加权序数偏好下多属性群决策的TOPSIS法

对考虑每个属性下各决策者权重的决策问题,提出序数偏好下的群体理想解概念,用TOPSIS法求解.先对决策者加权,用TOPSIS法将每个属性下各备选方案的个体偏好序集结为群体排序;再对属性加权,用TOPSIS法将每个属性下的群体排序综合为备选方案的最终排序结果.以供应商选择算例说明方法的可用性,与现有方法的求解结果比较表明了方法的合理性;该方法将TOPSIS法扩展到处理具有序数偏好的多属性群决策问题,避免了逆序的产生.     

支持企业业务协同的综合设备管理系统研究

为满足制造业信息化的需求,提出了一种面向制造企业各层面的综合设备管理系统.通过分析ERP及MES对设备信息的需求,充分研究设备信息与其他信息系统的协同管理机制,构建设备管理系统与其他系统的信息集成模型及系统的主要功能结构.同时从生产计划与调度出发,利用复杂性理论及调度依附度,研究了设备信息与计划调度间有效协同的原理与方法.最后设计了系统软件构架,围绕设备管理系统,建立了企业生产管理综合信息平台.     

Water as dual functional cocatalyst: A theoretical study on the mechanism of direct aldol reaction on water catalyzed by a leucine derivative

The role of water and stereoselectivity in the direct syn-aldol reaction involving 3-pentanone and 4-nitrobenzaldehyde catalyzed by amino acid derivatives on water has been investigated by density functional theory. Calculations indicate that the formation of intermediate enamine is the rate determining step via a three-step process with activation enthalpies of 50 kcal/mol in the gas phase and 21 kcal/mol in the presence of water. The subsequent nucleophilic addition of enamine to aldehyde is relatively easier with activation enthalpies below 10 kcal/mol both in the gas phase and in the presence of water. The diastereoselective formation of syn- and anti-aldol products results from the preferential formation of Z-enamine to E-enamine, kinetically and thermodynamically. The enantioselectivity of both syn- and anti-products is controlled by the steric repulsive interactions between the amino alcohol moiety of catalyst and the phenyl ring of aldehyde. Calculations show that water molecule can act as a proton shuttle in the proton-transport catalytic processes. The water-assisted proton-transfer is very efficient to reduce the activation barriers via protonation and deprotonation in the formation of C–N and C–C bonds, dehydration, and β-elimination processes by inhibiting the generation of zwitterionic transition states. The theoretical discoveries indicate that in the present proton-transport assistance, the amino alcohol moiety of the catalyst plays a critical role as hydrogen bond donor to anchor substrates with carbonyl group close to the amine or enamine moiety so that the water molecule can bridge the NH of amine and the oxygen of carbonyl by hydrogen bonding interaction around the reactive site to activate the reactants and promote the reaction effectively.     

视黄酸及干扰素对胃癌细胞系MKN45中p16,p21,c-myc基因表达的影响

目的探讨全反式视黄酸及干扰素两种因子对胃癌MKN45细胞的影响.方法将视黄酸及干扰素同时加入胃癌细胞系MKN45中进行细胞培养,用MTT法测定细胞的生长状况,并通过Northern blot和免疫组化测定p16,p21及c-myc的表达情况.结果干扰素(IFN)协同全反式视黄酸(ATRA)可有效地抑制MKN45细胞生长,癌细胞经联合用药诱导后p16和p21基因的表达水平提高,c-myc基因表达水平下降.视黄酸受体RARα基因在MKN45细胞中呈低水平表达,经ATRA和IFN诱导后表达水平提高.结论 ATRA联合IFN诱导可调节p16和p21基因的表达水平,抑制胃癌MKN45细胞生长,这可能与细胞中RARα基因高水平表达有一定关系.     

Aluminium in Alzheimer’s disease: are we still at a crossroad?

Aluminium, an environmentally abundant non-redox trivalent cation has long been implicated in the pathogenesis of Alzheimers disease (AD). However, the definite mechanism of aluminium toxicity in AD is not known. Evidence suggests that trace metal homeostasis plays a crucial role in the normal functioning of the brain, and any disturbance in it can exacerbate events associated with AD. The present paper reviews the scientific literature linking aluminium with AD. The focus is on aluminium levels in brain, region-specific and subcellular distribution, its relation to neurofibrillary tangles, amyloid beta, and other metals. A detailed mechanism of the role of aluminium in oxidative stress and cell death is highlighted. The importance of complex speciation chemistry of aluminium in relation to biology has been emphasized. The debatable role of aluminium in AD and the cross-talk between aluminium and genetic susceptibility are also discussed. Finally, it is concluded based on extensive literature that the neurotoxic effects of aluminium are beyond any doubt, and aluminium as a factor in AD cannot be discarded. However, whether aluminium is a sole factor in AD and whether it is a factor in all AD cases still needs to be understood.Received 22 July 2004; received after revision 3 September 2004; accepted 16 September 2004     

岩土工程系统失效性的数值计算法

介绍了国际结构安全度联合委员会推荐的用于结构可靠性计算的改进型一次二阶矩法，将其推广到岩土工程系统，并给出算例。     

The antigenicity of sheep follicle-stimulating hormone

Résumé L'hormone folliculaire ovine (FSH) purifiée révèle la présence d'antigènes d'hormone lutéinare (LH) et de ceux du sérum ovin. L'antigène LH fait partie de ces derniers. L'absorption des antigènes d'antisérum de l'FSH avec le sérum ovin, élimine l'antigène qui accompagne ceux de l'hormone folliculaire ovine, de l'hormone lutéinaire et du sérum ovin. Ce fait suggère que le sérum ovin agit comme l'hormone lutéinaire. L'antisérum d'hormone lutéinaire est capable d'éliminer l'antigène d'hormone lutéinaire et les antigènes d'hormone folliculaire ovine. Cela signifie que l'un des andigènes du sérum ovin qui est présent aussi dans l'hormone folliculaire ovine, provient de l'hormone lutéinaire. Nos études en cours tendent à vérifier ce fait.     

Maltase activity in human semen

Résumé Nous avons étudié l'activité de la maltase dans la semence humaine en utilisant la technique de la chromatographie sur papier. L'activité de la maltase est exprimée en mg de glucose liberé du substrat de maltose. L'activité de la maltase est spécialement associée avec le plasma séminal. Elle est maximale au pH 5.0. Nous avons aussi étudié les activités de la maltase dans des plasma séminaux des êtres humains, des bufs, des coqs et des lapins. Nous avons trouvé que l'activité de la maltase est la plus haute chez l'homme. En comparaison avec les autres substrats de sucre, l'activité du plasma séminal se montre plus haute dans la maltose.     

The effect of electrical stimulation of olfactory tract on the nucleus preopticus in the catfishHeteropneustes fossilis (Bloch)

Résumé Chez leHeteropneustes fossilis normal le périkaryon des neurons du noyau préoptique montrent une grande accumulation de substance neurosécrétaire AF-positive. Stimulation électrique du nerf olfacteur pendant une minute menait à une dégranulation incomplète, tandis qu'un traitement de dux minutes produisait un épuisement presque complet de la substance neurosécrétoire. Les neurons de la portion magnocellulaire du noyau préoptique paraissent répondre plus rapidement que ceux de la portion parvocellulaire.     

Remote intelligent identification system of structural damage

The focus of this paper is to build the damage identify system, which performs “system identification“ to detcct the positions and extents of structural damages. The identification of structural damage can be characterized as a nonlinear process which linear prediction models such as linear regression are not suitable. However. neural network techniques may provide an effective tool for system identification. The method of damage identification using the radial basis function neural network (P, BFNN) is presented in this paper. Using this method, a simple reinforced concrete structure has been tested both in the absence and presence of noise. The resuits show that the RBFNN identification technology can he used with related success for the solution of dynamic damage identification problems, even in the presence of a noisy identify data. Furthermore, a remote identification system based on that is set up with Java Technologies.