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排序方式: 共有127条查询结果,搜索用时 718 毫秒
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P. Souza Santos A. Vallejo-Freire J. Parsons J. H. L. Watson 《Cellular and molecular life sciences : CMLS》1958,14(9):318-320
Résumé Les auteurs démontrent que le gel d'hydroxyde d'aluminium (gel deSchmidt) soumis aux rayons X diffractés et examiné au microscope électronique se révèle formé de particules différant par leur structure, leur morphologie et leur dimensions de celles du gel C-gamma deWillstätter, mais semblables à celles du gel C-béta du même nom. 相似文献
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Sandilands A Terron-Kwiatkowski A Hull PR O'Regan GM Clayton TH Watson RM Carrick T Evans AT Liao H Zhao Y Campbell LE Schmuth M Gruber R Janecke AR Elias PM van Steensel MA Nagtzaam I van Geel M Steijlen PM Munro CS Bradley DG Palmer CN Smith FJ McLean WH Irvine AD 《Nature genetics》2007,39(5):650-654
We recently reported two common filaggrin (FLG) null mutations that cause ichthyosis vulgaris and predispose to eczema and secondary allergic diseases. We show here that these common European mutations are ancestral variants carried on conserved haplotypes. To facilitate comprehensive analysis of other populations, we report a strategy for full sequencing of this large, highly repetitive gene, and we describe 15 variants, including seven that are prevalent. All the variants are either nonsense or frameshift mutations that, in representative cases, resulted in loss of filaggrin production in the epidermis. In an Irish case-control study, the five most common European mutations showed a strong association with moderate-to-severe childhood eczema (chi2 test: P = 2.12 x 10(-51); Fisher's exact test: heterozygote odds ratio (OR) = 7.44 (95% confidence interval (c.i.) = 4.9-11.3), and homozygote OR = 151 (95% c.i. = 20-1,136)). We found three additional rare null mutations in this case series, suggesting that the genetic architecture of filaggrin-related atopic dermatitis consists of both prevalent and rare risk alleles. 相似文献
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Effect of iron supply on Southern Ocean CO2 uptake and implications for glacial atmospheric CO2 总被引:18,自引:0,他引:18
Photosynthesis by marine phytoplankton in the Southern Ocean, and the associated uptake of carbon, is thought to be currently limited by the availability of iron. One implication of this limitation is that a larger iron supply to the region in glacial times could have stimulated algal photosynthesis, leading to lower concentrations of atmospheric CO2. Similarly, it has been proposed that artificial iron fertilization of the oceans might increase future carbon sequestration. Here we report data from a whole-ecosystem test of the iron-limitation hypothesis in the Southern Ocean, which show that surface uptake of atmospheric CO2 and uptake ratios of silica to carbon by phytoplankton were strongly influenced by nanomolar increases of iron concentration. We use these results to inform a model of global carbon and ocean nutrients, forced with atmospheric iron fluxes to the region derived from the Vostok ice-core dust record. During glacial periods, predicted magnitudes and timings of atmospheric CO2 changes match ice-core records well. At glacial terminations, the model suggests that forcing of Southern Ocean biota by iron caused the initial approximately 40 p.p.m. of glacial-interglacial CO2 change, but other mechanisms must have accounted for the remaining 40 p.p.m. increase. The experiment also confirms that modest sequestration of atmospheric CO2 by artificial additions of iron to the Southern Ocean is in principle possible, although the period and geographical extent over which sequestration would be effective remain poorly known. 相似文献
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H. Smith G. A. Hughes G. H. Douglas D. Hartley B. J. McLoughlin J. B. Siddall G. R. Wendt G. C. Buzby Jr. D. R. Herbst K. W. Ledig J. R. McMenamin T. W. Pattison J. Suida J. Tokolics R. A. Edgren A. B. A. Jansen B. Gadsby D. H. R. Watson P. C. Phillips 《Cellular and molecular life sciences : CMLS》1963,19(8):394-396
Zusammenfassung Von mehreren (±) 3-Oxy- und (±) 3-Methoxy-13-alkylgona-1,3,5(10)trien-17-onen und verwandten Verbindungen, einschliesslich von Vertretern der (±) 13-Alkylgon-4-en-3-on-Reihe, werden Totalsynthese und biologische Wirksamkeit beschrieben. 相似文献