排序方式: 共有77条查询结果,搜索用时 317 毫秒
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Lindblad-Toh K Wade CM Mikkelsen TS Karlsson EK Jaffe DB Kamal M Clamp M Chang JL Kulbokas EJ Zody MC Mauceli E Xie X Breen M Wayne RK Ostrander EA Ponting CP Galibert F Smith DR DeJong PJ Kirkness E Alvarez P Biagi T Brockman W Butler J Chin CW Cook A Cuff J Daly MJ DeCaprio D Gnerre S Grabherr M Kellis M Kleber M Bardeleben C Goodstadt L Heger A Hitte C Kim L Koepfli KP Parker HG Pollinger JP Searle SM Sutter NB Thomas R Webber C Baldwin J Abebe A Abouelleil A Aftuck L Ait-Zahra M Aldredge T 《Nature》2005,438(7069):803-819
Here we report a high-quality draft genome sequence of the domestic dog (Canis familiaris), together with a dense map of single nucleotide polymorphisms (SNPs) across breeds. The dog is of particular interest because it provides important evolutionary information and because existing breeds show great phenotypic diversity for morphological, physiological and behavioural traits. We use sequence comparison with the primate and rodent lineages to shed light on the structure and evolution of genomes and genes. Notably, the majority of the most highly conserved non-coding sequences in mammalian genomes are clustered near a small subset of genes with important roles in development. Analysis of SNPs reveals long-range haplotypes across the entire dog genome, and defines the nature of genetic diversity within and across breeds. The current SNP map now makes it possible for genome-wide association studies to identify genes responsible for diseases and traits, with important consequences for human and companion animal health. 相似文献
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K. R. Daly 《Cellular and molecular life sciences : CMLS》1971,27(1):81-83
Zusammenfassung Nach früher akuter Berührung mit-Bestrahlung kann im allgemeinen der Erholungsprozess beiArabidopsis thaliana (L.) Heynh. Samen durch relativ kleine und kurze Umgebungsveränderungen (4°C während 4 Tagen) stark modifiziert werden. Diese werden nach vermeintlicher Deaktivierung radiochemischer Produkte angewendet und beeinflussen nicht nur die behandelte, sondern auch die folgende Generation. 相似文献
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C. R. Creveling J. W. Daly T. Tokuyama B. Witkop 《Cellular and molecular life sciences : CMLS》1969,25(1):26-27
Zusammenfassung Das in vivo leicht hydrolysierbare 0, 0, 0-Triacetat und das zyklische Brenzkatechin-carbonat desl-Noradrenalins setzen im Herzen der Maus tritiiertes Noradrenalin frei. Beide Derivate sowie das 0, 0, 0-Trimethylsilyl-l-noradrenalin-7-3H, sind genügend lipophil, um leicht die Liquorschranke zu überschreiten, wo sie im Zentralnervensystem langsam tritiiertes Noradrenalin freisetzen. Solche Noradrenalin-Depot-Derivate sind möglicherweise von therapeutischem Interesse. 相似文献
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The mosaic structure of variation in the laboratory mouse genome 总被引:56,自引:0,他引:56
Wade CM Kulbokas EJ Kirby AW Zody MC Mullikin JC Lander ES Lindblad-Toh K Daly MJ 《Nature》2002,420(6915):574-578
Most inbred laboratory mouse strains are known to have originated from a mixed but limited founder population in a few laboratories. However, the effect of this breeding history on patterns of genetic variation among these strains and the implications for their use are not well understood. Here we present an analysis of the fine structure of variation in the mouse genome, using single nucleotide polymorphisms (SNPs). When the recently assembled genome sequence from the C57BL/6J strain is aligned with sample sequence from other strains, we observe long segments of either extremely high (approximately 40 SNPs per 10 kb) or extremely low (approximately 0.5 SNPs per 10 kb) polymorphism rates. In all strain-to-strain comparisons examined, only one-third of the genome falls into long regions (averaging >1 Mb) of a high SNP rate, consistent with estimated divergence rates between Mus musculus domesticus and either M. m. musculus or M. m. castaneus. These data suggest that the genomes of these inbred strains are mosaics with the vast majority of segments derived from domesticus and musculus sources. These observations have important implications for the design and interpretation of positional cloning experiments. 相似文献
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Human genome sequence variation and the influence of gene history,mutation and recombination 总被引:25,自引:0,他引:25
Reich DE Schaffner SF Daly MJ McVean G Mullikin JC Higgins JM Richter DJ Lander ES Altshuler D 《Nature genetics》2002,32(1):135-142
Variation in the human genome sequence is key to understanding susceptibility to disease in modern populations and the history of ancestral populations. Unlocking this information requires knowledge of the patterns and underlying causes of human sequence diversity. By applying a new population-genetic framework to two genome-wide polymorphism surveys, we find that the human genome contains sizeable regions (stretching over tens of thousands of base pairs) that have intrinsically high and low rates of sequence variation. We show that the primary determinant of these patterns is shared genealogical history. Only a fraction of the variation (at most 25%) is due to the local mutation rate. By measuring the average distance over which genealogical histories are typically preserved, these data provide the first genome-wide estimate of the average extent of correlation among variants (linkage disequilibrium). The results are best explained by extreme variability in the recombination rate at a fine scale, and provide the first empirical evidence that such recombination 'hot spots' are a general feature of the human genome and have a principal role in shaping genetic variation in the human population. 相似文献
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潘江 《科技情报开发与经济》2004,14(6):9-10
引入研究型大学及其图书馆的定义,阐述了研究型大学图书馆进行人力资源管理的重要意义。进而提出了研究型大学图书馆人力资源管理的策略,包括改变人力资源管理理念,建立以人为本的人才管理机制,注重人才的使用和培养,充分调动馆员的积极性等。 相似文献
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庞晓青 《科技情报开发与经济》2004,14(6):250-251
人才是提高综合国力的关键要素。为用好人才,一是要辨证地把握好识别人才、起用人才的标准,既要选拔出德才兼备的人才,又不可求全责备;二是用人要讲究方法。做到公平竞争、择优录用、知人善用,同时鼓励人才合理流动;三是用人要遵循讲正气、讲民主、讲大度的原则,大胆使用人才。 相似文献
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