CD43, a molecule defective in Wiskott-Aldrich syndrome, binds ICAM-1.

THE protein CD43 (also known as sialophorin, leukosialin, large sialoglycoprotein or gp115) is expressed on the surface of T lymphocytes, monocytes, neutrophils, platelets and some B lymphocytes. Expression of CD43 is deficient and/or defective in the X-chromosome-linked immunodeficiency disorder Wiscott-Aldrich syndrome, suggesting that CD43 might have a role in T-cell activation. We have shown that expression of human CD43 in an HLA-DR-specific murine T-cell hybridoma enhances the antigen-specific response to stimulation by the human lymphoblastoid cell line Daudi, and that Daudi cells bind specifically to purified immobilized CD43. These data indicate that the specific interaction of CD43 with a ligand on the surface of Daudi cells might contribute to T-cell activation. Here we report evidence that intercellular adhesion molecule-1 (ICAM-1, or CD54), is a ligand for CD43.     

Electroencephalography of the olfactory bulb in relation to prespawn homing

Summary remarks It is evident that the bulbar EEG is a complex response which can be influenced by several methodological and stimulant variables. What EEG patterns tell us about actual behavior remains obscure. The bulbar EEG which is evoked by homestream water is not necessarily a reflection of olfactory memory. The evoked bulbar EEG also does not necessarily demonstrate the salmon has distinguished the home-water from another water in terms of migrational orientation. Despite lack of absolute specificity, a correlation between bulbar EEG and actual behavioral performance has been observed even though some non-home waters evoke responses similar to that of the home water. In general it has been found that the home water response can be distinguished from the response to other natural waters. Failure to obtain complete specificity may be due to a variety of variables which have been alluded to earlier in this section. Thus considering that the evoked EEG is a reflection of the integration of a diverse afferent input, further electrical and computer analyses may eventually permit the decoding of the EEG in terms of behavior. However, if the EEG proves to be more a quantitative rather than qualitative reflection of brain activity, relating EEG to behavior will prove to be of limited value. Since afferent responses in the olfactory bulb are influenced by impulses from higher brain centers, studies on centrifugal aspects during olfactory stimulation may be useful in gaining some qualitative understanding of the home water evoked EEG of the olfactory bulb.     

Stabilization of DNA structure by histones against thermal denaturation

Zusammenfassung Durch grösseren Gehalt an Resthiston wird die Stabilität von Desoxyribonucleinsäure gegenüber der thermischen Denaturierung in 0.0025M NaNO₂ erhöht und die Zunahme des ntomaren Extinktionskoeffizienten (P) während der Denaturierung verringert.

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With the aid of a grant from the Schweizerischer Nationalfonds zur Förderung der wissenschaftlichen Forschung and the aid of the Muscular Dystrophy Association of America to Prof.F. Verzár.     

The effect of early weaning on spermiogenesis in adult rats

Zusammenfassung Junge, vorzeitig (18 Tage nach der Geburt entwöhnte Ratten) zeigen im Alter von 12 Monaten Schädigungen im spermiogenen Hodenepithel. 12 Tage später entwöhnte Ratten entwickeln sich normal. Die beobachteten Schädigungen treten im Alter von 6 Monaten noch nicht auf.