Feedback control strategy of longitudinal temperature and finished carbonization time for coke oven and its application

Based on the detailed analysis of the third coke oven in BaoSteel, a feedback control strategy of longitudinal temperature and finished carbonization time of coke ovens was proposed and it was applied to the third coke oven in BaoSteel. As a result, the ratio of the instance that the absolute deviation of the longitudinal temperature is within ±7°C and the finished carbonization time within ± 10 min is more than 80%, having acquired the patent saving effect of an energy consumption lowered by 2.92%. At the same time, it can provide an example for the same coke ovens inside and outside the nation.     

西藏措勤盆地晚中生代构造—岩相演化

措勤盆地的坟要形成、发育期为中生代。由于受南、北两条特提斯构造带的影响,盆地内东西向构造岩相分带比较明显,并与一定的沉积环境相对应,即由海相－三角洲相－滨滩相－台地相－陆相沉积。晚中生代措勤盆地的地层说明了分盆地的演化经历了从沉陷－稳定－隆起的构造旋回过程,从而反映了从裂谷－洋盆－残余海封闭及断陷盆地发育的９沉积历史。在盆地内,川巴－色林错地区发育了一套具有一定生油条件、富含有机质的残留海盆沉积,     

Cauchy问题概率解法收敛性

对于抛物型偏微分方程中的Ｃａｕｃｈｙ问题,本文给出了用Ｍｏｎｔｅ－Ｃａｒｌｏ方法计算出某布朗运动中ｔ时刻前之期望值的数值解法,并证明了此数值解的依概率收敛性。     

Advances in TiS2 for energy storage,electronic devices,and catalysis: A review

As the lightest family member of the transition metal disulfides(TMDs), TiS₂ has attracted more and more attention due to its large specific surface area, adjustable band gap, good visible light absorption, and good charge transport properties. In this review, the recent state-of-the-art advances in the syntheses and applications of TiS₂ in energy storage, electronic devices, and catalysis have been summarized. Firstly, according to the physical presentation of the TiS_...     

Natural tourmaline activated peracetic acid for efficient degradation of sulfadiazine: Reaction mechanisms and catalyst reusability

Peracetic acid(PAA) has received extensive attention in the water treatment due to its high oxidation potential and low toxicity of by-products. In this study, natural non-toxic mineral tourmaline(TM) was used to activate PAA to remove sulfadiazine(SDZ). The TM/PAA system could remove 92 % SDZ in 120 min. The radical analysis confirmed the co-existence of both free radical and non-free radical degradation pathways in the TM/PAA system,indicating that singlet oxygen(¹O₂) and...     

A genome-wide association study identifies two new lung cancer susceptibility loci at 13q12.12 and 22q12.2 in Han Chinese

Lung cancer is the leading cause of cancer-related deaths worldwide. To identify genetic factors that modify the risk of lung cancer in individuals of Chinese ancestry, we performed a genome-wide association scan in 5,408 subjects (2,331 individuals with lung cancer (cases) and 3,077 controls) followed by a two-stage validation among 12,722 subjects (6,313 cases and 6,409 controls). The combined analyses identified six well-replicated SNPs with independent effects and significant lung cancer associations (P < 5.0 × 10(-8)) located in TP63 (rs4488809 at 3q28, P = 7.2 × 10(-26)), TERT-CLPTM1L (rs465498 and rs2736100 at 5p15.33, P = 1.2 × 10(-20) and P = 1.0 × 10(-27), respectively), MIPEP-TNFRSF19 (rs753955 at 13q12.12, P = 1.5 × 10(-12)) and MTMR3-HORMAD2-LIF (rs17728461 and rs36600 at 22q12.2, P = 1.1 × 10(-11) and P = 6.2 × 10(-13), respectively). Two of these loci (13q12.12 and 22q12.2) were newly identified in the Chinese population. These results suggest that genetic variants in 3q28, 5p15.33, 13q12.12 and 22q12.2 may contribute to the susceptibility of lung cancer in Han Chinese.     

Exome sequencing identifies somatic mutations of DNA methyltransferase gene DNMT3A in acute monocytic leukemia

Abnormal epigenetic regulation has been implicated in oncogenesis. We report here the identification of somatic mutations by exome sequencing in acute monocytic leukemia, the M5 subtype of acute myeloid leukemia (AML-M5). We discovered mutations in DNMT3A (encoding DNA methyltransferase 3A) in 23 of 112 (20.5%) cases. The DNMT3A mutants showed reduced enzymatic activity or aberrant affinity to histone H3 in vitro. Notably, there were alterations of DNA methylation patterns and/or gene expression profiles (such as HOXB genes) in samples with DNMT3A mutations as compared with those without such changes. Leukemias with DNMT3A mutations constituted a group of poor prognosis with elderly disease onset and of promonocytic as well as monocytic predominance among AML-M5 individuals. Screening other leukemia subtypes showed Arg882 alterations in 13.6% of acute myelomonocytic leukemia (AML-M4) cases. Our work suggests a contribution of aberrant DNA methyltransferase activity to the pathogenesis of acute monocytic leukemia and provides a useful new biomarker for relevant cases.     

A genome-wide association study identifies two new risk loci for Graves' disease

Graves' disease is a common autoimmune disorder characterized by thyroid stimulating hormone receptor autoantibodies (TRAb) and hyperthyroidism. To investigate the genetic architecture of Graves' disease, we conducted a genome-wide association study in 1,536 individuals with Graves' disease (cases) and 1,516 controls. We further evaluated a group of associated SNPs in a second set of 3,994 cases and 3,510 controls. We confirmed four previously reported loci (in the major histocompatibility complex, TSHR, CTLA4 and FCRL3) and identified two new susceptibility loci (the RNASET2-FGFR1OP-CCR6 region at 6q27 (P(combined) = 6.85 × 10(-10) for rs9355610) and an intergenic region at 4p14 (P(combined) = 1.08 × 10(-13) for rs6832151)). These newly associated SNPs were correlated with the expression levels of RNASET2 at 6q27, of CHRNA9 and of a previously uncharacterized gene at 4p14, respectively. Moreover, we identified strong associations of TSHR and major histocompatibility complex class II variants with persistently TRAb-positive Graves' disease.     

The genome of the mesopolyploid crop species Brassica rapa

We report the annotation and analysis of the draft genome sequence of Brassica rapa accession Chiifu-401-42, a Chinese cabbage. We modeled 41,174 protein coding genes in the B. rapa genome, which has undergone genome triplication. We used Arabidopsis thaliana as an outgroup for investigating the consequences of genome triplication, such as structural and functional evolution. The extent of gene loss (fractionation) among triplicated genome segments varies, with one of the three copies consistently retaining a disproportionately large fraction of the genes expected to have been present in its ancestor. Variation in the number of members of gene families present in the genome may contribute to the remarkable morphological plasticity of Brassica species. The B. rapa genome sequence provides an important resource for studying the evolution of polyploid genomes and underpins the genetic improvement of Brassica oil and vegetable crops.