Identification of the familial cylindromatosis tumour-suppressor gene

Familial cylindromatosis is an autosomal dominant genetic predisposition to multiple tumours of the skin appendages. The susceptibility gene (CYLD) has previously been localized to chromosome 16q and has the genetic attributes of a tumour-suppressor gene (recessive oncogene). Here we have identified CYLD by detecting germline mutations in 21 cylindromatosis families and somatic mutations in 1 sporadic and 5 familial cylindromas. All mutations predict truncation or absence of the encoded protein. CYLD encodes three cytoskeletal-associated-protein-glycine-conserved (CAP-GLY) domains, which are found in proteins that coordinate the attachment of organelles to microtubules. CYLD also has sequence homology to the catalytic domain of ubiquitin carboxy-terminal hydrolases (UCH).     

Elevation of hepatic tyrosine 2-oxoglutarate aminotransferase in rats by 4-pentynoic acid,a hypoglycemic agent

Zusammenfassung 4-Pentinsäure, ein hypoglykämisches Mittel, vermehrte Leber-Tyrosinaminotransferase in intakten, nicht aber in adrenalektomierten Ratten.     

The structure of WI3, the first optically active biflavone of the amentoflavone series

Résumé Araucaria cookii donne les premières bisflavones optiquement actives de la série des amentoflavones. Une analyse complète des spectra de RNM des substances de cette série a été faite. Les déplacements méthoxyliques induits par le solvant s'ajoutent aux résultats de l'analyse de RNM et les confirment.     

The Molecule Pages database

The Alliance for Cellular Signaling (AfCS)-Nature Molecule Pages will be a comprehensive database of key facts about more than 3,000 proteins involved in cell signalling. Each entry will be created by invited experts and be peer-reviewed. Alongside the large-scale experiments being conducted by the AfCS scientists, the wealth of information contained in this database offers the potential of accelerating the pace of discovery in signal transduction research.     

Home-range size and overlap of sympatric male mule and white-tailed deer in Texas

Information about the ecology of sympatric male deer is limited, which may influence management strategies for these species. We estimated home-range and core-area sizes and overlap, and survival of sympatric male desert mule deer ( Odocoileus hemionus eremicus ) and white-tailed deer ( Odocoileus virginianus ) in west central Texas. We captured 18 males of each species, fitted them with radio-collars, and monitored them for mortality from 2000 through 2003. We calculated home ranges for 7 males of each species in 2001 and 2002. Home-range sizes of mule deer (8.8 km 2 ) and white-tailed deer (7.4 km 2 ) were similar. Interspecific home-range overlap was less common than intraspecific overlap. Mean annual survival was 0.76 (SE = 0.04) for mule deer and 0.80 (SE = 0.06) for white-tailed deer. The high degree of home-range overlap and similar survival between the 2 deer species suggest that management targeting only 1 species may be unfeasible.