四川省山区城镇山洪灾害特征分析

四川省山区城镇山洪灾害分为溪河洪水、泥石流、溪河洪水 泥石流与溪河洪水 泥石流 滑坡四种类型.通过对近50年四川省受山洪灾害危害的典型山区城镇进行调查,从灾害的爆发频率、威胁人口、死亡人口及财产损失四个方面进行相关性分析得出:总体上山洪灾害爆发频率越低,造成的威胁区内人员死亡概率和人均财产损失越大.各类山洪灾害的特征不同:溪河洪水爆发频率高,造成人员伤亡较小,财产损失较大;泥石流的爆发频率低,人员伤亡大,财产损失较大;泥石流 溪河洪水的综合灾害爆发频次低,人员伤亡和财产损失相对较大;泥石流 滑坡 溪河洪水的综合灾害爆发频次最低,威胁人口最多,造成人员伤亡和财产损失都很大.     

Request Dispatching Algorithms for Web Server Clusters Based on Load Balancing

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The Pendred syndrome gene encodes a chloride-iodide transport protein

Pendred syndrome is the most common form of syndromic deafness and characterized by congenital sensorineural hearing loss and goitre. This disorder was mapped to chromosome 7 and the gene causing Pendred syndrome (PDS) was subsequently identified by positional cloning. PDS encodes a putative transmembrane protein designated pendrin. Pendrin is closely related to a family of sulfate transport proteins that includes the rat sulfate-anion transporter (encoded by Sat-1; 29% amino acid sequence identity), the human diastrophic dysplasia sulfate transporter (encoded by DTD; 32%) and the human sulfate transporter 'downregulated in adenoma' (encoded by DRA; 45%). On the basis of this homology and the presence of a slightly modified sulfate-transporter signature sequence comprising its putative second transmembrane domain, pendrin has been proposed to function as a sulfate transporter. We were unable to detect evidence of sulfate transport following the expression of pendrin in Xenopus laevis oocytes by microinjection of PDS cRNA or in Sf9 cells following infection with PDS-recombinant baculovirus. The rates of transport for iodide and chloride were significantly increased following the expression of pendrin in both cell systems. Our results demonstrate that pendrin functions as a transporter of chloride and iodide, but not sulfate, and may provide insight into thyroid physiology and the pathophysiology of Pendred syndrome.     

降压后排球的技术特征分析

本文通过对降压前、后排球的力学实验研究与理论分析,提出降压后排球的相应技术特征,来适应当今排球比赛发展的要求。     

The DNA sequence and analysis of human chromosome 13

Chromosome 13 is the largest acrocentric human chromosome. It carries genes involved in cancer including the breast cancer type 2 (BRCA2) and retinoblastoma (RB1) genes, is frequently rearranged in B-cell chronic lymphocytic leukaemia, and contains the DAOA locus associated with bipolar disorder and schizophrenia. We describe completion and analysis of 95.5 megabases (Mb) of sequence from chromosome 13, which contains 633 genes and 296 pseudogenes. We estimate that more than 95.4% of the protein-coding genes of this chromosome have been identified, on the basis of comparison with other vertebrate genome sequences. Additionally, 105 putative non-coding RNA genes were found. Chromosome 13 has one of the lowest gene densities (6.5 genes per Mb) among human chromosomes, and contains a central region of 38 Mb where the gene density drops to only 3.1 genes per Mb.     

Duplicate genes increase gene expression diversity within and between species

Using microarray gene expression data from several Drosophila species and strains, we show that duplicated genes, compared with single-copy genes, significantly increase gene expression diversity during development. We show further that duplicate genes tend to cause expression divergences between Drosophila species (or strains) to evolve faster than do single-copy genes. This conclusion is also supported by data from different yeast strains.     

调制式旋转导向系统导向力"等力合成模型"的建立与分析

导向力的形成机理是研制旋转导向工具的核心。在深入研究国外旋转导向工具的基础上,参考导弹制导原理,提出了调制式旋转导向工具新的导向方式,建立了导向力"等力合成模型",并对其影响规律进行了分析。结果表明,这种导向方式与PowerDriveSRD导向系统相比,有其独特的优点。控制面不稳定程度对合导向力的影响并不很大,在控制面摆动度达14°时,合导向力仅下降1%。这为调制式旋转导向工具稳定平台的研制提供了宽松的约束条件。     

Amplification of immunoglobulin lambda constant genes in populations of wild mice

The lambda immunoglobulin light chain (Ig lambda) locus of BALB/c inbred mice consists of two variable region gene segments (V lambda)1-3, and four constant region gene segments (C lambda)1,2,4,5. Each C lambda gene segment is associated with a unique joining segment (J lambda)2,4-7, and they are organized in two paired units, J3C3-J1C1 and J2C2-J4C4 (refs 4, 8). Using cDNA probes specific for C lambda 1 and C lambda 2 (ref. 9) we have analysed the genomic organization of the C lambda gene segments in wild-derived and inbred strains of mice. Although Southern blots of the genomic DNA of inbred mice show a constant pattern of hybridization, wild-derived mice show a high degree of variation in the number, size and intensity of hybridizing fragments. We have now found that, per haploid genome, mice of a Mus musculus musculus stock isolated from Sladeckovce, Czechoslovakia (CzII) have at least 12 C lambda segments, and mice of a Mus musculus domesticus stock 'Centreville Lights' from Centreville, Maryland (CL) have at least 8 C lambda segments. There appears to have been relatively recent amplifications of the C lambda gene segments in wild mice.