Effects of thalidomide in the rat foetus

Zusammenfassung Thalidomidverabreichung an sch wangere Ratten führte zu keinen schweren Skelettmissbildungen bei den Neugeburten. Lediglich der fünfte Brustbeinkern blieb in der Entwicklung stark zurück und zeigte, besonders bei Tieren, welche Thalidomid in hohen Dosen erhielten, bizarre Formen. Die Zahl der Frucht-resorptionen war bei diesen Tieren erhöht.     

Highly purified noradrenaline storage vesicles from bovine splenic nerve trunk: Preliminary electron microscopy

Résumé Les vésicules de la NA du nerf splénique de Buf ont été obtenues par gradient de centrifugation («sucrose-heavy water»), Le rapport NA/protéine observé est de 4 à 7 fois plus élevé que celui qui a été mentionné précédemment. L'examen préliminaire de cette fraction, par microscopie électronique, révèle une couche importante et pratiquement pure de vésicules à la surface du sédiment.

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Supported by Research Career Program Award No. 5-K03-HE-0592 from the Nat. Heart and Lung Inst. and Research Grant No. 5-R01-GM15490 from the Nat. Inst. Gen. Med. Sci., U.S.P.H.S.

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Supported by the Swedish Medical Research Council No. K70-14X-2479-03A and Knut and Alice Wallenbergs Foundation.     

Detection and imaging of atmospheric radio flashes from cosmic ray air showers

The nature of ultrahigh-energy cosmic rays (UHECRs) at energies >10(20) eV remains a mystery. They are likely to be of extragalactic origin, but should be absorbed within approximately 50 Mpc through interactions with the cosmic microwave background. As there are no sufficiently powerful accelerators within this distance from the Galaxy, explanations for UHECRs range from unusual astrophysical sources to exotic string physics. Also unclear is whether UHECRs consist of protons, heavy nuclei, neutrinos or gamma-rays. To resolve these questions, larger detectors with higher duty cycles and which combine multiple detection techniques are needed. Radio emission from UHECRs, on the other hand, is unaffected by attenuation, has a high duty cycle, gives calorimetric measurements and provides high directional accuracy. Here we report the detection of radio flashes from cosmic-ray air showers using low-cost digital radio receivers. We show that the radiation can be understood in terms of the geosynchrotron effect. Our results show that it should be possible to determine the nature and composition of UHECRs with combined radio and particle detectors, and to detect the ultrahigh-energy neutrinos expected from flavour mixing.     

Action d'un hépatome ascitique du rat sur les acides nucléiques du pancréas et du rein

Summary Animals having an ascites hepatoma show an increase in the incorporation of P³² into ribonucleic acid and desoxyribonucleic acid of the pancreas, whereas no change is seen in the kidneys. The variations noted in the pancreas may be compared with those observed previously in the liver and the adrenals. It can therefore be presumed that a substance which stimulates biosynthesis or disrupts the normal metabolic balance is produced by the ascites cells.

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Travail effectué avec l'aide matérielle de l'Institut National d'Hygiène.