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12.
The French Ministry of Health, acting on the advice of its scientific council, has halted clinical trials of interferon in cancer patients after four out of eleven recipients died of myocardial infarctions. Trials are expected to resume after the domestically produced drug stock is repurified and successfully retested. It has been suggested that council oversight should be extended to imported interferon and other experimental drugs which are now being used in human trials without the Ministry's control or knowledge. 相似文献
13.
Robert Sollis 《Journal of forecasting》2005,24(3):221-231
Tests of forecast encompassing are used to evaluate one‐step‐ahead forecasts of S&P Composite index returns and volatility. It is found that forecasts over the 1990s made from models that include macroeconomic variables tend to be encompassed by those made from a benchmark model which does not include macroeconomic variables. However, macroeconomic variables are found to add significant information to forecasts of returns and volatility over the 1970s. Often in empirical research on forecasting stock index returns and volatility, in‐sample information criteria are used to rank potential forecasting models. Here, none of the forecasting models for the 1970s that include macroeconomic variables are, on the basis of information criteria, preferred to the relevant benchmark specification. Thus, had investors used information criteria to choose between the models used for forecasting over the 1970s considered in this paper, the predictability that tests of encompassing reveal would not have been exploited. Copyright © 2005 John Wiley & Sons, Ltd. 相似文献
14.
Gituru Wahiti Robe rt Wang Qing |feng Wang Yong Guo You |hao Colleg e of Life Sciences Wuhan University Wuhan Hubei China 《武汉大学学报:自然科学英文版》2003,8(1)
0 IntroductionAlismataceaeisacosmopolitanfamilythatconsistsof 11generaandapproximately 95species[1] .Allthespeciesinthisfamilyareaquaticorsemi aquaticwiththemajorityoccurringintheNewWorld .ThegenusCaldesiaisrestrictedtotheOldWorldfromAfricaandMadagascarandS… 相似文献
15.
Pang Xin-an Wang Qing-fengf Gituru W. Robert Liu Hong Yang Xiao-lin Liu Xing 《武汉大学学报:自然科学英文版》2003,8(2):455-458
Isoetes sinensis Palmer (Isoetaceae) is an aquatic or amphibious plant that is critically endangered in China. Previous studies have revealed
the crassulacean acid metabolism (CAM)-like photosynthetic pathway occurs commonly in submerged leaves in genusIsoetes. Water chemistry parameters and the titratable acidity content of the plant extract were measured from samples obtained in
the early morning (7∶00) and late afternoon (15∶00) from twoI. sinensis populations in China. One population occurs in the eulittoral zone of a freshwater tidal river at low elevation (134 m) and
another occurs in a densely vegetated, high elevation (1 100 m) alpine shallow pool. Significant differences in pH and titratable
acidity of the plant extract were detected between the morning and afternoon samples. These changes are associated with diurnal
changes in water chemistry. Our results provide the first evidence for the existence of the CAM pathway in the East Asian
endemicIsoetes sinensis Palmer. The magnitude of fluctuations in the titratable acidity of the plant extract may be correlated with the severe carbon
limitation imposed on the plants by its aquatic habitat.
Foundation item: Supported by the State Key Basic Research and Development Plan (G2000046805)
Biography:Pang Xin-an (1974-), male, Master candidate, research direction: conservation biology. 相似文献
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17.
Stephanie M. Robert Harald Sontheimer 《Cellular and molecular life sciences : CMLS》2014,71(10):1839-1854
Malignant gliomas are relentless tumors that offer a dismal clinical prognosis. They develop many biological advantages that allow them to grow and survive in the unique environment of the brain. The glutamate transporters system x c ? and excitatory amino acid transporters (EAAT) are emerging as key players in the biology and malignancy of these tumors. Gliomas manipulate glutamate transporter expression and function to alter glutamate homeostasis in the brain, which supports their own growth, invasion, and survival. As a consequence, malignant cells are able to quickly destroy and invade surrounding normal brain. Recent findings are painting a larger picture of these transporters in glioma biology, and as such are providing opportunities for clinical intervention for patients. This review will detail the current understanding of glutamate transporters in the biology of malignant gliomas and highlight some of the unique aspects of these tumors that make them so devastating and difficult to treat. 相似文献
18.
Studies in several areas in Arizona and New Mexico show that dwarf mistletoe ( Arceuthobium douglasii ) is rare in young Douglas-firs growing under infected overstories. Less than 5% of the Douglas-firs under 26 years old and less than 6% of those under 1.4m tall were infected in 77 mistletoe-infested stands. Both percent infection and mean dwarf mistletoe rating of young Douglas-firs increased as tree age, height, and stand dwarf mistletoe ratings increased. 相似文献
19.
Milne JC Lambert PD Schenk S Carney DP Smith JJ Gagne DJ Jin L Boss O Perni RB Vu CB Bemis JE Xie R Disch JS Ng PY Nunes JJ Lynch AV Yang H Galonek H Israelian K Choy W Iffland A Lavu S Medvedik O Sinclair DA Olefsky JM Jirousek MR Elliott PJ Westphal CH 《Nature》2007,450(7170):712-716
Calorie restriction extends lifespan and produces a metabolic profile desirable for treating diseases of ageing such as type 2 diabetes. SIRT1, an NAD+-dependent deacetylase, is a principal modulator of pathways downstream of calorie restriction that produce beneficial effects on glucose homeostasis and insulin sensitivity. Resveratrol, a polyphenolic SIRT1 activator, mimics the anti-ageing effects of calorie restriction in lower organisms and in mice fed a high-fat diet ameliorates insulin resistance, increases mitochondrial content, and prolongs survival. Here we describe the identification and characterization of small molecule activators of SIRT1 that are structurally unrelated to, and 1,000-fold more potent than, resveratrol. These compounds bind to the SIRT1 enzyme-peptide substrate complex at an allosteric site amino-terminal to the catalytic domain and lower the Michaelis constant for acetylated substrates. In diet-induced obese and genetically obese mice, these compounds improve insulin sensitivity, lower plasma glucose, and increase mitochondrial capacity. In Zucker fa/fa rats, hyperinsulinaemic-euglycaemic clamp studies demonstrate that SIRT1 activators improve whole-body glucose homeostasis and insulin sensitivity in adipose tissue, skeletal muscle and liver. Thus, SIRT1 activation is a promising new therapeutic approach for treating diseases of ageing such as type 2 diabetes. 相似文献
20.
Recognition of unmethylated histone H3 lysine 4 links BHC80 to LSD1-mediated gene repression 总被引:1,自引:0,他引:1
Lan F Collins RE De Cegli R Alpatov R Horton JR Shi X Gozani O Cheng X Shi Y 《Nature》2007,448(7154):718-722