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81.
Localization of the c-ab1 oncogene adjacent to a translocation break point in chronic myelocytic leukaemia 总被引:67,自引:0,他引:67
N Heisterkamp J R Stephenson J Groffen P F Hansen A de Klein C R Bartram G Grosveld 《Nature》1983,306(5940):239-242
The human c-ab1 oncogene maps within the region (q34-qter) of chromosome 9 which is translocated to chromosome 22, the Philadelphia (Ph') chromosome, in chronic myelocytic leukaemia (CML). The position of the Ph' chromosomal break point is shown to be variable and, in one CML patient, has been localized immediately 5' of, or within, the c-ab1 oncogene. A DNA restriction fragment corresponding to this site has been molecularly cloned and shown to represent a chimaeric fragment of DNA from chromosomes 9 and 22. 相似文献
82.
83.
Folic acid levels in blood and seminal plasma of normo- and oligospermic patients prior and following folic acid treatment 总被引:2,自引:0,他引:2
Folic acid was estimated in blood and seminal plasma of normo- and oligospermic men. Following folic acid administration (10 mg TID for 30 days), the levels in blood and semen increased. However, sperm counts, motility and DNA content of spermatozoa were not affected. 相似文献
84.
85.
B. Landau R. Singer T. Klein E. Segenreich 《Cellular and molecular life sciences : CMLS》1978,34(10):1301-1302
Summary Folic acid was estimated in blood and seminal plasma of normo- and oligospermic men. Following folic acid administration (10 mg TID for 30 days), the levels in blood and semen increased. However, sperm counts, motility and DNA content of spermatozoa were not affected. 相似文献
86.
87.
The influence of a) tissue culture medium (RPMI), b) homologous plasma (HP), and c) fetal calf serum (FCS) on lymphocytic cortisol metabolism was compared to that of phosphate buffered saline alone. RPMI was found to enhance the conversion rate 1.71 times, whereas HP and FCS enhanced it about 3.2 times. Raising the temperature of the HP and FCS to 100 degrees C before incubation reduced the enhancing effect to the level of that obtained with RPMI. 相似文献
88.
We investigated the mechanisms for glucocorticoid regulation of rat renal NaK-ATPase activity. Our findings suggest that the magnitudes of corticosterone-induced increases in alpha 1 mRNA and beta 1 mRNA levels are similar in the kidney of the adult adrenalectomized rats. The results also suggest that corticosterone restores NaK-ATPase activity in adrenalectomized rats prior to any enhanced sodium delivery. 相似文献
89.
Evolution of tumours and the impact of molecular oncology 总被引:3,自引:0,他引:3
It is generally accepted that tumours arise through the accumulation of several changes affecting the control of cell growth. Recent advances in molecular biology have made it possible to define some of these changes in molecular terms and to trace the steps by which certain tumours evolve. 相似文献
90.
Herman MA Peroni OD Villoria J Schön MR Abumrad NA Blüher M Klein S Kahn BB 《Nature》2012,484(7394):333-338