基于车队稳定性的安全时距及其确定方法

为确定车辆自适应巡航控制的安全时距,以互连系统稳定性理论为基础,提出了一种基于车队稳定性的安全时距.在建立车辆跟随控制模型的基础上,分析了车队的局部稳定性,进而研究了安全时距与车队全局稳定性之间的关系,给出了基于车队稳定性的安全时距的确定方法.仿真实验结果表明,采用基于车队稳定性的安全时距,能够在不同条件下保证车队中所有车辆的安全性.     

Target mimicry provides a new mechanism for regulation of microRNA activity

MicroRNAs (miRNA) regulate key aspects of development and physiology in animals and plants. These regulatory RNAs act as guides of effector complexes to recognize specific mRNA sequences based on sequence complementarity, resulting in translational repression or site-specific cleavage. In plants, most miRNA targets are cleaved and show almost perfect complementarity with the miRNAs around the cleavage site. Here, we examined the non-protein coding gene IPS1 (INDUCED BY PHOSPHATE STARVATION 1) from Arabidopsis thaliana. IPS1 contains a motif with sequence complementarity to the phosphate (Pi) starvation-induced miRNA miR-399, but the pairing is interrupted by a mismatched loop at the expected miRNA cleavage site. We show that IPS1 RNA is not cleaved but instead sequesters miR-399. Thus, IPS1 overexpression results in increased accumulation of the miR-399 target PHO2 mRNA and, concomitantly, in reduced shoot Pi content. Engineering of IPS1 to be cleavable abolishes its inhibitory activity on miR-399. We coin the term 'target mimicry' to define this mechanism of inhibition of miRNA activity. Target mimicry can be generalized beyond the control of Pi homeostasis, as demonstrated using artificial target mimics.     

Involvement of small Ras GTPases and their effectors in chronic renal disease

The mechanisms involved in the development of renal fibrosis are poorly understood. Small Ras GTPases control cell proliferation, differentiation, cellular growth and apoptosis, with cell-specific expression in the kidney. Cytokines, high glucose medium or advanced glycation end-products activate Ras in different renal cells. Increased Ras activation has been found in experimental tubulointerstitial fibrosis. Transforming growth factor-β1 (TGF-β1) and Ras signalling pathways are close related: TGF-β1 overcomes Ras mitogenic effects, and Ras counteracts TGF-β signalling. However, Ras activation is also an intracellular signal transduction point for several molecules (e.g. TGF-β1) involved in kidney damage. Ras isoforms play different roles in regulating extracellular matrix synthesis in fibroblasts and mesangial cells. These data give evidence for a role for Ras in renal fibrosis, but no reviews are available on the role of p21 Ras in this process. Thus, our goal is to review the role of Ras activation and signalling in renal fibrosis. Received 7 June 2007; received after revision 17 September 2007; accepted 1 October 2007     

基于LH矩法的半潜式平台气隙响应极值分析

以设计水深为1.5km的半潜式平台为研究对象,假设相对波浪升高峰值服从双参数Weibull分布,引入LH矩法,通过模型试验数据对分布中的未知参数进行估计,得到相应的超越概率分布曲线.分析结果表明:随着LH矩阶数的增加,双参数Weibull分布可以很好地拟合非线性较弱的一年一遇海况下相对波浪升高较大部分峰值,对于百年一遇海况下非线性较强的相对波浪升高较大部分峰值,拟合程度也显著改善.     

The Engel''s theorem for braided lie algebras

Throughout this paper, let H be a Hopf algebra. About the properties and conceptions of braided Lie algebras, we refer to [1].     

一种基于低频水声传播特性的浅海地声参数反演方法研究

针对浅海海底声学参数的获取问题,本文研究了一种基于低频水声传播特性的地声参数反演方法。以单水听器接收到各距离点上的复声压为研究对象,通过快速场方法(Fast Field Method,FFM)计算曲线预报结果,依据似然函数建立其与实测数据间的目标函数,最后应用模拟退火算法(Simulated Annealing,SA)寻优得到实测环境下参数最优解。数值模拟与水池实验处理结果均验证了本方法的有效性。     

基于铺层参数的复合材料耐压壳协同优化设计

在给定的材料性能条件下,以耐压壳纤维体积分数和层合板厚度为设计变量,以结构质量最小为优化目标进行复合材料耐压壳的布局优化;以铺层参数作为优化变量,综合考虑结构的稳定性及其材料强度,实现了结构铺层方式的优化设计;通过协调各子系统优化结果,实现了适用于潜水器复合材料耐压壳结构/材料一体化的协同优化设计.结果表明:耐压壳结构质量较优化前的降幅为20.57%,临界失稳压力为30.78MPa,失效指数为0.675,优化结果达到预期效果.所提出的基于铺层参数的协同优化方法能够对复合材料耐压壳进行优化设计,解决了直接以铺层角作为设计变量的优化效率低的问题.     

Advance of High-field Physics-Ultra-short Intense Laser-plasma as New Source of Energetic Particle and Intense Radiation

The ultrashort intense laserplasma interaction has been a rapidly evolving field for last decade, known as highfield physics among many other research frontiers.