Biosynthesis of 1-aminocyclopropanecarboxylic acid: Steric course of the reaction at the C-4 position

Summary Under the action of the appropriate synthase from ripe tomatoes a 11 mixture of (3S, 4R)-[3,4-²H₂] and (3R, 4S)-[3,4-²H₂]-(2S)-adenosylmethionine is transformed into a 11 mixture of the two meso forms of [²H₂]-1-aminocyclopropanecarboxylic acid, a result which proves the operation of an inversion mechanism and which is consistent with direct nucleophilic displacement of the leaving group in the substrate.     

Position of the Y-chromosome at somatic metaphase in patients with chronic myelogenous leukemia (CML)

Summary A random distribution of the Y-chromosome at somatic metaphase was found in 50 patients with Ph' positive chronic myelogenous leukemia (CML). Thus, it is concluded that the positive of the Y-chromosome at somatic metaphase does not appear to influence the loss from bone marrow cells.     

Hormonal induction of steroid sulphatase in the mouse

Summary By comparing steroid sulphatase levels per se, and also ratios to -galactosidase, in 6 sets of mice — normal females, entire and castrated males both with and without exogenous testosterone administration — we obtained support for the contention that induction of this enzyme is in part controlled by male hormones.     

Bromocriptine-induced removal of endoplasmic membranes from prolactinoma cells

Summary Adenomatous prolactin cells lose 39% of their cytoplasm volume within 7 days after the beginning of bromocriptine treatment. A simultaneous reduction of the rough-surfaced endoplasmic reticulum and the Golgi apparatus occurs. Their membranes are removed by rapid transport along the secretory pathway to the cell surface and to lysosomal destruction.We thank Prof. E. del Pozo, Sandoz Ltd, Basle, for the generous gift of injectable bromocriptine, Prof. E.R. Weibel, Dept. of Anatomy, University of Bern, for his technical advice, Dr U. Helfenstein, Institute of Biostatistics, University of Zürich, for his help in the statistical evaluation of the results and the EMDO-Foundation, Zürich, for financial support.     

In vitro mutagenicity testing of a potent,new, benzoyl urea insect growth regulator

Summary Bacterial mutagenicity assay to detect potential chronic toxicity of a potent, new, benzoyl urea insect growth regulator (CGA-112913 or IKI-7899, formerly UC-62644) was conducted using 5 histidine auxotrophs ofSalmonella typhimurium. Tests within the concentration range of 0.9–500 g (saturating)/plate of the compound with and without the 5–9 mammalian metabolic activation system showed no mutagenic effects clearing the way for long-term chronic toxicology studies.The authors thank Professor Bruce N. Ames for supplying the tester strains together with all the relevant information for conducting the bioassays and Ms. Norma Charlebois for her meticulous technical assistance.     

Adrenocortical metabolism and plasma corticosterone in soman intoxicated rabbits

Summary The organophosphate neurotoxin soman produced impairments in adrenocortical RNA and protein metabolism. Fasciculate and reticular cell RNA and protein contents were supporessed with sublethal to acutely lethal dosages (20, 30 and 40 g/kg, s.c.) during the acute excitatory phase of intoxication and at 6–8 h post injection. All three dosages produced ca 90% inactivation of plasma cholinesterase. A transient elevation of plasma corticosterone occurred with 20 g/kg soman whereas there was a protracted increase with 30 g/kg. Corticosterone was not significantly elevated with 40 g/kg, but death occurred at 13±4 min. Thus, the magnitude and/or nature of soman-induced metabolic impairments does not appear to prevent adrenal activation.Supported by US Army Medical Research and Development Command Contract DAMD 17-81-C-1202.     

边界层对粗糙单裂隙溶质运移影响试验

为探究非费克(non-Fickian)运移表现出的峰值提前到达和拖尾等现象,开展了粗糙单裂隙溶质运移试验,总结了粗糙单裂隙中溶质运移特征及运移机理,结合边界层理论对峰值提前到达和拖尾现象进行了分析和解释。结果表明：峰值时间和拖尾时间与边界层厚度之间存在较好的线性相关关系;边界层对裂隙介质溶质运移有较为显著影响,即水流速度越小,边界层厚度越大,滞留在边界层内部的溶质越多,溶质获取率越低;粗糙单裂隙中溶质穿透曲线的峰值提前和拖尾现象是由裂隙中心处以惯性力主导的主流区和裂隙壁面以黏性力主导的边界层区共同作用造成的,其中峰值时间主要由主流区的对流因素控制,而边界层区域的存在对拖尾时间影响较大。     

基于双重匹配注意力网络的观点型阅读理解

提出一种基于双重匹配注意力网络的方法.先用动态匹配机制迭代综合获取全局观点信息,同时利用多维度匹配机制在不同特征空间上计算全局语义信息,然后交互式多路注意力机制通过两路注意力之间的交互计算对上述全局的观点与语义信息进行融合,最后与选项表示结合预测答案的观点倾向.在观点型阅读理解数据集ReCO和Dureader上面的实验表明,该方法相对于基准模型在准确率上提升了1.18%和0.84%,在加权宏F1上提升了1.16%和0.75%.     

基于机器视觉的车辆时空参数识别

车辆荷载信息是分析桥梁受力和性能评估的重要依据,其中车辆时空信息是准确识别车辆荷载的关键参数。考虑到传统在桥面埋设传感器的方法影响交通、破坏路面,提出了一种基于机器视觉技术的车辆荷载时空参数识别方法,包括车辆的横向定位、车速、车轴数、轴距的识别。基于正面拍摄视频,采用背景差分法来实现车辆检测,进一步通过车牌识别确定车辆在图像中的位置,然后根据车牌与车道线距离来实现车辆横向定位。基于侧面拍摄视频,采用图像标定方法,结合已知长度的辅助检测线来获取车辆的轴距、轴数、车速等车辆参数。通过试验室模型试验和现场试验验证了提出的方法。结果表明,现场试验中车辆横向定位和车速的最大误差分别为2.42%和2.67%,轴距的平均误差为1.63%,识别结果可以为更多其他车辆参数如轴重和总重的识别提供重要的技术支撑。