Effects of several preoperative medications on fat cell lipolysis, and activity of adipose tissue cyclic AMP phosphodiesterase.

Effects were examined of atropine, diazepam, pethidene, promethazine, scopolamine, omnopon and papaverine on basal and noradrenaline-stimulated lipolysis in rat isolated fat cells and on rat adipose tissue cyclic AMP phosphodiesterase activity. Papaverine at high concentration (1 mM) inhibited both basal and hormone-stimulated lipolysis, whereas diazepam enhanced basal lipolysis. At a 'clinical dose', omnopon increased both basal and noradrenaline-stimulated lipolysis. Adipose tissue cAMP phosphodiesterase activity was strongly inhibited by 1 mM diazepam, papaverine, promethazine and omnopon (280 microgram ml-1). Lack of enhancement of lipolysis by the established cAMP phosphodiesterase antagonist papaverine, is compatible with simultaneous inhibition also of adipose adenyl cyclase. Diazepam-stimulated lipolysis is compatible with its phosphodiesterase inhibitory activity. It is proposed that papaverine-containing omnopon may offer some survival advantages during surgical stress by facilitating a caloric supply.     

Effect of insulin on immunological phagocytosis by macrophages.

It was shown that, in physiological concentrations, insulin enhances, in vitro, the immunological phagocytosis of sensitized sheep erythrocytes by cultured mouse peritoneal macrophages. Insulin seems to stimulate macrophage phagocytosis as a cholinomimetic agonist by increasing the intracellular levels of cyclic GMP.     

Isoprotenerol induction of pineal serotonin N-acetyltransferase in normotensive and spontaneously hypertensive rats

Zusammenfassung Verabreichung von Isoprotenerol, eines -adrenergen Agonisten, induziert einen signifikant höheren Anstieg der Aktivität der Serotonin-N-Acetyltransferase in der Epiphyse von spontan hypertensiven, im Vergleich mit normotensiven, Rattenmännchen. Derselbe Unterschied wurde auch bei Weibchen beobachtet, jedoch liegen die Aktivitätswerte bei spontan hypertensiven Männchen allgemein höher. Die durch Isoprotenerol erhöhte Induktion der Serotonin-N-Acetyltransferase erzeugt hinsichtlich der Catecholamine in den Pinealozyten von spontan hypertensiven Ratten eine veränderte Reaktivität der Achse -Rezeptor-Adenylzyklasesystem-Serotonin-N-Acetyl transferase.     

Early investigations on the effect of methyl mercuric chloride upon DMN-acute hepatotoxicity

Summary Acute toxicity induced by DMN was partially prevented by previously administering methyl mercuric chloride (MMC), a chemical inhibitor of the drug metabolizing enzyme system (DMES). We have studied the early changes occurring during the course of DMN-intoxication, namely disaggregation of polysomal profiles and necrosis, evaluated morphologically and by the release of S-GPT.This work was supported by Consiglio Nazionale delle Ricerche, Roma, Italy.     

Serum enzyme activities in the African elephant (Loxodonta africana)

Summary The serum activities of aspartate aminotransferase, alanine aminotransferase, -hydroxybutyrate dehydrogenase and creatine phosphokinase have been measured in the African elephant. In general, the values were broadly comparable with those of man except that alanine aminotransferase was much lower and creatine phosphokinase higher. No variation due to age, sex, season or location was observed.     

Effects of physalaemin, a vaso-active peptide from amphibian skin, on the excitability of an identifiable molluscan giant neurone of Achatina fulica Férussac.

We examined effects of several vasoactive peptides (substance P, physalaemin, neurotensin, bradykinin, angiotensin etc.) on the excitability of molluscan giant neurones identified in the subesophageal ganglia of Achatina fulica Férussac. Of these peptides, only physalaemin showed a remarkable excitatory effect on a giant tonically autoactive neurone.     

Pyrogen fever in rabbits pretreated with p-chlorophenylalanine or 5, 6-dihydroxytryptamine.

The hyperthermic effect of a bacterial pyrogen has been studied in rabbits pretreated or not with p-chlorophenylalanine or 5, 6-dihydroxytryptamine. The results obtained indicate that a selective reduction of cerebral 5-hydroxytryptamine levels by these drugs do not significantly affect pyrogen hypertermia.     

基于Logistic映射的图像保密通信

将Logistic映射产生的混沌序列作为载波，利用序列具有的良好相关特性，提出了一种图像保密通信方案。计算机仿真结果表明，只要收发双方使用相同的初值条件，即使在有一定噪声的情况下也能正确地进行图像传输，而初值的微小差异将导致通信失败，表明混沌序列用于保密通信具有很高的安全性能，同时方案具有很强的抗干扰能力。对图像恢复质量进行了评估，并给出了误比特率与码片长度的经验公式。     

火箭飞行数据的两种滤波方法对比

传统的火箭飞行数据处理方法是使用α-β-γ数字滤皮离线处理，对飞行数据采样信号的第1点、第2点不进行滤波估值，第3点开始逐个进行估值、预测、校正。该方法需要消耗大量的时间，并且滤波后信号的残留噪声仍然较多。针对此问题，经过大量的数值实验和理论分析，发现用小波方法实时处理火箭飞行数据效果较好，比较两种结果，证明无论是滤波后信号的残留噪声还是消耗的时间上小波方法都优于α-β-γ滤波，且实现了数据的实时处理功能，应用前景好。     

组合预测模型的回归分析方法

给出求解组合预测权系数的回归分析方法，文章首先给出了基于最小二乘和最小一乘准则的线性回归组合预测模型，然后应用最小二乘原理得到权系数最小二乘估计值。由于最小一乘准则下，目标函数不可微，传统的优化规则方法无法求解，故文中提出用基于最小二乘的逐步变权方法进行求解。同时，还给出了百分误差绝对值最小为目标的组合预测模型及权系数求解方法。通过实例分析，表明组合预测模型的预测精度很高，回归效果很显著。