Gould, Hull, and the Individuation of Scientific Theories

When is conceptual change so significant that we should talk about a new theory, not a new version of the same theory? We address this problem here, starting from Gould’s discussion of the individuation of the Darwinian theory. He locates his position between two extremes: ‘minimalist’—a theory should be individuated merely by its insertion in a historical lineage—and ‘maximalist’—exhaustive lists of necessary and sufficient conditions are required for individuation. He imputes the minimalist position to Hull and attempts a reductio: this position leads us to give the same ‘name’ to contradictory theories. Gould’s ‘structuralist’ position requires both ‘conceptual continuity’ and descent for individuation. Hull’s attempt to assimilate into his general selectionist framework Kuhn’s notion of ‘exemplar’ and the ‘semantic’ view of the structure of scientific theories can be used to counter Gould’s reductio, and also to integrate structuralist and population thinking about conceptual change.     

Dopamine-beta-hydroxylase activity in adrenal gland and spleen of rats after fasting and cold exposure

Summary Fasting (48 h) results in dopamine-beta-hydroxylase (DBH) release both in adrenal gland and spleen, suggestive of an increase in the activity of these organs. Cold exposure (48 h) produces a dissociation of the, sympathoadrenal response. When both stimuli are simultaneously employed, the DBH response suggests the preponderance of the response to fasting. Plasma DBH is decreased in all groups studied, this could be due to its half-life and the splenic DBH depletion.This work was supported by a grant of Fondo de Investigaciones Sanitarias de la Seguridad Social, No. 83/0905.     

Allozyme polymorphism and linkage disequilibrium ofAdh and α-Gpdh loci in wine cellar and field populations ofDrosophila melanogaster

Summary Over three years, theAdh and -Gpdh loci have been studied in two cellar populations ofDrosophila melanogaster and in two field populations which were each near to one of the cellars. Analyses of gene frequencies indicate that the divergence among subpopulations is greater in theAdh locus than in the -Gpdh locus. Selection for or againstAdh ^S allele acting on theIn(2L)t inversion influences of the -Gpdh alleles. This phenomenon may contribute to explain the maintenance of theAdh and -Gpdh polymorphism and of theIn(2L)t inversion.     

A new method for obtaining blood from a small mammal without injuring the animal: use of Triatomid bugs

Summary By means of hungry Triatomid bugs, samples of blood (40–200l) can be obtained from small mammals, such as bats, without causing any harm to the animals. The blood can be extracted from the gaster of the bug immediately after the bug has finished sucking. The method was successfully used for measuring the energy budget by the doubly labeled water method, and for obtaining material for lymphocyte cultures, and may prove useful in other fields, too.M. Volleth is very much obliged to Prof. Dr R. A. Pfeiffer for giving her the opportunity to work at the Institute of Human Genetics.     

Identification and characterization of new functional truncated variants of somatostatin receptor subtype 5 in rodents

Somatostatin and cortistatin exert multiple biological actions through five receptors (sst1-5); however, not all their effects can be explained by activation of sst1-5. Indeed, we recently identified novel truncated but functional human sst5-variants, present in normal and tumoral tissues. In this study, we identified and characterized three novel truncated sst5 variants in mice and one in rats displaying different numbers of transmembrane-domains [TMD; sst5TMD4, sst5TMD2, sst5TMD1 (mouse-variants) and sst5TMD1 (rat-variant)]. These sst5 variants: (1) are functional to mediate ligand-selective-induced variations in [Ca²⁺]_i and cAMP despite being truncated; (2) display preferential intracellular distribution; (3) mostly share full-length sst5 tissue distribution, but exhibit unique differences; (4) are differentially regulated by changes in hormonal/metabolic environment in a tissue- (e.g., central vs. systemic) and ligand-dependent manner. Altogether, our results demonstrate the existence of new truncated sst5-variants with unique ligand-selective signaling properties, which could contribute to further understanding the complex, distinct pathophysiological roles of somatostatin and cortistatin.     

French historical epistemology: Discourse,concepts, and the norms of rationality

In recent years, analytic philosophers have begun to recognize the value of the French school of historical epistemology (as embodied by figures such as Jean Cavaillès, Gaston Bachelard, Georges Canguilhem, and Michel Foucault) for contemporary debates in the history and philosophy of science. This tradition, which some characterize as a ‘French’ approach to the philosophy of science, however, remains largely un-read by mainstream philosophers of science. This article offers an interpretation of this tradition, highlighting what the author takes to be its two central features: (i) its claim that scientific discourse is the object of epistemology and (ii) its claim that scientific concepts are the building blocks of scientific discourse.     

Detecting and Predicting Economic Accelerations,Recessions, and Normal Growth Periods in Real‐Time

The dichotomous characterization of the business cycle in recessions and expansions has been central in the literature over the last 50 years. However, there are various reasons to question the adequacy of this dichotomous, recession/expansion approach for our understanding of the business cycle dynamics, as well as for the prediction of future business cycle developments. In this context, the contribution of this paper to the literature is twofold. First, since a positive rate of growth at the level of economic activity can be considered as the normal scenario in modern economies due to both population and technological growth, it proposes a new non‐parametric algorithm for the detection and dating of economic acceleration periods, trend or normal growth periods, and economic recessions. Second, it uses an ordered probit framework for the estimation and forecasting of these three business cycle phases, applying an automatized model selection approach using monthly macroeconomic and financial data on the German economy. The empirical results show that this approach has superior out‐of‐sample properties under real‐time conditions compared to alternative probit models specified individually for the prediction of recessions and/or economic accelerations. Copyright © 2016 John Wiley & Sons, Ltd.     

Activity patterns and habitat use of pudu deer (Pudu puda) in a mountain forest of south-central Chile

The pudu (Pudu puda) is a small, endemic deer, and the only native ungulate found in Chilean and Argentinean temperate forests. Its ecology, including its double role as an herbivore and as a prey, is poorly known. Therefore, it is pressing to gain a better understanding of the pudu given that its habitat is being transformed rapidly by anthropogenic causes. On a coastal mountain range in south-central Chile, we conducted a habitat use study and examined the activity patterns of the pudu using camera traps. The study area was a large native forest patch, surrounded by commercial plantations which would not constitute a habitat for this deer. Using a sampling effort of 7559 camera days, we found that this deer was largely nocturnal with little activity during daytime. The pudu selected Araucaria forests, and avoided Nothofagus forests. These behaviours suggest that the pudu traded off habitat use patterns and activity time to avoid predation, mainly by puma which is the top predator in the rich local community of carnivores occurring in the latter habitat.     

Hydroxylation of demethoxy-Q6 constitutes a control point in yeast coenzyme Q6 biosynthesis

Coenzyme Q is a lipid molecule required for respiration and antioxidant protection. Q biosynthesis in Saccharomyces cerevisiae requires nine proteins (Coq1p–Coq9p). We demonstrate in this study that Q levels are modulated during growth by its conversion from demethoxy-Q (DMQ), a late intermediate. Similar conversion was produced when cells were subjected to oxidative stress conditions. Changes in Q₆/DMQ₆ ratio were accompanied by changes in COQ7 gene mRNA levels encoding the protein responsible for the DMQ hydroxylation, the penultimate step in Q biosynthesis pathway. Yeast coq null mutant failed to accumulate any Q late biosynthetic intermediate. However, in coq7 mutants the addition of exogenous Q produces the DMQ synthesis. Similar effect was produced by over-expressing ABC1/COQ8. These results support the existence of a biosynthetic complex that allows the DMQ₆ accumulation and suggest that Coq7p is a control point for the Q biosynthesis regulation in yeast. Electronic supplementary material  The online version of this article (doi:) contains supplementary material, which is available to authorized users. Received 04 September 2008; received after revision 22 October 2008; accepted 23 October 2008