二维圆柱层流绕流及其控制数值模拟

采用有限体积法求解二维N-S方程,通过改变时间、空间计算参数,对雷诺数100的二维圆柱非定常流场进行了数值模拟,将所得结果与实验数据以及已有的计算结果进行了对比.并对在尾部多个位置加入不同长度阻隔板控制流动的圆柱流场进行了考察.结果发现:在合适的位置放置阻隔板,可以有效抑制尾迹中涡脱落的形成.     

准噶尔盆地南缘吐谷鲁、安集海构造剖面平衡地质检验

吐谷鲁构造、安集海构造分别位于准噶尔盆地南缘第二排背斜带与第三排背斜带上 ,TGN- 961 5地震测线与 AGH- 1 5地震测线由南向北分别横穿吐谷鲁构造、安集海构造。通过对地震剖面的构造解释 ,运用平衡地质剖面的恢复法 ,对 TGN- 961 5地震测线与 AGH- 1 5地震测线变形剖面进行了平衡检验 ,其结果都在误差范围内 ,表明解释方案是合理的。通过变形剖面与复原剖面的对比 ,得出剖面缩短率分别为 1 8.3%与 7.0 3%。     

Drug release from a coated planar matrix with a super-saturation loading in the core I

A comprehensive model is proposed to accurately describe the kinetics of drug release from a coated matrix when drug loading in the core is above its saturation level. The general solutions are obtained in dimensionless form by Laplace transform, from which special cases have been derived and the results have been discussed in different variables. According to the derived equations, the concentration profiles in the core and coating were computed and il¬lustrated for various diffusivity ratios and thickness ratios.     

实验的可重复性研究——新实验主义与科学知识社会学比较

传统的科学观认为实验的可重复性是自明和不可或缺的,可重复的原则是科学事实成立的重要判据,是科学确定性、普遍性的奠基石.SSK和新实验主义都对这一原则进行了深入的分析,指出了传统观点在此问题上的缺陷.尽管如此,SSK和新实验主义由于关注点、研究方法和认识论等方面的不同,各自的研究思路和结论也有差异.本文主要探讨并比较了两者对实验可重复性的相关研究,最后对如何看待实验可重复性提出一点见解.     

Reactive scheduling of multiple EOSs under cloud uncertainties: model and algorithms

Most earth observation satellites(EOSs)are low-orbit satellites equipped with optical sensors that cannot see through clouds.Hence,cloud coverage,high dynamics,and cloud uncertainties are important issues in the scheduling of EOSs.The proactive-reactive scheduling framework has been proven to be effective and efficient for the uncertain scheduling problem and has been extensively employed.Numerous studies have been conducted on methods for the proactive scheduling of EOSs,including expectation,chance-constrained,and robust optimization models and the relevant solution algorithms.This study focuses on the reactive scheduling of EOSs under cloud uncertainties.First,using an example,we describe the reactive scheduling problem in detail,clarifying its significance and key issues.Considering the two key objectives of observation profits and scheduling stability,we construct a multi-objective optimization mathematical model.Then,we obtain the possible disruptions of EOS scheduling during execution under cloud uncertainties,adopting an event-driven policy for the reactive scheduling.For the different disruptions,different reactive scheduling algorithms are designed.Finally,numerous simulation experiments are conducted to verify the feasibility and effectiveness of the proposed reactive scheduling algorithms.The experimental results show that the reactive scheduling algorithms can both improve observation profits and reduce system perturbations.     

Common variants at TRAF3IP2 are associated with susceptibility to psoriatic arthritis and psoriasis

Psoriatic arthritis (PsA) is an inflammatory joint disease that is distinct from other chronic arthritides and which is frequently accompanied by psoriasis vulgaris (PsV) and seronegativity for rheumatoid factor. We conducted a genome-wide association study in 609 German individuals with PsA (cases) and 990 controls with replication in 6 European cohorts including a total of 5,488 individuals. We replicated PsA associations at HLA-C and IL12B and identified a new association at TRAF3IP2 (rs13190932, P = 8.56 × 10?1?). TRAF3IP2 was also associated with PsV in a German cohort including 2,040 individuals (rs13190932, P = 1.95 × 10?3). Sequencing of the exons of TRAF3IP2 identified a coding variant (p.Asp10Asn, rs33980500) as the most significantly associated SNP (P = 1.13 × 10?2?, odds ratio = 1.95). Functional assays showed reduced binding of this TRAF3IP2 variant to TRAF6, suggesting altered modulation of immunoregulatory signals through altered TRAF interactions as a new and shared pathway for PsA and PsV.     

SLC2A9 influences uric acid concentrations with pronounced sex-specific effects

Serum uric acid concentrations are correlated with gout and clinical entities such as cardiovascular disease and diabetes. In the genome-wide association study KORA (Kooperative Gesundheitsforschung in der Region Augsburg) F3 500K (n = 1,644), the most significant SNPs associated with uric acid concentrations mapped within introns 4 and 6 of SLC2A9, a gene encoding a putative hexose transporter (effects: -0.23 to -0.36 mg/dl per copy of the minor allele). We replicated these findings in three independent samples from Germany (KORA S4 and SHIP (Study of Health in Pomerania)) and Austria (SAPHIR; Salzburg Atherosclerosis Prevention Program in Subjects at High Individual Risk), with P values ranging from 1.2 x 10(-8) to 1.0 x 10(-32). Analysis of whole blood RNA expression profiles from a KORA F3 500K subgroup (n = 117) showed a significant association between the SLC2A9 isoform 2 and urate concentrations. The SLC2A9 genotypes also showed significant association with self-reported gout. The proportion of the variance of serum uric acid concentrations explained by genotypes was about 1.2% in men and 6% in women, and the percentage accounted for by expression levels was 3.5% in men and 15% in women.     

基于智能虚拟环境的地铁站台仿真系统

实现了一个用于列车驾驶培训的地铁站台仿真系统.系统由一个可被感知的站台虚拟环境和虚拟乘客系统组成.站台环境由静态场景、动态场景两部分组成,可在用户控制下发生变化.虚拟乘客通过感知站台环境的变化做出行为判断与动作.乘客仿真模型采用分层结构,分别实现环境感知、决策、行为选择、动作实现与实时绘制.目前,该系统已用于地铁列车仿真器,成为培训司机站台操作的工具.     

基于HLA/RTI的联合仿真建模技术框架

针对复杂系统仿真建模中存在的分布式交互、协同性及动态性等问题,分别着重研究了HLA/RTI、人工生命MAS、DEVS等仿真建模技术及其相互间的联合策略,在HLA/RTI高层软件体系框架下,以人工生命MAS为系统基本单元建模,以DEVS为系统基础环境建模,并在此基础上,提出了一种联合仿真建模技术框架,给出了在军事后勤保障仿真建模中的应用实例.     

MYH9 is associated with nondiabetic end-stage renal disease in African Americans

As end-stage renal disease (ESRD) has a four times higher incidence in African Americans compared to European Americans, we hypothesized that susceptibility alleles for ESRD have a higher frequency in the West African than the European gene pool. We carried out a genome-wide admixture scan in 1,372 ESRD cases and 806 controls and found a highly significant association between excess African ancestry and nondiabetic ESRD (lod score = 5.70) but not diabetic ESRD (lod = 0.47) on chromosome 22q12. Each copy of the European ancestral allele conferred a relative risk of 0.50 (95% CI = 0.39-0.63) compared to African ancestry. Multiple common SNPs (allele frequencies ranging from 0.2 to 0.6) in the gene encoding nonmuscle myosin heavy chain type II isoform A (MYH9) were associated with two to four times greater risk of nondiabetic ESRD and accounted for a large proportion of the excess risk of ESRD observed in African compared to European Americans.