Estimating the proportion of variation in susceptibility to schizophrenia captured by common SNPs

Schizophrenia is a complex disorder caused by both genetic and environmental factors. Using 9,087 affected individuals, 12,171 controls and 915,354 imputed SNPs from the Schizophrenia Psychiatric Genome-Wide Association Study (GWAS) Consortium (PGC-SCZ), we estimate that 23% (s.e. = 1%) of variation in liability to schizophrenia is captured by SNPs. We show that a substantial proportion of this variation must be the result of common causal variants, that the variance explained by each chromosome is linearly related to its length (r = 0.89, P = 2.6 × 10(-8)), that the genetic basis of schizophrenia is the same in males and females, and that a disproportionate proportion of variation is attributable to a set of 2,725 genes expressed in the central nervous system (CNS; P = 7.6 × 10(-8)). These results are consistent with a polygenic genetic architecture and imply more individual SNP associations will be detected for this disease as sample size increases.     

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The Interaction Betweena Reader and a Text in Reading Process —— the Application of Schemata Theory in Reading Two Poems

Ｆｏｒｃｅｎｔｕｒｉｅｓ，ｔｈｅｒｅｈａｓｂｅｅｎａｎｅｖｅｒｉｎｃｒｅａｓｉｎｇｉｎｔｅｒｅｓｔｉｎｔｈｅｎａｔｕｒｅｏｆｒｅａｄｉｎｇｐｒｏｃｅｓｓ，ａｎｄｍａｎｙｏｆｔｈｅｓｅａｔｔｅｍｐｔｓｔｏｄｅｓｃｒｉｂｅｔｈｅｐｒｏｃｅｓｓｈａｖｅｂｅｅｎｉｎｃｏｎｆｌｉｃｔｗｉｔｈｅａｃｈｏｔｈｅｒ，ｗｈｉｃｈｍａｋｅｓｕｓｒｅａｄｅｒｓｃｏｎ ｆｕｓｅｄｉｎｕｎｄｅｒｓｔａｎｄｉｎｇａｎｄａｐｐｒｅｃｉａｔｉｎｇａｔｅｘｔ，ｅｓｐｅ ｃｉａｌｌｙａｌｉｔｅｒａｒｙｏｎｅ．Ｔｒａｄｉｔｉｏｎａｌｌ…     

A NOTE ON THE PAPER “UNIFORM PERSISTENCE IN DISCRETE SEMIDYNAMICAL SYSTEM AND ITS APPLICATION”

1.IntroductionAsweknow,theresearchonthepersistenceofnonautonomousKolmogorovspeciessystems:isallalongaveryimportantsllbjectinthetheoryofmathematicalbiology.But,sofar,theworkonitisnotenough.ThemainresultsachievedarealmostconcernedwiththeLotka-Volterrasystems.Recently,in[l]theauthorshavehadahelpfultryonthestudyofuniformpersistenceoftwodimensionalperiodicKolmogorovsystem:Unfortunately,thereisamistakeintheproofofthemainTheorem3.3in[1].Themistakemakestheconclusionofthistheoremdoubtful.Asanimprov…     

40Cr钢离子注入后表面形态变化初探

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THE EFFECT OF ZnO ON BURNING OF PORTLAND CEMENT CLLNKER IN RAPID MEATING－UP BURNING

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酶法生产全脂加糖大豆炼乳

大豆含有丰富的蛋白质和较完全的氨基酸,是一种营养价值很高的农产品。如何充分利用大豆蛋白资源,拓宽大豆深加工领域,已引起国内外学者的重视。美国有人采用大豆分离蛋白和玉米淀粉生产甜炼乳,日本有人将大豆与食用油混合磨制大豆糊,国内有过把加糖豆乳浓缩制成豆炼乳的报道,但未见该类产品面市。本研究采用一种新方法——蛋白酶法生产大豆炼乳,取得了比较满意的结果。     

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