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991.
Summary In rats adapted to a 1212 h light-dark (LD) schedule, cyclic AMP concentration in the preoptic region showed a L minimum and D maximum. No significant fluctuations were observed in the parietal cortex.Supported by grant No. 79.01946.04 awarded by the National Research Council (CNR), Rome, Italy.  相似文献   
992.
Zusammenfassung Es wird die Isolierung eines neuen fluoreszierenden Thiaminderivates beschrieben.  相似文献   
993.
994.
Autosomal recessive spastic ataxia of Charlevoix-Saguenay (ARSACS or SACS) is an early onset neurodegenerative disease with high prevalence (carrier frequency 1/22) in the Charlevoix-Saguenay-Lac-Saint-Jean (CSLSJ) region of Quebec. We previously mapped the gene responsible for ARSACS to chromosome 13q11 and identified two ancestral haplotypes. Here we report the cloning of this gene, SACS, which encodes the protein sacsin. The ORF of SACS is 11,487 bp and is encoded by a single gigantic exon spanning 12,794 bp. This exon is the largest to be identified in any vertebrate organism. The ORF is conserved in human and mouse. The putative protein contains three large segments with sequence similarity to each other and to the predicted protein of an Arabidopsis thaliana ORF. The presence of heat-shock domains suggests a function for sacsin in chaperone-mediated protein folding. SACS is expressed in a variety of tissues, including the central nervous system. We identified two SACSmutations in ARSACS families that lead to protein truncation, consistent with haplotype analysis.  相似文献   
995.
Zusammenfassung Die Infektion der Blätter vonCapsicum annuum undMangifera indica mit den BlattpilzenCurvularia ovoidea beziehungsweiselunata hat zur Folge, dass die freien Zucker Saccharose, Glukose und Fruktose verschwinden und dass der Gehalt an organischen Säuren (Apfelsäure, Zitronensäure, Oxalsäure) vermindert wird.  相似文献   
996.
Intestinal morphogenesis and differentiation are dependent on heterotypic cell interactions between embryonic epithelial cells (endoderm) and stromal cells (mesenchyme). Extracellular matrix molecules represent attractive candidates for regulators of these interactions. The structural and functional diversity of the extracellular matrix as intestinal development proceeds is demonstrated by 1) spatio-temporal specific expression of the classically described constituents, 2) the finding of laminin and collagen IV variants, 3) changes in the ratio of individual constituent chains, and 4) a stage-specific regulation of basement membrane molecule production, in particular by glucocorticoids. The orientation/assembly of these extracellular matrix molecules could direct precise cellular functions through interactions via integrin molecules. The involvement of extracellular matrix, and in particular basement membrane molecules in heterotypic cell interactions leading to epithelial cell differentiation, has been highlighted by the use of experimental models such as cocultures, hybrid intestines and antisense approaches. These models allowed us to conclude that a correct elaboration and assembly of the basement membrane, following close contacts between epithelial and fibroblastic cells, is necessary for the expression of differentiation markers such as digestive enzymes.  相似文献   
997.
Substance P and choline acetyltransferase have been localised in a small proportion of endothelial cells of rat coronary arteries using electron microscopic immunocytochemistry. During a hypoxic period of 1 min, coronary vasodilatation was produced in the Langendorff heart preparation and increased levels of substance P and acetylcholine were released into the perfusate. The possibility that these substances are released from endothelial cells during hypoxia and contribute to the hyperaemic response is discussed.  相似文献   
998.
Interleukin-1 (Il-1) was added to collagen lattice cultures of human skin fibroblasts. No cell division was induced, the ability of fibroblasts to contract the lattices was decreased and a dose-related inhibition of collagen synthesis without effect on non-collagen proteins was found. Indomethacin had no influence on these effects.  相似文献   
999.
1.INTRODUCTION Manyreal worldsystemscanbemodeledaslinearpa rameter varying(LPV)systems[1],whosestate spacerepresentationmatricesarefunctionsofasetof parametersthataremeasurableinrealtime.Recent ly,manyresearchersathomeandabroadhavebeen engagedinthestabilityanalysisandgainscheduling controlofLPVsystemsextensivelyandagreatnum berofimportantresultshavebeenreportedinthelit erature(see,forinstance,Refs.[1~7]andtheref erencestherein).Mostoftheseresultsfocusoncon tinuous timecases,while…  相似文献   
1000.
1 .INTRODUCTIONBP methodis a widely used classical learning algo-rithmof Neural Networks . Whileit has two short-ages ,i .e .slowconvergence rate and existinglocalmini mum of the cost function. Many new algo-rithms such as modification methods of BP meth-od, conjugate gradient methods , RLS methods ,quasi-Newton methods , evolving learning meth-ods ,chaos-learning algorithms have been proposedso far[1 ~7]. However ,these novel algorithms neverdirectly utilize the 2-ed order differentia…  相似文献   
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