排序方式: 共有35条查询结果,搜索用时 15 毫秒
31.
Hox protein mutation and macroevolution of the insect body plan 总被引:23,自引:0,他引:23
32.
M. J. Carver Joy D. Marks Nadine Roesky 《Cellular and molecular life sciences : CMLS》1961,17(7):315-316
Résumé La thiopérazine, qui est un derivé de la famille de la phénothiazine, a le pouvour d'inhibition sur l'activité du glucose-6-phosphate déhydrogénase et du 6-phosphogluconate déhydrogénase dans les globules rouges. Ce pouvoir est modifié si on ajoute du TPN dans le système enzymatique. Le degré de cette modification correspond à la dose de TPN employée.
Supported by the Nebraska Fund for Psychiatric Research. 相似文献
Supported by the Nebraska Fund for Psychiatric Research. 相似文献
33.
Laguette N Sobhian B Casartelli N Ringeard M Chable-Bessia C Ségéral E Yatim A Emiliani S Schwartz O Benkirane M 《Nature》2011,474(7353):654-657
The primate lentivirus auxiliary protein Vpx counteracts an unknown restriction factor that renders human dendritic and myeloid cells largely refractory to HIV-1 infection. Here we identify SAMHD1 as this restriction factor. SAMHD1 is a protein involved in Aicardi-Goutières syndrome, a genetic encephalopathy with symptoms mimicking congenital viral infection, that has been proposed to act as a negative regulator of the interferon response. We show that Vpx induces proteasomal degradation of SAMHD1. Silencing of SAMHD1 in non-permissive cell lines alleviates HIV-1 restriction and is associated with a significant accumulation of viral DNA in infected cells. Concurrently, overexpression of SAMHD1 in sensitive cells inhibits HIV-1 infection. The putative phosphohydrolase activity of SAMHD1 is probably required for HIV-1 restriction. Vpx-mediated relief of restriction is abolished in SAMHD1-negative cells. Finally, silencing of SAMHD1 markedly increases the susceptibility of monocytic-derived dendritic cells to infection. Our results demonstrate that SAMHD1 is an antiretroviral protein expressed in cells of the myeloid lineage that inhibits an early step of the viral life cycle. 相似文献
34.
Kraemer N Issa L Hauck SC Mani S Ninnemann O Kaindl AM 《Cellular and molecular life sciences : CMLS》2011,68(10):1719-1736
Cyclin dependent kinase 5 regulatory subunit-associated protein 2 (CDK5RAP2) has gained attention in the last years following
the discovery, in 2005, that recessive mutations cause primary autosomal recessive microcephaly. This disease is seen as an
isolated developmental defect of the brain, particularly of the cerebral cortex, and was thus historically also referred to
as microcephalia vera. Unraveling the pathomechanisms leading to this human disease is fascinating scientists because it can convey insight into
basic mechanisms of physiologic brain development (particularly of cortex formation). It also finds itself in the spotlight
because of its implication in trends in mammalian evolution with a massive increase in the size of the cerebral cortex in
primates. Here, we provide a timely overview of the current knowledge on the function of CDK5RAP2 and mechanisms that might
lead to disease in humans when the function of this protein is disturbed. 相似文献
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