Phosphate mobilization from striated muscle following parathyroid hormone administration to thyroparathyroidectomized rats

Summary Parathyroid hormone administration to thyroparathyroidectomized rats resulted in a significant reduction in inorganic phosphate content of a variety of striated muscles. Most other organs were unaffected. Much of the extra urinary phosphate present after parathyroid hormone stimulation may be released from the muscles.Supported in part by a grant from the Marquette University Committee on Research.     

Intensification of amphetamine-induced excitation by methysergide,a serotonergic receptor blocker

Summary Methysergide, a serotonergic receptor blocker, was studied to determine its effects against d-amphetamine-induced excitation as measured by convulsions elicited by handling in mice. Significant intensification (p<0.01) of the action of d-amphetamine was observed in mice. These results indicate that reduction in serotonergic activity in the central nervous system enhances excitation induced by d-amphetamine.This work was supported by the Pharmaceutical Manufacturer Association Starter Grant, No. 5 S01 RR 05654-06 and the Air Force Office of Scientific Research Grant. The authors are grateful to Ben Wiggins, Michael Wallace, Maria Salazar, and Sanford Futterman for their technical assistance. The authors are also grateful to Dr Boris Tabakoff for supplying the formula of the CSF used in this experiment and we are indebted to San Antonio College for the use of their computer facilities. Dr Blum is a Career Teacher in drug addiction sponsored by NIDA, grant No. 1-T01-DA00290-01.     

Some observations on the Rohon-Beard cell perikaryon

Summary During the hatching period, the Rohon-Beard cells of Salmo gairdneri showed definite structural maturity of their perikarya, which is in contrast to the amphibian species investigated, where neuronal maturation of the Rohon-Beard cells is finished only in later — posthatching — developmental stages.     

Role of acoustic stress on the development of polyoma tumors in immunized golden hamsters]

An acoustic stress increases the metastatic spread of polyoma virus-induced tumors in syrian Hamsters. To try to elucidate the mechanism of this action, we studied the effect of stress on the protection afforded by the virus against tumour challenge. Exposure to ultrasonics during the immunization period markedly decreased the protective effect of the virus.     

Einwirkung einiger Carbonylreagentien auf das Virus der Maul- und Klauenseuche (MKS)

Summary The virus of foot and mouth disease is inactivated by hydroxylamine, hydrazine and semicarbazide. Such inactivated virus does not differ serologically from intact virus, and represents an interesting antigen for purposes of immunization.

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Herrn Dr.G. A. Moosbrugger, Leiter des Eidg. Vakzine-Instituts in Basel, danken wir, dass er uns die Durchführung dieser Untersuchungen ermöglicht hat.     

A propos du mode d'action de l'iproniazide,inhibiteur de la mono-amino-oxydase

Zusammenfassung Der Einfluss von Iproniazid auf das phosphorylase-aktivierende System kennzeichnet sich durch eine Erhöhung der Adrenalin- und eine Verminderung der Glucagon-Wirkung. Es ist möglich, dass die Katalyse der Ringbildung aus ATP in Gegenwart bestimmter Aminogruppen durch Iproniazid begünstigt wird.