排序方式: 共有114条查询结果,搜索用时 133 毫秒
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The PIN auxin efflux facilitator network controls growth and patterning in Arabidopsis roots 总被引:3,自引:0,他引:3
Blilou I Xu J Wildwater M Willemsen V Paponov I Friml J Heidstra R Aida M Palme K Scheres B 《Nature》2005,433(7021):39-44
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Structure of the inositol 1,4,5-trisphosphate receptor binding core in complex with its ligand 总被引:8,自引:0,他引:8
Bosanac I Alattia JR Mal TK Chan J Talarico S Tong FK Tong KI Yoshikawa F Furuichi T Iwai M Michikawa T Mikoshiba K Ikura M 《Nature》2002,420(6916):696-700
In a variety of cells, the Ca2+ signalling process is mediated by the endoplasmic-reticulum-membrane-associated Ca2+ release channel, inositol 1,4,5-trisphosphate (InsP3) receptor (InsP3R). Being ubiquitous and present in organisms ranging from humans to Caenorhabditis elegans, InsP3R has a vital role in the control of cellular and physiological processes as diverse as cell division, cell proliferation, apoptosis, fertilization, development, behaviour, memory and learning. Mouse type I InsP3R (InsP3R1), found in high abundance in cerebellar Purkinje cells, is a polypeptide with three major functionally distinct regions: the amino-terminal InsP3-binding region, the central modulatory region and the carboxy-terminal channel region. Here we present a 2.2-A crystal structure of the InsP3-binding core of mouse InsP3R1 in complex with InsP3. The asymmetric, boomerang-like structure consists of an N-terminal beta-trefoil domain and a C-terminal alpha-helical domain containing an 'armadillo repeat'-like fold. The cleft formed by the two domains exposes a cluster of arginine and lysine residues that coordinate the three phosphoryl groups of InsP3. Putative Ca2+-binding sites are identified in two separate locations within the InsP3-binding core. 相似文献
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I. Nikolov V. Pavlov I. Minkov D. Damjanov 《Cellular and molecular life sciences : CMLS》1990,46(7):765-767
Summary An amine oxidase was purified 447-fold from soybean seedlings and some of its properties were investigated. The molecular weight of the enzyme was estimated to be 25,000. It was most active towards putrescine, followed by spermidine and spermine. Km-values for these substrates were relatively close. The enzyme was strongly inhibited by carbonyl reagents, such as semicarbazide and aminoguanidine. 相似文献
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Identification and analysis of functional elements in 1% of the human genome by the ENCODE pilot project 总被引:2,自引:0,他引:2
ENCODE Project Consortium Birney E Stamatoyannopoulos JA Dutta A Guigó R Gingeras TR Margulies EH Weng Z Snyder M Dermitzakis ET Thurman RE Kuehn MS Taylor CM Neph S Koch CM Asthana S Malhotra A Adzhubei I Greenbaum JA Andrews RM Flicek P Boyle PJ Cao H Carter NP Clelland GK Davis S Day N Dhami P Dillon SC Dorschner MO Fiegler H Giresi PG Goldy J Hawrylycz M Haydock A Humbert R James KD Johnson BE Johnson EM Frum TT Rosenzweig ER Karnani N Lee K Lefebvre GC Navas PA Neri F Parker SC Sabo PJ 《Nature》2007,447(7146):799-816
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Opposing LSD1 complexes function in developmental gene activation and repression programmes 总被引:4,自引:0,他引:4
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An isotropic (+U) and anisotropic [+(U-J)] corrected Density Functional Theory study for bulk hematite (α-Fe_2O_3) was carried out,and several competing terminations of its (0001) surface modeled via slabs of increasing thickness from twelve to thirty-six Fe-layers.In spite of small quantitative differences,the use of either U or (U-J)corrections showed not to qualitatively affect the results of the simulations both for bulkα-Fe_2O_3 and the lowestenergyα-Fe_2O_3(0001) surface studied,regardless of the thickness of the slab used.The energy favored antiferromagnetic ordering of bulkα-Fe_2O_3 was preserved in the relaxed slabs,with the largest surface-induced effects limited to the outermost three Fe-layers in the slabs.Mixed O-and Fe-terminations were found to be energetically favored and insulating.Conversely,fully O-or Fe-terminated surfaces were calculated to be energetically disfavored and metallic.Finally,the role of Fe-or O-termination for the semiconducting or metallic nature as well as absolute band alignment ofα-Fe_2O_3 (0001) surfaces was analyzed and discussed with respect to the challenges in enhancing the activity ofα-Fe_2O_3 samples as photo-electrode for water splitting. 相似文献
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