interactions between climate and the biogeosphere. Thawing of Arctic permafrost could release significant amounts of carbon into the atmosphere in this century. Ancient Ice Complex deposits outcropping along the ~7,000-kilometre-long coastline of the East Siberian Arctic Shelf (ESAS), and associated shallow subsea permafrost, are two large pools of permafrost carbon, yet their vulnerabilities towards thawing and decomposition are largely unknown. Recent Arctic warming is stronger than has been predicted by several degrees, and is particularly pronounced over the coastal ESAS region. There is thus a pressing need to improve our understanding of the links between permafrost carbon and climate in this relatively inaccessible region. Here we show that extensive release of carbon from these Ice Complex deposits dominates (57?±?2 per cent) the sedimentary carbon budget of the ESAS, the world’s largest continental shelf, overwhelming the marine and topsoil terrestrial components. Inverse modelling of the dual-carbon isotope composition of organic carbon accumulating in ESAS surface sediments, using Monte Carlo simulations to account for uncertainties, suggests that 44?±?10 teragrams of old carbon is activated annually from Ice Complex permafrost, an order of magnitude more than has been suggested by previous studies. We estimate that about two-thirds (66?±?16 per cent) of this old carbon escapes to the atmosphere as carbon dioxide, with the remainder being re-buried in shelf sediments. Thermal collapse and erosion of these carbon-rich Pleistocene coastline and seafloor deposits may accelerate with Arctic amplification of climate warming.     

基于改进KAZE特征的合成孔径雷达匹配算法

自主导航系统是高超声速飞行器自主控制性能的关键因素.合成孔径雷达(SAR)系统作为高超声速飞行器的关键导航设备,其获取的SAR图像受高超飞行器影响存在严重噪声干扰.在分析KAZE特征检测算法的基础上,针对KAZE算法计算复杂度高的问题,引入Fast Explicit Diffusion算法,设计了快速非线性尺度空间构建方法,并在此基础上提出了改进KAZE特征检测算法和基于改进KAZE算法的惯导/SAR组合导航景象匹配算法.通过仿真验证表明,提出的改进KAZE特征算法在保留KAZE算法噪声鲁棒性的同时,有效降低了KAZE算法的复杂度,其计算效率与SIFT算法相当,位置误差估计精度优于SIFT算法.     

微气泡减阻的数值模拟方法及尺寸效应

分别采用混合物模型、欧拉双流体模型和相群平衡模型对底部通气的二维平板微气泡减阻效果进行了模拟分析,探讨了气泡直径、喷气速度对微气泡减阻率的影响,并对其尺度效应进行研究.结果表明:减小气泡直径可以增加微气泡减阻率;在一定的范围内,减阻率随着喷气速度的增加而增大,但喷气速度过小或过大都将影响减阻效果;相群平衡模型比其他2种模型的数值模拟结果更接近于试验结果;由于物体尺寸增加所致的雷诺数增大在一定程度上会降低微气泡减阻率.     

The quasitriangular structures of biproduct bialgebra

If H is a bialgebra, B is a left H-module algebra and a left H-comodule coalgebra, the smash product algebra structure and the smash coproduct coalgebra [1]structure over BH can form a bialgebra in certain conditions [2],called biproduct and denoted by BH.We present the formulas of quasitrangular structure of biproduct if it contains a quasitrangular structure.We obtain the necessary and sufficient conditions for such that it becomes a quasitriangular bialgebra.     

一种基于激光雷达和视觉的行人检测方法

针对一般城市环境的道路交通安全问题,提出了一种联合激光雷达和视觉的行人检测方法.利用激光雷达和摄像头坐标之间的透视变换关系,将环境的深度信息映射到图像中,并使用航位角推算方法同步激光雷达和摄像头,然后提取兴趣区域.在激光雷达聚类过程中,提出了一种基于行人宽度信息的目标分割方法,能有效分割并排行人.在基于视觉的行人检测中,首先根据行人边缘对称性的特点,预处理兴趣区域,然后采用基于Hausdorff距离的模板匹配方法,根据激光雷达的深度信息匹配行人上半身模板.实验结果表明,该方法可以取得较理想的效果.     

基于模糊故障树的燃料电池发动机氢安全

针对燃料电池发动机的安全可靠性,分析了氢安全和电安全的基本要求及其影响因素,重点从氢安全角度建立了以氢气泄露为顶事件的故障树模型.考虑到底事件和中间事件发生故障概率的模糊性和不确定性,将模糊数学和故障树分析法相结合,对底事件的故障概率进行模糊化并计算了顶事件发生的模糊概率;然后,采用模糊数中值法进行了各底事件的模糊重要度分析,找出了燃料电池发动机安全性的薄弱环节并提出了相关整改措施.研究结果表明,该方法较之传统故障树分析法实用、有效,对提高燃料电池发动机的可靠性与安全性设计具有指导作用.     

改进的引导式邻域搜索算法求解周期性车辆路径问题

在引导式邻域搜索算法静态惩罚策略的基础上,提出动态惩罚策略,设计改进的引导式邻域搜索算法,将其用于求解周期性车辆路径问题,采用标准算例进行数据实验,对动态与静态的惩罚策略进行对比.结果表明,采用改进的引导式邻域搜索算法求解周期性车辆路径问题可行有效.     

一种改进的M元扩频通信算法

针对采用码相位循环移位获得的M元扩频需要额外同步信息的问题,提出一种改进型扩频通信算法.该算法采用m序列及其倒序序列构成系统扩频码集;在同相支路上利用扩频码的码极性调制进行传输,同时在正交支路利用扩频码码相位调制,实现M元扩频.该算法利用2种扩频方式的自身特点可快速准确地获取载波相位信息,具有不需要额外提供同步资源的优势.仿真结果表明,该算法可有效提高系统资源的利用率.