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31.
David H. Hubel 《自然科学进展(英文版)》2007,17(13):1-3
The visual field is topographically mapped onto the primary visual cortex (V1), forming a retinotopic map which is far more detailed for the foveal regions than for the periphery. We found that receptive field (RF) size in monkey V1 increases with eccentricity, and that a 1—2 m2 V1 region contains roughly a complete set of machinery necessary to analyze a visual-field area whose size is about that of the RFs of the cells. This allows V1 to be anatomically uniform, and is in sharp contrast with the retina. 相似文献
32.
Rogaeva E Meng Y Lee JH Gu Y Kawarai T Zou F Katayama T Baldwin CT Cheng R Hasegawa H Chen F Shibata N Lunetta KL Pardossi-Piquard R Bohm C Wakutani Y Cupples LA Cuenco KT Green RC Pinessi L Rainero I Sorbi S Bruni A Duara R Friedland RP Inzelberg R Hampe W Bujo H Song YQ Andersen OM Willnow TE Graff-Radford N Petersen RC Dickson D Der SD Fraser PE Schmitt-Ulms G Younkin S Mayeux R Farrer LA St George-Hyslop P 《Nature genetics》2007,39(2):168-177
The recycling of the amyloid precursor protein (APP) from the cell surface via the endocytic pathways plays a key role in the generation of amyloid beta peptide (Abeta) in Alzheimer disease. We report here that inherited variants in the SORL1 neuronal sorting receptor are associated with late-onset Alzheimer disease. These variants, which occur in at least two different clusters of intronic sequences within the SORL1 gene (also known as LR11 or SORLA) may regulate tissue-specific expression of SORL1. We also show that SORL1 directs trafficking of APP into recycling pathways and that when SORL1 is underexpressed, APP is sorted into Abeta-generating compartments. These data suggest that inherited or acquired changes in SORL1 expression or function are mechanistically involved in causing Alzheimer disease. 相似文献
33.
The interleukin 1β (IL-1β) cDNA was cloned from the red seabream (Pagrus major) by homology cloning strategy. A cDNA fragment was amplified by PCR using two degenerated primers, which were designed according to the conserved regions of other known IL-1β sequences, and elongated by 3' ends and 5' ends RACE PCR to get the full length coding sequence of red seabream IL-1β (RS IL-1β). The sequence contained 1252 nucleotides that included a 5' untranslated region (UTR) of 84bp, a 3' UTR of 410 bp and an open reading frame (ORF) of 759 nucleotides which could be translated into a putative peptide of 253 amino acids with molecular weight of 28.6 kD and putative isoelectric point pI of 5.29. The deduced peptide contained two potential N-glycosylation sites and an identifiable IL1 family signature, but lacked the signal peptide and the clear ICE cut site, which were common in other nonmammalian IL-1β genes. The RS IL-1β had the highest homology with piscine IL-1β according to phylogenetic tree analysis. 相似文献
34.
一、缺血性心脏病与前列腺素、凝血(口恶)烷(thrombaxane)缺血性心脏病的发病及加重与动脉硬化、血栓形成和冠状动脉痉挛的关系是十分重要的。所以具有强血管扩张作用和血小板凝集抑制作用的环前列腺素和相反的具有强血管收缩作用及血小板凝集作用的凝血(口恶)烷 A_(TXA_2)两种物质与缺血性心脏病的关系已引人重 相似文献
35.
36.
在《魔兽争霸3》中,Human一直是以防御见长的种族。Footman抵挡穿刺攻击的Defense技能,Paladin的防御光环和Priest的Inner Fire魔法都是用以加强部队防御力量的。而且Human是《魔兽争霸3》中综合移动速度最慢的种族。不但只有Knight具有比较快的移动速度,而且没有任何加速的光环和魔法加以辅助。基于Human的这种特点,以 相似文献
38.
39.
GIS-Based Mapping and Zonation of Landslide Hazards in Xiaojiang Valley of Southwestern China 总被引:3,自引:0,他引:3
MaZe-zhong HeYi-ping XieHong CuiPeng ZhongDun-lun JamesS.Gardner 《武汉大学学报:自然科学英文版》2003,8(3B):1021-1028
Through the field survey, previous researches and interpretation of aerial photos, a landslide information database of Xiaojiang Valley, Yurman Province was set up based on the remote sensing (RS) and geographic information system (GIS) technologies. In the paper, a quantitative model for the landslide hazard assessment and zoning was presented,in which the potential energy could be obtained on basis of thorough analysis of the potential sliding volume, distance and direction of the landslide body. Taking landslide potential energy as the index of the hazard severity zonation, the study area was divided into severe, heavy, medium and light hazard zones. 相似文献
40.