Juxtaposed regions of extensive and minimal linkage disequilibrium in human Xq25 and Xq28

Linkage disequilibrium (LD), or the non-random association of alleles, is poorly understood in the human genome. Population genetic theory suggests that LD is determined by the age of the markers, population history, recombination rate, selection and genetic drift. Despite the uncertainties in determining the relative contributions of these factors, some groups have argued that LD is a simple function of distance between markers. Disease-gene mapping studies and a simulation study gave differing predictions on the degree of LD in isolated and general populations. In view of the discrepancies between theory and experimental observations, we constructed a high-density SNP map of the Xq25-Xq28 region and analysed the male genotypes and haplotypes across this region for LD in three populations. The populations included an outbred European sample (CEPH males) and isolated population samples from Finland and Sardinia. We found two extended regions of strong LD bracketed by regions with no evidence for LD in all three samples. Haplotype analysis showed a paucity of haplotypes in regions of strong LD. Our results suggest that, in this region of the X chromosome, LD is not a monotonic function of the distance between markers, but is more a property of the particular location in the human genome.     

论科学道德建设

科学道德失范的原因主要包括传统文化中消极因素的影响、科技体制和制度措施不够健全、科学道德教育的缺失等。树立和践行社会主义荣辱观是加强科技工作者科学道德建设的核心。科技工作者要以求实创新为荣、以弄虚作假为耻;要加强科学道德规范的约束,强化科技工作者的自律教育,完善科学道德硬件建设,改革我国现行的学术体制,淡化学术研究领域中的行政管理方式,加强媒体监督,纯洁学术氛围。     

EPS控制单元频响特性测试与系统辨识

控制器是电动助力转向系统（EPS）的核心部件之一。EPS控制器采集转向盘扭矩信号和车速信号,由事先设定的算法来计算控制助力电机的目标电流作为输出,并以PWM（脉宽调制波）的形式作用于助力电机。以某国外控制器的EPS实验台架实测数据为基础,在MATLAB软件平台上,建立离散数据分析模型,计算出待测系统的传递函数。将辨识出的传递函数用于EPS开发,实验证明辨识方法是有效的且辨识结果可指导控制软件设计。     

风力发电和飞轮储能联合系统的模糊神经网络控制策略

针对于风力发电和飞轮储能联合系统,提出了一种新的控制策略。基于飞轮储能系统里矢量控制的感应电机,建立了系统的数学模型。在系统里,采用模糊神经网络控制算法实现直流总线电压的自动调整,达到稳定系统的直流总线电压的目的。仿真和实验结果证明,在风力发电和飞轮储能联合系统的能量控制过程中使用模糊神经网络控制算法实现了能量的快速存储和释放,起到了稳定系统电压的作用,取得了满意的控制效果。     

正确认识汽车燃油经济性

汽车的油耗影响到国家经济和战略安全,更直接关系到消费者的使用成本.2006年国家发改委发布了"轿车产品燃油消耗量(油耗)公告",公布了31个厂家407种相关车型的"测试油耗",引起各方的态度不一.但从节约能源和环保来看,降低汽车燃油消耗是汽车制造厂家和使用者的一个永恒课题,因此有必要正确认识汽车燃油经济性.     

医药院校就业创业指导队伍建设研究——以沈阳药科大学为例

近年来,随着各大高校逐步扩大教育培养规模,大学生的就业形势变得十分严峻,就业难的现实似乎已经成为一个阻碍教育事业继续发展的瓶颈性问题,并已成为社会普遍关注的问题.就业创业指导人员的专业知识和能力不足,就业创业指导队伍的建设等问题亟需探讨,并且势在必行.该文基于沈阳药科大学视角浅谈我国医药院校就业创业指导队伍建设.     

基于高职院校人才培养目标的专业科技型学生社团研究

研究专业科技型学生社团与高职院校人才培养目标紧密结合的运作模式，提出“比赛型”和“创业型”学生社团建设在思路、师资配备、场所和经费等方面的难点及解决途径，以期为高职院校实现人才培养目标提供一些建议。     

Natural variation at Strubbelig Receptor Kinase 3 drives immune-triggered incompatibilities between Arabidopsis thaliana accessions

Accumulation of genetic incompatibilities within species can lead to reproductive isolation and, potentially, speciation. In this study, we show that allelic variation at SRF3 (Strubbelig Receptor Family 3), encoding a receptor-like kinase, conditions the occurrence of incompatibility between Arabidopsis thaliana accessions. The geographical distribution of SRF3 alleles reveals that allelic forms causing epistatic incompatibility with a Landsberg erecta allele at the RPP1 resistance locus are present in A. thaliana accessions in central Asia. Incompatible SRF3 alleles condition for an enhanced early immune response to pathogens as compared to the resistance-dampening effect of compatible SRF3 forms in isogenic backgrounds. Variation in disease susceptibility suggests a basis for the molecular patterns of a recent selective sweep detected at the SRF3 locus in central Asian populations.     

B超在肝脾包膜下血肿保守治疗中的应用分析（附21例报告）

肝脾包膜下血肿，症状不典型，但具潜在大出血危象。早期确诊后结合连续超声动态观察，能及时掌握损伤脏器的伤情变化，指导临床治疗，减少加重出血因素，使部分病变得以恢复，从而避免手术打击。本文分析我院从１９９４年１月至１９９９年１２月２１例肝脾包膜下血肿保守治疗中Ｂ超的应用。