The Relationship of ‘Systems Thinking’ to Action Research

This article investigates the relationship of systems thinking to action research by reviewing the main developments in systems thinking and relating these to action research. There are two main lines of thought in systems thinking that lead to wholly different conceptions about action research. The first (systems thinking) advocates thinking about real social systems that it assumes exist in the world. The second (systemic thinking) supposes only that the social construction of the world is systemic. Greater emphasis is placed on systemic thinking consistent with its greater importance to contemporary action research. The article concludes that systemic thinking when taken to its practical conclusion from a critical perspective offers to action research a somewhat unique liberating praxis. Concern that any liberating praxis could remain hollow is addressed through a certain kind of ‘spiritual’ awareness that is suggested by wholeness.     

Possible Implications of the Quantum Theory of Gravity: An Introduction to the Meduso-Anthropic Principle

If we assume that the constants of nature fluctuate near the singularity when a black hole forms (assuming, also, that physical black holes really do form singularities) then a process of evolution of universes becomes possible. We explore the implications of such a process for the origin of life, interstellar travel, and the human future.     

B7-H6/NKp30 interaction: a mechanism of alerting NK cells against tumors

Natural killer (NK) cells are lymphocytes of the innate immune system that sense target cells through a panel of activating and inhibitory receptors. Together with NKG2D, the natural cytotoxicity receptors (NCRs) are major activating receptors involved in tumor cell detection. Although numerous NKG2D ligands have been identified, characterization of the molecules interacting with the NCRs is still incomplete. The identification of B7-H6 as a counter structure of the NCR NKp30 shed light on the molecular basis of NK cell immunosurveillance. We review here the current knowledge on NKp30 and B7-H6, and we discuss their potential role in anti-tumor immunity.     

BMP2 activity, although dispensable for bone formation, is required for the initiation of fracture healing

Adult bones have a notable regenerative capacity. Over 40 years ago, an intrinsic activity capable of initiating this reparative response was found to reside within bone itself, and the term bone morphogenetic protein (BMP) was coined to describe the molecules responsible for it. A family of BMP proteins was subsequently identified, but no individual BMP has been shown to be the initiator of the endogenous bone repair response. Here we demonstrate that BMP2 is a necessary component of the signaling cascade that governs fracture repair. Mice lacking the ability to produce BMP2 in their limb bones have spontaneous fractures that do not resolve with time. In fact, in bones lacking BMP2, the earliest steps of fracture healing seem to be blocked. Although other osteogenic stimuli are still present in the limb skeleton of BMP2-deficient mice, they cannot compensate for the absence of BMP2. Collectively, our results identify BMP2 as an endogenous mediator necessary for fracture repair.     

澳大利亚麦龙虾触角腺组织学的初步研究

本文首次报道了以组织学手段对澳大利亚淡水螯虾-麦龙虾的触角腺进行研究的结果。根据组织学(?)征麦龙虾的触角腺可分为三个部分,它们依次为:端囊,迷路和肾管。端囊部分的细胞呈柱状,细胞核位于基部或中部。迷路部分的细胞呈短柱状,顶端有刷状缘,核位于基部或亚中部。肾管部分的细胞扁平,核很大偏向顶端,占据了细胞的大部分空间。在迷路和肾管部分没有明显的亚区的分别。     

Prediction of central nervous system embryonal tumour outcome based on gene expression.

Embryonal tumours of the central nervous system (CNS) represent a heterogeneous group of tumours about which little is known biologically, and whose diagnosis, on the basis of morphologic appearance alone, is controversial. Medulloblastomas, for example, are the most common malignant brain tumour of childhood, but their pathogenesis is unknown, their relationship to other embryonal CNS tumours is debated, and patients' response to therapy is difficult to predict. We approached these problems by developing a classification system based on DNA microarray gene expression data derived from 99 patient samples. Here we demonstrate that medulloblastomas are molecularly distinct from other brain tumours including primitive neuroectodermal tumours (PNETs), atypical teratoid/rhabdoid tumours (AT/RTs) and malignant gliomas. Previously unrecognized evidence supporting the derivation of medulloblastomas from cerebellar granule cells through activation of the Sonic Hedgehog (SHH) pathway was also revealed. We show further that the clinical outcome of children with medulloblastomas is highly predictable on the basis of the gene expression profiles of their tumours at diagnosis.     

Bibliography and subject index of the prairie skink, Eumeces septentrionalis (Baird) (Sauria: Scincindae)

The prairie skink, Eumeces septentrionalis , is a small, semifossorial lizard inhabiting the tall-grass prairies and savannas of the central lowland province region of North America. This study provides an extensive bibliography and subject index as a tool for current and future workers studying E. septentrionalis and related species.     

Nest-site selection by Sage Thrashers in southeastern Idaho

Nest sites selected by Sage Thrashers ( Oreoscoptes montanus ) in southeastern Idaho were characterized and compared with available habitat. Microhabitats within 5 m of nests had taller and more aggregated shrubs and less bare ground than the study area in general. Big sagebrush ( Artemisia tridentata wyomingensis ) plants used for nesting were taller than average ,available shrubs, had greater foliage density, were more often living, and more frequently had branches and foliage within 30 cm of the ground. Nest placement was specific with respect to relative nest height and distance from the top and perimeter of the support shrub. Sage Thrashers disproportionately used easterly exposures and underused westerly exposures for their nests.     

Observations on Double-crested Cormorants ( Phalacrocorax auritus ) at sportfishing waters in southwestern Utah

Counts of Double-crested Cormorants ( Phalacrocorax auritus ) were made at 13 reservoirs and lakes in southwestern Utah during 1989-91 to determine current abundance of that species. Food habits of cormorants were studied at three of the reservoirs in 1989. Data were also collected on trout abundance during standardized gill-netting to make comparisons between cormorant numbers and trout abundance. Cormorants were observed at all waters studied except one and were generally most numerous during the spring as they migrated through the area. Estimated cormorant abundance ranged from 0 to 34 bird-days per ha and was highest at the larger, lower-elevation reservoirs. Cormorants were summer residents at several of the larger reservoirs and nested successfully at Piute Reservoir. Trout accounted for 24-81% of the diet of cormorants, with Utah chubs constituting most of the remainder of the diet. Estimates of the annual consumption of fish by cormorants ranged from 0 to 15.8 kg per ha. The index of trout abundance was inversely related to cormorant abundance ( P < .01) at the waters studied. Cormorants apparently have increased in numbers and extended their range in southwestern Utah during the past decade. This change may be the result of factors that have led to similar changes throughout North America as well as some factors unique to Utah. Methods to mitigate the impact of predation by piscivorous birds of sportfisheries are discussed. The Utah Division of Wildlife Resources has initiated a new management plan at Minersville Reservoir that incorporates piscivorous birds into sportfish management at that reservoir.