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排序方式: 共有179条查询结果,搜索用时 15 毫秒
91.
A cluster of phosphorylation sites on the cyclic AMP-regulated nuclear factor CREB predicted by its sequence 总被引:130,自引:0,他引:130
G A Gonzalez K K Yamamoto W H Fischer D Karr P Menzel W Biggs W W Vale M R Montminy 《Nature》1989,337(6209):749-752
92.
Reduced levels of hsp90 compromise steroid receptor action in vivo 总被引:71,自引:0,他引:71
D Picard B Khursheed M J Garabedian M G Fortin S Lindquist K R Yamamoto 《Nature》1990,348(6297):166-168
93.
94.
A role of selenium against methylmercury toxicity. 总被引:1,自引:0,他引:1
95.
96.
Expression of functional acetylcholine receptor from cloned cDNAs 总被引:40,自引:0,他引:40
M Mishina T Kurosaki T Tobimatsu Y Morimoto M Noda T Yamamoto M Terao J Lindstrom T Takahashi M Kuno 《Nature》1984,307(5952):604-608
The cloned cDNAs encoding the four subunits of the Torpedo californica acetylcholine receptor, each carried by a simian virus 40 vector, direct the synthesis of the functional receptor in a combined expression system consisting of COS monkey cells and Xenopus oocytes. Our results suggest that all four subunits are required to elicit a normal nicotinic response to acetylcholine, whereas only the alpha-subunit is indispensable for alpha-bungarotoxin binding activity. 相似文献
97.
98.
Kuma A Hatano M Matsui M Yamamoto A Nakaya H Yoshimori T Ohsumi Y Tokuhisa T Mizushima N 《Nature》2004,432(7020):1032-1036
At birth the trans-placental nutrient supply is suddenly interrupted, and neonates face severe starvation until supply can be restored through milk nutrients. Here, we show that neonates adapt to this adverse circumstance by inducing autophagy. Autophagy is the primary means for the degradation of cytoplasmic constituents within lysosomes. The level of autophagy in mice remains low during embryogenesis; however, autophagy is immediately upregulated in various tissues after birth and is maintained at high levels for 3-12 h before returning to basal levels within 1-2 days. Mice deficient for Atg5, which is essential for autophagosome formation, appear almost normal at birth but die within 1 day of delivery. The survival time of starved Atg5-deficient neonates (approximately 12 h) is much shorter than that of wild-type mice (approximately 21 h) but can be prolonged by forced milk feeding. Atg5-deficient neonates exhibit reduced amino acid concentrations in plasma and tissues, and display signs of energy depletion. These results suggest that the production of amino acids by autophagic degradation of 'self' proteins, which allows for the maintenance of energy homeostasis, is important for survival during neonatal starvation. 相似文献
99.
Natural examples of olivine lattice preferred orientation patterns with a flow-normal a-axis maximum
Tectonic plate motion is thought to cause solid-state plastic flow within the underlying upper mantle and accordingly lead to the development of a lattice preferred orientation of the constituent olivine crystals. The mechanical anisotropy that results from such preferred orientation typically produces a direction of maximum seismic wave velocity parallel to the plate motion direction. This has been explained by the existence of an olivine preferred orientation with an 'a-axis' maximum parallel to the induced mantle flow direction. In subduction zones, however, the olivine a axes have been inferred to be arranged roughly perpendicular to plate motion, which has usually been ascribed to localized complex mantle flow patterns. Recent experimental work suggests an alternative explanation: under conditions of high water activity, a 'B-type' olivine preferred orientation may form, with the a-axis maximum perpendicular to the flow direction. Natural examples of such B-type preferred orientation are, however, almost entirely unknown. Here we document widespread B-type olivine preferred orientation patterns from a subduction-type metamorphic belt in southwest Japan and show that these patterns developed in the presence of water. Our discovery implies that mantle flow above subduction zones may be much simpler than has generally been thought. 相似文献
100.
Macular corneal dystrophy type I and type II are caused by distinct mutations in a new sulphotransferase gene 总被引:8,自引:0,他引:8