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Enciso-Mora V Broderick P Ma Y Jarrett RF Hjalgrim H Hemminki K van den Berg A Olver B Lloyd A Dobbins SE Lightfoot T van Leeuwen FE Försti A Diepstra A Broeks A Vijayakrishnan J Shield L Lake A Montgomery D Roman E Engert A von Strandmann EP Reiners KS Nolte IM Smedby KE Adami HO Russell NS Glimelius B Hamilton-Dutoit S de Bruin M Ryder LP Molin D Sorensen KM Chang ET Taylor M Cooke R Hofstra R Westers H van Wezel T van Eijk R Ashworth A Rostgaard K Melbye M Swerdlow AJ Houlston RS 《Nature genetics》2010,42(12):1126-1130
To identify susceptibility loci for classical Hodgkin's lymphoma (cHL), we conducted a genome-wide association study of 589 individuals with cHL (cases) and 5,199 controls with validation in four independent samples totaling 2,057 cases and 3,416 controls. We identified three new susceptibility loci at 2p16.1 (rs1432295, REL, odds ratio (OR) = 1.22, combined P = 1.91 × 10(-8)), 8q24.21 (rs2019960, PVT1, OR = 1.33, combined P = 1.26 × 10(-13)) and 10p14 (rs501764, GATA3, OR = 1.25, combined P = 7.05 × 10(-8)). Furthermore, we confirmed the role of the major histocompatibility complex in disease etiology by revealing a strong human leukocyte antigen (HLA) association (rs6903608, OR = 1.70, combined P = 2.84 × 10(-50)). These data provide new insight into the pathogenesis of cHL. 相似文献